Billy Eppler worked in the Colorado Rockies scouting department from 2000-2004, signing Ryan Spilborghs. He moved to the New York Yankees in November 2004 as Assistant Director of Baseball Operations. He was the Yankees' Director of Professional Scouting from 2006-2009 and Senior Director of Professional Personnel from 2010-2011 before becoming an assistant GM under Brian Cashman.
On October 4, 2015, Eppler was named General Manager of the Los Angeles Angels of Anaheim, replacing Bill Stoneman who had occupied the position on an interim basis since July. He had been a finalist for the same job in 2011, when the Angels had instead hired Jerry Dipoto. He was joining an organization with high expectations, after the team had missed the postseason by a single game in spite of owner Arte Moreno's profligate spending. He also knew he had little margin of maneuver concerning manager Mike Scioscia, whose return for a 17th season in 2016 had just been confirmed: Dipoto's early departure came about because he had lost a power struggle with the long-time manager. Having worked for the Yankees all those, years, he explained that he was used to pressure and high expectations.
Eppler was particularly active in the off-season following the 2017 season. He signed the most-prized free agent of the off-season, Japanese P/DH Shohei Ohtani, then followed that by orchestrating a trade to acquire 2B Ian Kinsler and signed Zack Cozart to play third base, all in an eight-day span.
|Los Angeles Angels General Manager
Source: 2012 Yankees Media Guide
- Alden Gonzalez: "Eppler 'committed to championship standards': Angels' new GM says he believes in working with current personnel", mlb.com, October 5, 2015. 
- Phil Rogers: "Angels' stacked lineup a credit to Eppler's skill: Halos' GM fortifies roster by landing Ohtani, Kinsler and Cozart in 8-day span", mlb.com, December 15, 2017.