MLB Scores and Standings Monday, May 16, 1910
| Detroit Tigers | 4 | Final |
| Boston Red Sox | 11 |
| W | Ed Karger (3-1) |
| L | Hub Pernoll (2-3) |
| Boston Doves | 3 | Final |
| Chicago Cubs | 4 |
| W | King Cole (2-0) |
| L | Buster Brown (2-2) |
| Brooklyn Superbas | 2 | Final |
| Cincinnati Reds | 3 |
| W | Art Fromme (2-0) |
| L | George Bell (1-5) |
| S | Harry Gaspar (1) |
| St. Louis Browns | 3 | Final |
| New York Highlanders | 5 |
| W | Russ Ford (4-0) |
| L | Joe Lake (2-2) |
| Chicago White Sox | 1 | Final |
| Philadelphia Athletics | 6 |
| W | Jack Coombs (2-2) |
| L | Frank Smith (3-4) |
| Philadelphia Phillies | 4 | Final |
| Pittsburgh Pirates | 7 |
| W | Lefty Leifield (2-2) |
| L | Lou Schettler (0-1) |
| S | Kirby White (1) |
| New York Giants | 2 | Final |
| St. Louis Cardinals | 4 |
| W | Vic Willis (3-3) |
| L | Hooks Wiltse (3-2) |
| Cleveland Naps | 1 | Final |
| Washington Nationals | 3 |
| W | Doc Reisling (1-1) |
| L | Cy Falkenberg (2-2) |
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