+ - Indicates Hall of Famer. Bold indicates active player.
Statistic Description: Strikeouts
| Rank | Player (yrs, age) | Strikeouts | Throws |
|---|---|---|---|
| 1. | Jamie Moyer (25, 49) | 2441 | L |
| 2. | Andy Pettitte (17, 40) | 2320 | L |
| 3. | CC Sabathia (12, 31) | 2214 | L |
| 4. | Kevin Millwood (16, 37) | 2083 | R |
| 5. | Roy Halladay (15, 35) | 2066 | R |
| 6. | Johan Santana (12, 33) | 1988 | L |
| 7. | Livan Hernandez (17, 37) | 1976 | R |
| 8. | A.J. Burnett (14, 35) | 1971 | R |
| 9. | Ryan Dempster (15, 35) | 1918 | R |
| 10. | Bartolo Colon (15, 39) | 1833 | R |
| 11. | Roy Oswalt (12, 34) | 1818 | R |
| 12. | Tim Hudson (14, 36) | 1801 | R |
| 13. | Barry Zito (13, 34) | 1797 | L |
| 14. | Randy Wolf (14, 35) | 1767 | L |
| 15. | Josh Beckett (12, 32) | 1753 | R |
| 16. | Jake Peavy (11, 31) | 1748 | R |
| 17. | Derek Lowe (16, 39) | 1714 | R |
| 18. | Chris Carpenter (15, 37) | 1697 | R |
| 19. | Ted Lilly (14, 36) | 1663 | L |
| 20. | Carlos Zambrano (12, 31) | 1637 | R |
| 21. | Dan Haren (10, 31) | 1585 | R |
| 22. | Kerry Wood (14, 35) | 1582 | R |
| 23. | Freddy Garcia (14, 35) | 1575 | R |
| 24. | Cliff Lee (11, 33) | 1530 | L |
| 25. | Mark Buehrle (13, 33) | 1521 | L |
| 26. | Felix Hernandez (8, 26) | 1487 | R |
| 27. | John Lackey (10, 33) | 1465 | R |
| 28. | Aaron Harang (11, 34) | 1460 | R |
| 29. | Justin Verlander (8, 29) | 1454 | R |
| 30. | Jeff Suppan (17, 37) | 1390 | R |
| 31. | Brett Myers (11, 31) | 1367 | R |
| 32. | Bronson Arroyo (13, 35) | 1355 | R |
| 33. | Zack Greinke (9, 28) | 1332 | R |
| 34. | Ben Sheets (10, 33) | 1325 | R |
| 35. | Tim Lincecum (6, 28) | 1317 | R |
| 36. | Cole Hamels (7, 28) | 1307 | L |
| 37. | Doug Davis (13, 36) | 1279 | L |
| 38. | Matt Cain (8, 27) | 1278 | R |
| 39. | Brad Penny (13, 34) | 1260 | R |
| 40. | Miguel Batista (18, 41) | 1250 | R |
| James Shields (7, 30) | 1250 | R | |
| 42. | Kyle Lohse (12, 33) | 1238 | R |
| 43. | Darren Oliver (19, 41) | 1219 | L |
| 44. | Brett Tomko (14, 39) | 1209 | R |
| 45. | Ervin Santana (8, 29) | 1167 | R |
| 46. | Oliver Perez (10, 30) | 1150 | L |
| 47. | Wandy Rodriguez (8, 33) | 1143 | L |
| 48. | Octavio Dotel (14, 38) | 1139 | R |
| 49. | Vicente Padilla (14, 34) | 1121 | R |
| 50. | Mariano Rivera (18, 42) | 1119 | R |
| Rank | Player (yrs, age) | Strikeouts | Throws |
| Jered Weaver (7, 29) | 1119 | R | |
| 52. | Carl Pavano (14, 36) | 1091 | R |
| 53. | Jamey Wright (17, 37) | 1070 | R |
| 54. | Jason Marquis (13, 33) | 1065 | R |
| 55. | Jon Lester (7, 28) | 1060 | L |
| 56. | Joel Pineiro (12, 33) | 1058 | R |
| 57. | Erik Bedard (9, 33) | 1044 | L |
| 58. | Chad Billingsley (7, 27) | 1031 | R |
| 59. | Bruce Chen (14, 35) | 1022 | L |
| 60. | Joe Blanton (9, 31) | 978 | R |
| Ubaldo Jimenez (7, 28) | 978 | R | |
| 62. | Clayton Kershaw (5, 24) | 974 | L |
| 63. | Chris Capuano (8, 33) | 969 | L |
| Edwin Jackson (10, 28) | 969 | R | |
| 65. | Kip Wells (12, 35) | 963 | R |
| 66. | Yovani Gallardo (6, 26) | 936 | R |
| 67. | Jake Westbrook (12, 34) | 921 | R |
| 68. | Kyle Farnsworth (14, 36) | 917 | R |
| 69. | Ricky Nolasco (7, 29) | 911 | R |
| 70. | Adam Wainwright (7, 30) | 908 | R |
| 71. | Dontrelle Willis (9, 30) | 896 | L |
| 72. | Ramon Ortiz (11, 39) | 887 | R |
| 73. | Jose Contreras (10, 40) | 884 | R |
| 74. | Gavin Floyd (9, 29) | 878 | R |
| Francisco Rodriguez (11, 30) | 878 | R | |
| 76. | Matt Garza (7, 28) | 865 | R |
| Rodrigo Lopez (11, 36) | 865 | R | |
| 78. | LaTroy Hawkins (18, 39) | 862 | R |
| 79. | Francisco Liriano (7, 28) | 846 | L |
| 80. | Paul Maholm (8, 30) | 845 | L |
| 81. | Joe Nathan (12, 37) | 839 | R |
| 82. | Josh Johnson (8, 28) | 832 | R |
| 83. | Jason Isringhausen (16, 39) | 830 | R |
| 84. | Max Scherzer (5, 27) | 829 | R |
| 85. | C.J. Wilson (8, 31) | 810 | L |
| 86. | Brad Lidge (11, 35) | 799 | R |
| 87. | Francisco Cordero (14, 37) | 796 | R |
| 88. | Jonathan Sanchez (7, 29) | 781 | L |
| 89. | Nate Robertson (9, 34) | 775 | L |
| 90. | Scott Baker (7, 30) | 770 | R |
| Jeff Francis (8, 31) | 770 | L | |
| 92. | Dave Bush (8, 32) | 767 | R |
| 93. | Joaquin Benoit (11, 34) | 760 | R |
| 94. | Mark Prior (5, 31) | 757 | R |
| 95. | Chris Young (9, 33) | 755 | R |
| 96. | Shaun Marcum (7, 30) | 746 | R |
| 97. | John Danks (6, 27) | 744 | L |
| 98. | R.A. Dickey (10, 37) | 739 | R |
| 99. | Anibal Sanchez (7, 28) | 733 | R |
| 100. | Jeremy Guthrie (9, 33) | 727 | R |