MLB Scores and Standings Wednesday, May 21, 1980
| Minnesota Twins | 3 | Final |
| Chicago White Sox | 2 |
| W | Geoff Zahn (3-5) |
| L | Steve Trout (1-4) |
| Baltimore Orioles | 2 | Final |
| Cleveland Indians | 4 |
| W | Len Barker (5-2) |
| L | Mike Flanagan (4-3) |
| S | Sid Monge (4) |
| New York Yankees | 9 | Final |
| Detroit Tigers | 5 | (11) |
| W | Rudy May (2-1) |
| L | Aurelio López (3-3) |
| Oakland Athletics | 4 | Final |
| Kansas City Royals | 2 | (14) |
| W | Bob Lacey (1-0) |
| L | Dan Quisenberry (2-2) |
| St. Louis Cardinals | 3 | Final |
| Los Angeles Dodgers | 5 |
| W | Joe Beckwith (3-0) |
| L | Mark Littell (0-2) |
| S | Bobby Castillo (2) |
| Atlanta Braves | 2 | Final |
| Montreal Expos | 3 |
| W | Steve Rogers (4-4) |
| L | Gene Garber (1-4) |
| Houston Astros | 1 | Final |
| New York Mets | 5 |
| W | Pete Falcone (3-2) |
| L | J.R. Richard (4-3) |
| S | Neil Allen (7) |
| Cincinnati Reds | 8 | Final |
| Philadelphia Phillies | 9 |
| W | Ron Reed (2-0) |
| L | Tom Hume (3-4) |
| San Diego Padres | 3 | Final |
| Pittsburgh Pirates | 4 |
| W | Enrique Romo (2-0) |
| L | Rollie Fingers (4-4) |
| San Diego Padres | 2 | Final |
| Pittsburgh Pirates | 3 |
| W | Grant Jackson (3-1) |
| L | John Curtis (3-3) |
| S | Kent Tekulve (5) |
| Milwaukee Brewers | 5 | Final |
| Seattle Mariners | 6 |
| W | Jim Beattie (3-3) |
| L | Mike Caldwell (3-2) |
| S | Dave Heaverlo (3) |
| Chicago Cubs | 1 | Final |
| San Francisco Giants | 4 |
| W | Vida Blue (6-2) |
| L | Rick Reuschel (3-4) |
| California Angels | 9 | Final |
| Texas Rangers | 8 |
| W | Mark Clear (2-2) |
| L | Jim Kern (2-5) |
| Boston Red Sox | 11 | Final |
| Toronto Blue Jays | 2 |
| W | Mike Torrez (1-4) |
| L | Jesse Jefferson (2-2) |
Standings Up to and Including this Date
AL East Division
AL West Division
NL East Division
AL Overall
| Tm | W | L | GB | RS | RA | pythW-L% | |
|---|---|---|---|---|---|---|---|
| NYY | 21 | 14 | .600 | -- | 178 | 140 | .608 |
| CHW | 22 | 16 | .579 | 0.5 | 163 | 164 | .497 |
| TOR | 19 | 15 | .559 | 1.5 | 147 | 133 | .546 |
| KCR | 20 | 16 | .556 | 1.5 | 155 | 167 | .466 |
| OAK | 20 | 17 | .541 | 2.0 | 158 | 140 | .555 |
| BOS | 19 | 18 | .514 | 3.0 | 181 | 202 | .450 |
| TEX | 18 | 18 | .500 | 3.5 | 173 | 161 | .533 |
| SEA | 19 | 20 | .487 | 4.0 | 156 | 175 | .448 |
| MIL | 16 | 18 | .471 | 4.5 | 194 | 156 | .598 |
| CAL | 16 | 19 | .457 | 5.0 | 137 | 145 | .474 |
| DET | 16 | 19 | .457 | 5.0 | 173 | 169 | .511 |
| BAL | 16 | 21 | .432 | 6.0 | 153 | 153 | .500 |
| CLE | 15 | 20 | .429 | 6.0 | 129 | 177 | .359 |
| MIN | 16 | 22 | .421 | 6.5 | 172 | 187 | .462 |
NL Overall
| Tm | W | L | GB | RS | RA | pythW-L% | |
|---|---|---|---|---|---|---|---|
| LAD | 24 | 13 | .649 | -- | 165 | 144 | .562 |
| PIT | 21 | 12 | .636 | 1.0 | 142 | 116 | .591 |
| HOU | 20 | 15 | .571 | 3.0 | 137 | 118 | .568 |
| CIN | 21 | 16 | .568 | 3.0 | 169 | 158 | .531 |
| PHI | 17 | 15 | .531 | 4.5 | 172 | 139 | .596 |
| MON | 17 | 16 | .515 | 5.0 | 131 | 141 | .466 |
| SDP | 18 | 19 | .486 | 6.0 | 121 | 128 | .474 |
| CHC | 15 | 18 | .455 | 7.0 | 147 | 147 | .500 |
| SFG | 16 | 22 | .421 | 8.5 | 135 | 161 | .420 |
| NYM | 13 | 20 | .394 | 9.0 | 117 | 144 | .406 |
| STL | 14 | 22 | .389 | 9.5 | 171 | 163 | .522 |
| ATL | 13 | 21 | .382 | 9.5 | 110 | 158 | .340 |
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