MLB Scores and Standings Tuesday, September 22, 1981
| Detroit Tigers | 6 | Final |
| Baltimore Orioles | 3 |
| W | George Cappuzzello (1-0) |
| L | Sammy Stewart (3-7) |
| Milwaukee Brewers | 10 | Final |
| Boston Red Sox | 8 |
| W | Rollie Fingers (5-3) |
| L | Mark Clear (8-2) |
| Chicago White Sox | 0 | Final |
| California Angels | 1 |
| W | Ángel Moreno (1-1) |
| L | Ross Baumgarten (5-9) |
| S | Don Aase (11) |
| St. Louis Cardinals | 3 | Final |
| Chicago Cubs | 4 |
| W | Randy Martz (5-6) |
| L | Mark Littell (1-3) |
| Atlanta Braves | 0 | Final |
| Houston Astros | 3 |
| W | Don Sutton (10-8) |
| L | Gaylord Perry (7-8) |
| Minnesota Twins | 1 | Final |
| Kansas City Royals | 2 |
| W | Larry Gura (10-6) |
| L | Fernando Arroyo (6-9) |
| Philadelphia Phillies | 2 | Final |
| Montreal Expos | 6 |
| W | Steve Rogers (11-7) |
| L | Dick Ruthven (11-6) |
| Cleveland Indians | 6 | Final |
| New York Yankees | 4 |
| W | Len Barker (8-7) |
| L | Dave Righetti (6-4) |
| S | Sid Monge (4) |
| Pittsburgh Pirates | 5 | Final |
| New York Mets | 3 |
| W | Jim Bibby (6-3) |
| L | Mike Scott (4-10) |
| S | Rod Scurry (6) |
| Cincinnati Reds | 3 | Final |
| San Diego Padres | 2 |
| W | Tom Seaver (13-2) |
| L | Juan Eichelberger (8-7) |
| S | Tom Hume (11) |
| Los Angeles Dodgers | 2 | Final |
| San Francisco Giants | 5 |
| W | Ed Whitson (6-8) |
| L | Fernando Valenzuela (13-5) |
| S | Greg Minton (17) |
| Seattle Mariners | 3 | Final |
| Texas Rangers | 2 |
| W | Ken Clay (1-6) |
| L | John Butcher (0-1) |
| S | Shane Rawley (6) |
| Oakland Athletics | 3 | Final |
| Toronto Blue Jays | 2 | (13) |
| W | Dave Beard (1-1) |
| L | Luis Leal (7-11) |
| Oakland Athletics | 4 | Final |
| Toronto Blue Jays | 2 |
| W | Steve McCatty (13-6) |
| L | Juan Berenguer (2-11) |
Standings Up to and Including this Date
AL East Division
AL West Division
NL East Division
AL Overall
| Tm | W | L | GB | RS | RA | pythW-L% | |
|---|---|---|---|---|---|---|---|
| OAK | 58 | 41 | .586 | -- | 417 | 366 | .559 |
| DET | 57 | 42 | .576 | 1.0 | 389 | 366 | .528 |
| NYY | 55 | 42 | .567 | 2.0 | 388 | 313 | .597 |
| MIL | 56 | 43 | .566 | 2.0 | 450 | 419 | .533 |
| BOS | 54 | 43 | .557 | 3.0 | 463 | 426 | .538 |
| BAL | 52 | 42 | .553 | 3.5 | 396 | 393 | .503 |
| TEX | 51 | 43 | .543 | 4.5 | 414 | 348 | .579 |
| CHW | 47 | 47 | .500 | 8.5 | 412 | 367 | .553 |
| CLE | 46 | 46 | .500 | 8.5 | 384 | 390 | .493 |
| KCR | 43 | 48 | .473 | 11.0 | 332 | 365 | .457 |
| CAL | 45 | 54 | .455 | 13.0 | 419 | 412 | .508 |
| SEA | 38 | 60 | .388 | 19.5 | 386 | 477 | .404 |
| MIN | 37 | 61 | .378 | 20.5 | 332 | 430 | .384 |
| TOR | 35 | 62 | .361 | 22.0 | 309 | 419 | .364 |
NL Overall
| Tm | W | L | GB | RS | RA | pythW-L% | |
|---|---|---|---|---|---|---|---|
| CIN | 59 | 38 | .608 | -- | 422 | 403 | .521 |
| LAD | 58 | 40 | .592 | 1.5 | 413 | 320 | .615 |
| STL | 52 | 38 | .578 | 3.5 | 397 | 354 | .552 |
| HOU | 55 | 43 | .561 | 4.5 | 358 | 296 | .586 |
| MON | 52 | 44 | .542 | 6.5 | 399 | 360 | .547 |
| PHI | 51 | 44 | .537 | 7.0 | 417 | 409 | .509 |
| SFG | 49 | 50 | .495 | 11.0 | 376 | 366 | .512 |
| ATL | 45 | 49 | .479 | 12.5 | 354 | 369 | .481 |
| PIT | 42 | 47 | .472 | 13.0 | 361 | 363 | .497 |
| NYM | 37 | 55 | .402 | 19.5 | 310 | 385 | .402 |
| CHC | 33 | 58 | .363 | 23.0 | 312 | 425 | .362 |
| SDP | 36 | 63 | .364 | 24.0 | 353 | 422 | .419 |


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