| Postseason: |
Won World Series (4-0) over Houston Astros Won AL Championship Series (4-1) over Los Angeles Angels of Anaheim Won AL Division Series (3-0) over Boston Red Sox |

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| Season Summary | 99-63, Final Rank:1, GB: 0.0 | |
| Days in First | 161 | last on Sunday, Oct 2, counts only the days a team played and was in first at the end of the day |
| 183 | last on Oct 2, counts all days of the season including off days | |
| Biggest Lead | 15 | last on Monday, Aug 1, for days on which they played |
| Farthest Behind | never behind | |
| Most Games over .500 | 36 | last on Sunday, Oct 2 |
| Most Games under .500 | never | |
| Longest Winning Streak | 8 | Monday, Apr 18 to Monday, Apr 25, Saturday, Apr 30 to Sunday, May 8 and Wednesday, Jun 15 to Friday, Jun 24 |
| Longest Losing Streak | 7 | Friday, Aug 12 to Saturday, Aug 20 |
| Most Runs Allowed | 12 | Sunday, May 29 |
| Most Runs Scored | 15 | Wednesday, Jun 8 |
| Longest Game (innings) | 16 | Tuesday, Aug 16 |
| Times Shutout by Opponent | 7 | |
| Times Opponent Shutout | 10 | |
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| Rk | Gm# | Date | Tm | Opp | R | RA | Inn | W-L | Rank | GB | Win | Loss | Save | Time | Attendance | Streak | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 | Monday, Apr 4 | boxscore | CHW | CLE | W | 1 | 0 | 1-0 | 1 | Tied | Buehrle | Westbrook | Takatsu | 1:51 | 38,141 | + | ||
| 2 | 2 | Wednesday, Apr 6 | boxscore | CHW | CLE | W | 4 | 3 | 2-0 | 1 | up 0.5 | Marte | Wickman | 2:55 | 10,520 | ++ | |||
| 3 | 3 | Thursday, Apr 7 | boxscore | CHW | CLE | L | 5 | 11 | 11 | 2-1 | 1 | Tied | Rhodes | Vizcaino | 3:56 | 10,800 | - | ||
| 4 | 4 | Friday, Apr 8 | boxscore | CHW | @ | MIN | W | 5 | 1 | 3-1 | 1 | up 1.0 | Hernandez | Lohse | 2:46 | 48,764 | + | ||
| 5 | 5 | Saturday, Apr 9 | boxscore | CHW | @ | MIN | W | 8 | 5 | 4-1 | 1 | up 1.0 | Garland | Radke | Takatsu | 2:37 | 41,533 | ++ | |
| 6 | 6 | Sunday, Apr 10 | boxscore | CHW | @ | MIN | L | 2 | 5 | 4-2 | 1 | up 1.0 | Santana | Buehrle | Nathan | 2:29 | 28,089 | - | |
| 7 | 7 | Monday, Apr 11 | boxscore | CHW | @ | CLE | W | 2 | 1 | 5-2 | 1 | up 1.5 | Garcia | Millwood | Takatsu | 2:39 | 42,461 | + | |
| 8 | 8 | Wednesday, Apr 13 | boxscore | CHW | @ | CLE | W | 5 | 4 | 10 | 6-2 | 1 | up 1.0 | Vizcaino | Howry | Hermanson | 2:54 | 14,410 | ++ |
| 9 | 9 | Thursday, Apr 14 | boxscore | CHW | @ | CLE | L | 6 | 8 | 6-3 | 1 | Tied | Betancourt | Hernandez | Wickman | 3:25 | 12,470 | - | |
| 10 | 10 | Friday, Apr 15 | boxscore | CHW | SEA | W | 6 | 4 | 7-3 | 1 | Tied | Garland | Pineiro | Hermanson | 2:39 | 16,749 | + | ||
| 11 | 11 | Saturday, Apr 16 | boxscore | CHW | SEA | W | 2 | 1 | 8-3 | 1 | Tied | Buehrle | Franklin | 1:39 | 25,931 | ++ | |||
| 12 | 12 | Sunday, Apr 17 | boxscore | CHW | SEA | L | 4 | 5 | 8-4 | 1 | Tied | Meche | Garcia | Guardado | 2:52 | 23,324 | - | ||
| 13 | 13 | Monday, Apr 18 | boxscore | CHW | MIN | W | 5 | 4 | 9-4 | 1 | up 1.0 | Vizcaino | Lohse | Takatsu | 2:47 | 27,018 | + | ||
| 14 | 14 | Tuesday, Apr 19 | boxscore | CHW | MIN | W | 3 | 1 | 10-4 | 1 | up 2.0 | Hernandez | Radke | Marte | 2:40 | 18,310 | ++ | ||
| 15 | 15 | Wednesday, Apr 20 | boxscore | CHW | @ | DET | W | 9 | 1 | 11-4 | 1 | up 2.0 | Garland | Ledezma | 2:19 | 16,887 | +++ | ||
| 16 | 16 | Thursday, Apr 21 | boxscore | CHW | @ | DET | W | 4 | 3 | 12-4 | 1 | up 2.0 | Buehrle | Bonderman | Takatsu | 2:21 | 19,334 | ++++ | |
| 17 | 17 | Friday, Apr 22 | boxscore | CHW | @ | KCR | W | 8 | 2 | 13-4 | 1 | up 3.0 | Garcia | Hernandez | 2:36 | 15,832 | +++++ | ||
| 18 | 18 | Saturday, Apr 23 | boxscore | CHW | @ | KCR | W | 3 | 2 | 10 | 14-4 | 1 | up 3.5 | Marte | MacDougal | 3:24 | 19,641 | ++++++ | |
| 19 | 19 | Sunday, Apr 24 | boxscore | CHW | @ | KCR | W | 4 | 3 | 15-4 | 1 | up 4.0 | Cotts | Camp | Takatsu | 2:57 | 15,331 | +++++++ | |
| 20 | 20 | Monday, Apr 25 | boxscore | CHW | @ | OAK | W | 6 | 0 | 16-4 | 1 | up 5.0 | Garland | Zito | 2:20 | 10,206 | ++++++++ | ||
| 21 | 21 | Tuesday, Apr 26 | boxscore | CHW | @ | OAK | L | 7 | 9 | 16-5 | 1 | up 4.0 | Duchscherer | Marte | Dotel | 3:06 | 20,412 | - | |
| 22 | 22 | Wednesday, Apr 27 | boxscore | CHW | @ | OAK | L | 1 | 2 | 16-6 | 1 | up 3.0 | Duchscherer | Marte | 2:42 | 14,172 | -- | ||
| 23 | 23 | Friday, Apr 29 | boxscore | CHW | DET | L | 2 | 3 | 11 | 16-7 | 1 | up 1.5 | Walker | Takatsu | German | 4:10 | 18,313 | --- | |
| 24 | 24 | Saturday, Apr 30 | boxscore | CHW | DET | W | 4 | 3 | 17-7 | 1 | up 1.5 | Hernandez | Johnson | Hermanson | 2:50 | 30,189 | + | ||
| 25 | 25 | Sunday, May 1 | boxscore | CHW | DET | W | 8 | 0 | 18-7 | 1 | up 2.5 | Garland | Ledezma | 2:23 | 20,862 | ++ | |||
| 26 | 26 | Tuesday, May 3 | boxscore | CHW | KCR | W | 5 | 4 | 19-7 | 1 | up 3.5 | Buehrle | Sisco | Takatsu | 2:13 | 12,362 | +++ | ||
| 27 | 27 | Wednesday, May 4 | boxscore | CHW | KCR | W | 4 | 2 | 20-7 | 1 | up 4.5 | Garcia | Hernandez | Hermanson | 2:39 | 12,712 | ++++ | ||
| 28 | 28 | Thursday, May 5 | boxscore | CHW | KCR | W | 2 | 1 | 21-7 | 1 | up 4.5 | Contreras | Greinke | Takatsu | 2:10 | 15,389 | +++++ | ||
| 29 | 29 | Friday, May 6 | boxscore | CHW | @ | TOR | W | 5 | 3 | 22-7 | 1 | up 4.5 | Hernandez | Frasor | Hermanson | 3:03 | 21,769 | ++++++ | |
| 30 | 30 | Saturday, May 7 | boxscore | CHW | @ | TOR | W | 10 | 7 | 23-7 | 1 | up 4.5 | Garland | Lilly | 2:51 | 23,078 | +++++++ | ||
| 31 | 31 | Sunday, May 8 | boxscore | CHW | @ | TOR | W | 5 | 4 | 24-7 | 1 | up 4.5 | Buehrle | Chacin | Marte | 2:38 | 20,946 | ++++++++ | |
| 32 | 32 | Monday, May 9 | boxscore | CHW | @ | TBD | L | 2 | 4 | 24-8 | 1 | up 4.5 | Carter | Garcia | Baez | 2:45 | 8,774 | - | |
| 33 | 33 | Tuesday, May 10 | boxscore | CHW | @ | TBD | L | 6 | 7 | 24-9 | 1 | up 3.5 | Colome | Takatsu | 3:17 | 9,389 | -- | ||
| 34 | 34 | Wednesday, May 11 | boxscore | CHW | @ | TBD | W | 5 | 2 | 25-9 | 1 | up 4.5 | Hernandez | Brazelton | Hermanson | 2:51 | 9,414 | + | |
| 35 | 35 | Thursday, May 12 | boxscore | CHW | BAL | W | 3 | 2 | 26-9 | 1 | up 5.0 | Garland | Chen | Hermanson | 2:21 | 29,031 | ++ | ||
| 36 | 36 | Friday, May 13 | boxscore | CHW | BAL | W | 5 | 3 | 27-9 | 1 | up 6.0 | Buehrle | Williams | Hermanson | 2:29 | 28,188 | +++ | ||
| 37 | 37 | Saturday, May 14 | boxscore | CHW | BAL | L | 6 | 9 | 27-10 | 1 | up 6.0 | Cabrera | Garcia | Ryan | 3:14 | 37,311 | - | ||
| 38 | 38 | Sunday, May 15 | boxscore | CHW | BAL | L | 2 | 6 | 27-11 | 1 | up 5.0 | Bedard | Contreras | 3:00 | 34,030 | -- | |||
| 39 | 39 | Monday, May 16 | boxscore | CHW | TEX | L | 6 | 7 | 27-12 | 1 | up 4.5 | Regilio | Marte | Cordero | 3:01 | 26,889 | --- | ||
| 40 | 40 | Tuesday, May 17 | boxscore | CHW | TEX | W | 5 | 2 | 28-12 | 1 | up 5.5 | Garland | Astacio | Hermanson | 2:22 | 18,333 | + | ||
| 41 | 41 | Wednesday, May 18 | boxscore | CHW | TEX | W | 7 | 0 | 29-12 | 1 | up 5.5 | Buehrle | Drese | 2:24 | 16,255 | ++ | |||
| 42 | 42 | Friday, May 20 | boxscore | CHW | @ | CHC | W | 5 | 1 | 30-12 | 1 | up 5.0 | Garcia | Maddux | 2:28 | 38,988 | +++ | ||
| 43 | 43 | Saturday, May 21 | boxscore | CHW | @ | CHC | W | 5 | 3 | 31-12 | 1 | up 6.0 | Contreras | Wuertz | Hermanson | 3:09 | 39,461 | ++++ | |
| 44 | 44 | Sunday, May 22 | boxscore | CHW | @ | CHC | L | 3 | 4 | 31-13 | 1 | up 5.0 | Prior | Vizcaino | 2:16 | 39,334 | - | ||
| 45 | 45 | Monday, May 23 | boxscore | CHW | @ | LAA | L | 0 | 4 | 31-14 | 1 | up 5.0 | Santana | Garland | 2:18 | 40,991 | -- | ||
| 46 | 46 | Tuesday, May 24 | boxscore | CHW | @ | LAA | W | 2 | 1 | 11 | 32-14 | 1 | up 5.0 | Marte | Yan | 2:50 | 35,182 | + | |
| 47 | 47 | Wednesday, May 25 | boxscore | CHW | @ | LAA | W | 4 | 2 | 33-14 | 1 | up 6.0 | Garcia | Washburn | Hermanson | 2:30 | 42,716 | ++ | |
| 48 | 48 | Thursday, May 26 | boxscore | CHW | @ | LAA | L | 2 | 3 | 33-15 | 1 | up 5.0 | Lackey | Contreras | Shields | 2:29 | 39,128 | - | |
| 49 | 49 | Friday, May 27 | boxscore | CHW | @ | TEX | L | 2 | 6 | 33-16 | 1 | up 4.0 | Young | McCarthy | Cordero | 2:30 | 31,149 | -- | |
| 50 | 50 | Sunday, May 29 | boxscore | CHW | @ | TEX | L | 4 | 12 | 33-17 | 1 | up 3.5 | Park | Garland | 2:53 | 36,265 | --- | ||
| Rk | Gm# | Date | Tm | Opp | R | RA | Inn | W-L | Rank | GB | Win | Loss | Save | Time | Attendance | Streak | |||
| 51 | 51 | Monday, May 30 | boxscore | CHW | LAA | W | 5 | 4 | 34-17 | 1 | up 4.0 | Politte | Shields | 2:49 | 38,685 | + | |||
| 52 | 52 | Tuesday, May 31 | boxscore | CHW | LAA | W | 5 | 4 | 35-17 | 1 | up 5.0 | Politte | Donnelly | 2:40 | 19,864 | ++ | |||
| 53 | 53 | Wednesday, Jun 1 | boxscore | CHW | LAA | L | 7 | 10 | 35-18 | 1 | up 4.0 | Byrd | Walker | 3:15 | 19,393 | - | |||
| 54 | 54 | Friday, Jun 3 | boxscore | CHW | CLE | W | 6 | 4 | 36-18 | 1 | up 3.5 | Hernandez | Westbrook | Hermanson | 2:27 | 23,132 | + | ||
| 55 | 55 | Saturday, Jun 4 | boxscore | CHW | CLE | W | 6 | 5 | 37-18 | 1 | up 4.5 | Garland | Davis | Hermanson | 2:53 | 26,365 | ++ | ||
| 56 | 56 | Sunday, Jun 5 | boxscore | CHW | CLE | L | 4 | 6 | 12 | 37-19 | 1 | up 3.5 | Riske | Hermanson | 4:11 | 26,146 | - | ||
| 57 | 57 | Monday, Jun 6 | boxscore | CHW | @ | COL | W | 9 | 3 | 38-19 | 1 | up 4.0 | Garcia | Kennedy | 2:31 | 25,030 | + | ||
| 58 | 58 | Tuesday, Jun 7 | boxscore | CHW | @ | COL | W | 2 | 1 | 39-19 | 1 | up 4.0 | Contreras | Kim | Hermanson | 2:37 | 21,576 | ++ | |
| 59 | 59 | Wednesday, Jun 8 | boxscore | CHW | @ | COL | W | 15 | 5 | 40-19 | 1 | up 4.0 | Hernandez | Francis | 3:26 | 23,268 | +++ | ||
| 60 | 60 | Friday, Jun 10 | boxscore | CHW | @ | SDP | W | 4 | 2 | 41-19 | 1 | up 5.5 | Garland | Williams | Hermanson | 2:19 | 38,126 | ++++ | |
| 61 | 61 | Saturday, Jun 11 | boxscore | CHW | @ | SDP | L | 1 | 2 | 41-20 | 1 | up 4.5 | Linebrink | Hermanson | 2:23 | 41,020 | - | ||
| 62 | 62 | Sunday, Jun 12 | boxscore | CHW | @ | SDP | W | 8 | 5 | 10 | 42-20 | 1 | up 5.5 | Politte | Hoffman | 3:22 | 38,306 | + | |
| 63 | 63 | Monday, Jun 13 | boxscore | CHW | ARI | L | 1 | 8 | 42-21 | 1 | up 5.0 | Estes | Contreras | 2:33 | 32,952 | - | |||
| 64 | 64 | Tuesday, Jun 14 | boxscore | CHW | ARI | L | 4 | 10 | 42-22 | 1 | up 4.0 | Vazquez | Hernandez | 2:49 | 24,831 | -- | |||
| 65 | 65 | Wednesday, Jun 15 | boxscore | CHW | ARI | W | 12 | 6 | 43-22 | 1 | up 5.0 | Garland | Ortiz | 2:43 | 24,499 | + | |||
| 66 | 66 | Friday, Jun 17 | boxscore | CHW | LAD | W | 6 | 0 | 44-22 | 1 | up 5.5 | Buehrle | Houlton | 2:24 | 28,870 | ++ | |||
| 67 | 67 | Saturday, Jun 18 | boxscore | CHW | LAD | W | 5 | 3 | 45-22 | 1 | up 6.5 | Politte | Brazoban | 2:34 | 36,067 | +++ | |||
| 68 | 68 | Sunday, Jun 19 | boxscore | CHW | LAD | W | 4 | 3 | 46-22 | 1 | up 7.5 | Politte | Sanchez | Hermanson | 2:48 | 27,350 | ++++ | ||
| 69 | 69 | Monday, Jun 20 | boxscore | CHW | KCR | W | 11 | 8 | 47-22 | 1 | up 8.0 | Cotts | Jensen | Hermanson | 3:16 | 34,345 | +++++ | ||
| 70 | 70 | Tuesday, Jun 21 | boxscore | CHW | KCR | W | 5 | 1 | 48-22 | 1 | up 9.0 | Garland | Greinke | 2:23 | 28,206 | ++++++ | |||
| 71 | 71 | Wednesday, Jun 22 | boxscore | CHW | KCR | W | 5 | 1 | 49-22 | 1 | up10.0 | Buehrle | Howell | 2:04 | 24,544 | +++++++ | |||
| 72 | 72 | Friday, Jun 24 | boxscore | CHW | CHC | W | 12 | 2 | 50-22 | 1 | up10.5 | Garcia | Mitre | 2:42 | 39,610 | ++++++++ | |||
| 73 | 73 | Saturday, Jun 25 | boxscore | CHW | CHC | L | 2 | 6 | 50-23 | 1 | up10.5 | Maddux | Contreras | 2:51 | 39,241 | - | |||
| 74 | 74 | Sunday, Jun 26 | boxscore | CHW | CHC | L | 0 | 2 | 50-24 | 1 | up 9.5 | Prior | Garland | Dempster | 2:14 | 39,143 | -- | ||
| 75 | 75 | Tuesday, Jun 28 | boxscore | CHW | @ | DET | W | 2 | 1 | 51-24 | 1 | up 9.0 | Buehrle | Robertson | Hermanson | 2:29 | 23,602 | + | |
| 76 | 76 | Wednesday, Jun 29 | boxscore | CHW | @ | DET | W | 4 | 3 | 13 | 52-24 | 1 | up10.0 | Takatsu | Rodney | 3:59 | 19,931 | ++ | |
| 77 | 77 | Thursday, Jun 30 | boxscore | CHW | @ | DET | W | 6 | 1 | 53-24 | 1 | up10.5 | Garcia | Maroth | 23,447 | +++ | |||
| 78 | 78 | Friday, Jul 1 | boxscore | CHW | @ | OAK | L | 2 | 6 | 53-25 | 1 | up 9.5 | Harden | Contreras | 3:08 | 15,293 | - | ||
| 79 | 79 | Saturday, Jul 2 | boxscore | CHW | @ | OAK | W | 5 | 3 | 54-25 | 1 | up 9.5 | Garland | Saarloos | Hermanson | 2:13 | 45,712 | + | |
| 80 | 80 | Sunday, Jul 3 | boxscore | CHW | @ | OAK | L | 2 | 7 | 54-26 | 1 | up 8.5 | Zito | Buehrle | 2:20 | 22,596 | - | ||
| 81 | 81 | Monday, Jul 4 | boxscore | CHW | TBD | W | 10 | 8 | 55-26 | 1 | up 8.5 | Vizcaino | Nomo | Hermanson | 3:11 | 37,351 | + | ||
| 82 | 82 | Tuesday, Jul 5 | boxscore | CHW | TBD | W | 6 | 4 | 56-26 | 1 | up 9.5 | Politte | Carter | Hermanson | 2:29 | 21,555 | ++ | ||
| 83 | 83 | Wednesday, Jul 6 | boxscore | CHW | TBD | W | 7 | 2 | 57-26 | 1 | up10.5 | Contreras | Fossum | 2:37 | 24,773 | +++ | |||
| 84 | 84 | Friday, Jul 8 | boxscore | CHW | OAK | L | 2 | 4 | 57-27 | 1 | up10.0 | Saarloos | Garland | Street | 2:55 | 33,623 | - | ||
| 85 | 85 | Saturday, Jul 9 | boxscore | CHW | OAK | L | 1 | 10 | 57-28 | 1 | up10.0 | Zito | Buehrle | 2:39 | 38,318 | -- | |||
| 86 | 86 | Sunday, Jul 10 | boxscore | CHW | OAK | L | 8 | 9 | 11 | 57-29 | 1 | up 9.0 | Street | Vizcaino | 3:47 | 33,221 | --- | ||
| 87 | 87 | Thursday, Jul 14 | boxscore | CHW | @ | CLE | W | 1 | 0 | 58-29 | 1 | up10.0 | Contreras | Millwood | Hermanson | 2:56 | 21,472 | + | |
| 88 | 88 | Friday, Jul 15 | boxscore | CHW | @ | CLE | W | 7 | 1 | 59-29 | 1 | up11.0 | Garcia | Sabathia | 3:01 | 29,684 | ++ | ||
| 89 | 89 | Saturday, Jul 16 | boxscore | CHW | @ | CLE | W | 7 | 5 | 60-29 | 1 | up11.0 | Buehrle | Westbrook | Marte | 2:46 | 27,114 | +++ | |
| 90 | 90 | Sunday, Jul 17 | boxscore | CHW | @ | CLE | W | 4 | 0 | 61-29 | 1 | up12.0 | Garland | Elarton | 2:42 | 24,548 | ++++ | ||
| 91 | 91 | Monday, Jul 18 | boxscore | CHW | DET | W | 7 | 5 | 62-29 | 1 | up13.0 | Vizcaino | Spurling | Politte | 2:52 | 37,556 | +++++ | ||
| 92 | 92 | Tuesday, Jul 19 | boxscore | CHW | DET | L | 1 | 7 | 62-30 | 1 | up12.0 | Bonderman | Contreras | 2:35 | 31,008 | - | |||
| 93 | 93 | Wednesday, Jul 20 | boxscore | CHW | DET | L | 6 | 8 | 62-31 | 1 | up11.0 | Robertson | Garcia | Dingman | 39,146 | -- | |||
| 94 | 94 | Thursday, Jul 21 | boxscore | CHW | BOS | L | 5 | 6 | 62-32 | 1 | up10.0 | Schilling | Vizcaino | 3:17 | 36,784 | --- | |||
| 95 | 95 | Friday, Jul 22 | boxscore | CHW | BOS | W | 8 | 4 | 63-32 | 1 | up11.0 | Garland | Wakefield | 2:49 | 37,511 | + | |||
| 96 | 96 | Saturday, Jul 23 | boxscore | CHW | BOS | L | 0 | 3 | 63-33 | 1 | up10.5 | Miller | Hernandez | Schilling | 2:39 | 39,408 | - | ||
| 97 | 97 | Sunday, Jul 24 | boxscore | CHW | BOS | W | 6 | 4 | 64-33 | 1 | up11.5 | Contreras | Arroyo | Hermanson | 3:16 | 37,168 | + | ||
| 98 | 98 | Monday, Jul 25 | boxscore | CHW | @ | KCR | W | 14 | 6 | 65-33 | 1 | up12.0 | Garcia | Greinke | 3:28 | 15,515 | ++ | ||
| 99 | 99 | Tuesday, Jul 26 | boxscore | CHW | @ | KCR | L | 1 | 7 | 65-34 | 1 | up12.0 | Lima | Buehrle | 2:24 | 19,175 | - | ||
| 100 | 100 | Wednesday, Jul 27 | boxscore | CHW | @ | KCR | L | 5 | 6 | 13 | 65-35 | 1 | up11.0 | Camp | Vizcaino | 4:25 | 17,378 | -- | |
| Rk | Gm# | Date | Tm | Opp | R | RA | Inn | W-L | Rank | GB | Win | Loss | Save | Time | Attendance | Streak | |||
| 101 | 101 | Friday, Jul 29 | boxscore | CHW | @ | BAL | W | 7 | 2 | 66-35 | 1 | up12.5 | Hernandez | Bedard | 3:25 | 45,267 | + | ||
| 102 | 102 | Saturday, Jul 30 | boxscore | CHW | @ | BAL | W | 9 | 6 | 67-35 | 1 | up13.5 | Cotts | Ray | Hermanson | 3:15 | 40,100 | ++ | |
| 103 | 103 | Sunday, Jul 31 | boxscore | CHW | @ | BAL | W | 9 | 4 | 68-35 | 1 | up14.5 | Garcia | Lopez | 3:27 | 31,982 | +++ | ||
| 104 | 104 | Monday, Aug 1 | boxscore | CHW | @ | BAL | W | 6 | 3 | 69-35 | 1 | up15.0 | Buehrle | Cabrera | Hermanson | 3:09 | 47,823 | ++++ | |
| 105 | 105 | Tuesday, Aug 2 | boxscore | CHW | TOR | L | 3 | 7 | 69-36 | 1 | up14.0 | Towers | Garland | 2:28 | 32,162 | - | |||
| 106 | 106 | Wednesday, Aug 3 | boxscore | CHW | TOR | L | 3 | 4 | 69-37 | 1 | up13.0 | Bush | Hernandez | Batista | 2:52 | 28,116 | -- | ||
| 107 | 107 | Thursday, Aug 4 | boxscore | CHW | TOR | W | 5 | 4 | 70-37 | 1 | up14.0 | Vizcaino | Speier | Hermanson | 3:13 | 32,027 | + | ||
| 108 | 108 | Friday, Aug 5 | boxscore | CHW | SEA | L | 2 | 4 | 70-38 | 1 | up13.0 | Pineiro | Garcia | Guardado | 2:37 | 39,165 | - | ||
| 109 | 109 | Saturday, Aug 6 | boxscore | CHW | SEA | W | 4 | 2 | 71-38 | 1 | up13.0 | Buehrle | Moyer | Hermanson | 2:19 | 37,529 | + | ||
| 110 | 110 | Sunday, Aug 7 | boxscore | CHW | SEA | W | 3 | 1 | 72-38 | 1 | up13.0 | Garland | Harris | Hermanson | 2:29 | 35,706 | ++ | ||
| 111 | 111 | Monday, Aug 8 | boxscore | CHW | @ | NYY | L | 2 | 3 | 72-39 | 1 | up12.5 | Mussina | Hernandez | Rivera | 2:58 | 54,871 | - | |
| 112 | 112 | Tuesday, Aug 9 | boxscore | CHW | @ | NYY | W | 2 | 1 | 73-39 | 1 | up12.5 | Contreras | Chacon | Hermanson | 3:20 | 53,946 | + | |
| 113 | 113 | Wednesday, Aug 10 | boxscore | CHW | @ | NYY | W | 2 | 1 | 10 | 74-39 | 1 | up12.5 | Cotts | Rivera | Hermanson | 2:58 | 54,635 | ++ |
| 114 | 114 | Friday, Aug 12 | boxscore | CHW | @ | BOS | L | 8 | 9 | 74-40 | 1 | up12.0 | Bradford | Buehrle | 2:57 | 35,132 | - | ||
| 115 | 115 | Saturday, Aug 13 | boxscore | CHW | @ | BOS | L | 4 | 7 | 74-41 | 1 | up12.0 | Wakefield | Garland | 2:49 | 35,055 | -- | ||
| 116 | 116 | Monday, Aug 15 | boxscore | CHW | MIN | L | 2 | 4 | 74-42 | 1 | up12.0 | Lohse | Contreras | Nathan | 2:51 | 39,160 | --- | ||
| 117 | 117 | Tuesday, Aug 16 | boxscore | CHW | MIN | L | 4 | 9 | 16 | 74-43 | 1 | up11.0 | Romero | Adkins | 5:09 | 34,533 | ---- | ||
| 118 | 118 | Wednesday, Aug 17 | boxscore | CHW | MIN | L | 1 | 5 | 74-44 | 1 | up11.0 | Santana | Buehrle | 2:34 | 33,158 | ----- | |||
| 119 | 119 | Friday, Aug 19 | boxscore | CHW | NYY | L | 1 | 3 | 74-45 | 1 | up 9.5 | Mussina | Garland | Rivera | 2:55 | 39,496 | ------ | ||
| 120 | 120 | Saturday, Aug 20 | boxscore | CHW | NYY | L | 0 | 5 | 74-46 | 1 | up 8.5 | Chacon | Hernandez | 3:07 | 38,938 | ------- | |||
| 121 | 121 | Sunday, Aug 21 | boxscore | CHW | NYY | W | 6 | 2 | 75-46 | 1 | up 8.5 | Contreras | Johnson | 2:18 | 39,480 | + | |||
| 122 | 122 | Tuesday, Aug 23 | boxscore | CHW | @ | MIN | L | 0 | 1 | 75-47 | 1 | up 7.0 | Santana | Garcia | Nathan | 2:08 | 33,572 | - | |
| 123 | 123 | Wednesday, Aug 24 | boxscore | CHW | @ | MIN | W | 6 | 4 | 76-47 | 1 | up 8.0 | Buehrle | Mays | Hermanson | 2:33 | 32,687 | + | |
| 124 | 124 | Thursday, Aug 25 | boxscore | CHW | @ | MIN | W | 2 | 1 | 10 | 77-47 | 1 | up 8.0 | Hermanson | Crain | Jenks | 2:45 | 26,895 | ++ |
| 125 | 125 | Friday, Aug 26 | boxscore | CHW | @ | SEA | W | 5 | 3 | 12 | 78-47 | 1 | up 8.0 | Vizcaino | Nelson | Hermanson | 3:36 | 40,431 | +++ |
| 126 | 126 | Saturday, Aug 27 | boxscore | CHW | @ | SEA | W | 4 | 3 | 79-47 | 1 | up 9.0 | Contreras | Pineiro | Marte | 2:53 | 37,326 | ++++ | |
| 127 | 127 | Sunday, Aug 28 | boxscore | CHW | @ | SEA | L | 2 | 9 | 79-48 | 1 | up 8.0 | Moyer | Garcia | 2:39 | 36,868 | - | ||
| 128 | 128 | Monday, Aug 29 | boxscore | CHW | @ | TEX | L | 5 | 7 | 79-49 | 1 | up 7.0 | Dominguez | Buehrle | Brocail | 2:24 | 27,819 | -- | |
| 129 | 129 | Tuesday, Aug 30 | boxscore | CHW | @ | TEX | L | 6 | 8 | 79-50 | 1 | up 7.0 | Wilson | Garland | Cordero | 2:39 | 0 | --- | |
| 130 | 130 | Tuesday, Aug 30 | boxscore | CHW | @ | TEX | W | 8 | 0 | 80-50 | 1 | up 7.0 | McCarthy | Volquez | 2:43 | 28,183 | + | ||
| 131 | 131 | Wednesday, Aug 31 | boxscore | CHW | @ | TEX | L | 2 | 9 | 80-51 | 1 | up 7.0 | Loe | Hernandez | 2:42 | 23,493 | - | ||
| 132 | 132 | Thursday, Sep 1 | boxscore | CHW | DET | W | 12 | 3 | 81-51 | 1 | up 7.5 | Contreras | Johnson | 2:32 | 20,743 | + | |||
| 133 | 133 | Friday, Sep 2 | boxscore | CHW | DET | W | 9 | 1 | 82-51 | 1 | up 7.5 | Garcia | Douglass | 2:30 | 25,502 | ++ | |||
| 134 | 134 | Saturday, Sep 3 | boxscore | CHW | DET | W | 6 | 2 | 83-51 | 1 | up 8.5 | Buehrle | Robertson | 2:21 | 30,509 | +++ | |||
| 135 | 135 | Sunday, Sep 4 | boxscore | CHW | DET | W | 2 | 0 | 84-51 | 1 | up 9.5 | Garland | Bonderman | 2:07 | 30,931 | ++++ | |||
| 136 | 136 | Monday, Sep 5 | boxscore | CHW | @ | BOS | W | 5 | 3 | 85-51 | 1 | up 9.5 | McCarthy | Schilling | 3:11 | 35,673 | +++++ | ||
| 137 | 137 | Tuesday, Sep 6 | boxscore | CHW | KCR | W | 6 | 5 | 86-51 | 1 | up 9.5 | Hernandez | Lima | Hermanson | 2:45 | 14,571 | ++++++ | ||
| 138 | 138 | Wednesday, Sep 7 | boxscore | CHW | KCR | W | 1 | 0 | 87-51 | 1 | up 9.5 | Contreras | Wood | Hermanson | 2:37 | 18,513 | +++++++ | ||
| 139 | 139 | Thursday, Sep 8 | boxscore | CHW | KCR | L | 2 | 4 | 87-52 | 1 | up 8.5 | Howell | Garcia | MacDougal | 2:50 | 17,701 | - | ||
| 140 | 140 | Friday, Sep 9 | boxscore | CHW | LAA | L | 5 | 6 | 12 | 87-53 | 1 | up 7.5 | Donnelly | Hermanson | Rodriguez | 3:45 | 28,059 | -- | |
| 141 | 141 | Saturday, Sep 10 | boxscore | CHW | LAA | L | 5 | 10 | 87-54 | 1 | up 6.5 | Colon | Garland | 3:03 | 26,538 | --- | |||
| 142 | 142 | Sunday, Sep 11 | boxscore | CHW | LAA | L | 1 | 6 | 87-55 | 1 | up 5.5 | Lackey | Hernandez | 2:36 | 29,321 | ---- | |||
| 143 | 143 | Tuesday, Sep 13 | boxscore | CHW | @ | KCR | W | 6 | 4 | 88-55 | 1 | up 6.0 | Contreras | Wood | Jenks | 3:01 | 9,535 | + | |
| 144 | 144 | Wednesday, Sep 14 | boxscore | CHW | @ | KCR | L | 9 | 10 | 88-56 | 1 | up 5.0 | Demaria | Hermanson | 3:03 | 9,922 | - | ||
| 145 | 145 | Thursday, Sep 15 | boxscore | CHW | @ | KCR | L | 5 | 7 | 88-57 | 1 | up 4.5 | Burgos | Buehrle | MacDougal | 2:58 | 9,258 | -- | |
| 146 | 146 | Friday, Sep 16 | boxscore | CHW | @ | MIN | W | 2 | 1 | 10 | 89-57 | 1 | up 4.5 | Jenks | Crain | 2:49 | 26,951 | + | |
| 147 | 147 | Saturday, Sep 17 | boxscore | CHW | @ | MIN | L | 0 | 5 | 89-58 | 1 | up 3.5 | Santana | Hernandez | Nathan | 2:50 | 24,866 | - | |
| 148 | 148 | Sunday, Sep 18 | boxscore | CHW | @ | MIN | W | 2 | 1 | 90-58 | 1 | up 3.5 | Contreras | Rincon | Jenks | 2:17 | 23,559 | + | |
| 149 | 149 | Monday, Sep 19 | boxscore | CHW | CLE | L | 5 | 7 | 90-59 | 1 | up 2.5 | Betancourt | Marte | Wickman | 3:31 | 35,748 | - | ||
| 150 | 150 | Tuesday, Sep 20 | boxscore | CHW | CLE | W | 7 | 6 | 10 | 91-59 | 1 | up 3.5 | Hermanson | Riske | 3:31 | 26,147 | + | ||
| Rk | Gm# | Date | Tm | Opp | R | RA | Inn | W-L | Rank | GB | Win | Loss | Save | Time | Attendance | Streak | |||
| 151 | 151 | Wednesday, Sep 21 | boxscore | CHW | CLE | L | 0 | 8 | 91-60 | 1 | up 2.5 | Elarton | Garland | 2:47 | 36,543 | - | |||
| 152 | 152 | Thursday, Sep 22 | boxscore | CHW | MIN | L | 1 | 4 | 11 | 91-61 | 1 | up 1.5 | Crain | Jenks | Nathan | 3:12 | 25,112 | -- | |
| 153 | 153 | Friday, Sep 23 | boxscore | CHW | MIN | W | 3 | 1 | 92-61 | 1 | up 1.5 | Contreras | Lohse | 2:19 | 28,003 | + | |||
| 154 | 154 | Saturday, Sep 24 | boxscore | CHW | MIN | W | 8 | 1 | 93-61 | 1 | up 1.5 | Garcia | Mays | 2:27 | 37,699 | ++ | |||
| 155 | 155 | Sunday, Sep 25 | boxscore | CHW | MIN | W | 4 | 1 | 94-61 | 1 | up 2.5 | Buehrle | Liriano | 1:53 | 30,402 | +++ | |||
| 156 | 156 | Monday, Sep 26 | boxscore | CHW | @ | DET | L | 3 | 4 | 94-62 | 1 | up 2.0 | Rodney | Politte | 2:43 | 10,840 | - | ||
| 157 | 157 | Tuesday, Sep 27 | boxscore | CHW | @ | DET | L | 2 | 3 | 94-63 | 1 | up 2.0 | Robertson | McCarthy | Rodney | 2:21 | 13,983 | -- | |
| 158 | 158 | Wednesday, Sep 28 | boxscore | CHW | @ | DET | W | 8 | 2 | 95-63 | 1 | up 3.0 | Contreras | Douglass | 2:46 | 17,221 | + | ||
| 159 | 159 | Thursday, Sep 29 | boxscore | CHW | @ | DET | W | 4 | 2 | 96-63 | 1 | up 3.0 | Garcia | Grilli | Jenks | 2:22 | 13,494 | ++ | |
| 160 | 160 | Friday, Sep 30 | boxscore | CHW | @ | CLE | W | 3 | 2 | 13 | 97-63 | 1 | up 4.0 | Politte | Cabrera | Jenks | 4:17 | 41,072 | +++ |
| 161 | 161 | Saturday, Oct 1 | boxscore | CHW | @ | CLE | W | 4 | 3 | 98-63 | 1 | up 5.0 | Garland | Westbrook | Jenks | 2:48 | 41,026 | ++++ | |
| 162 | 162 | Sunday, Oct 2 | boxscore | CHW | @ | CLE | W | 3 | 1 | 99-63 | 1 | up 6.0 | McCarthy | Elarton | Hernandez | 2:56 | 41,034 | +++++ | |
| Rk | Gm# | Date | Tm | Opp | R | RA | Inn | W-L | Rank | GB | Win | Loss | Save | Time | Attendance | Streak |
Rank and Games Behind are at the end of all games played on that date.