MLB Scores and Standings Monday, September 27, 2021
| Pittsburgh Pirates | 1 | Final |
| Cincinnati Reds | 13 |
| W | Reiver Sanmartin (1-0) |
| L | Connor Overton (0-1) |
| Kansas City Royals | 3 | Final |
| Cleveland Indians | 8 |
| W | Cal Quantrill (8-3) |
| L | Jackson Kowar (0-5) |
| Chicago White Sox | 8 | Final |
| Detroit Tigers | 7 |
| W | Dallas Keuchel (9-9) |
| L | Matt Manning (4-7) |
| S | Liam Hendriks (37) |
| Washington Nationals | 5 | Final |
| Colorado Rockies | 4 |
| W | Josiah Gray (2-2) |
| L | Germán Márquez (12-11) |
| S | Tanner Rainey (3) |
| Oakland Athletics | 4 | Final |
| Seattle Mariners | 13 |
| W | Chris Flexen (14-6) |
| L | Cole Irvin (10-15) |
Standings Up to and Including this Date
AL East Division
AL Central Division
AL West Division
NL East Division
NL Central Division
AL Overall
| Tm | W | L | GB | RS | RA | pythW-L% | |
|---|---|---|---|---|---|---|---|
| TBR | 97 | 59 | .622 | -- | 829 | 638 | .618 |
| HOU | 91 | 65 | .583 | 6.0 | 833 | 628 | .626 |
| NYY | 89 | 67 | .571 | 8.0 | 687 | 643 | .530 |
| CHW | 89 | 68 | .567 | 8.5 | 768 | 624 | .594 |
| BOS | 88 | 68 | .564 | 9.0 | 803 | 729 | .544 |
| TOR | 87 | 69 | .558 | 10.0 | 808 | 636 | .608 |
| SEA | 87 | 70 | .554 | 10.5 | 679 | 731 | .466 |
| OAK | 85 | 72 | .541 | 12.5 | 721 | 656 | .543 |
| CLE | 77 | 79 | .494 | 20.0 | 685 | 697 | .492 |
| DET | 75 | 81 | .481 | 22.0 | 673 | 726 | .465 |
| LAA | 74 | 82 | .474 | 23.0 | 695 | 780 | .447 |
| KCR | 71 | 85 | .455 | 26.0 | 655 | 756 | .435 |
| MIN | 69 | 87 | .442 | 28.0 | 697 | 806 | .434 |
| TEX | 57 | 99 | .365 | 40.0 | 598 | 783 | .379 |
| BAL | 50 | 106 | .321 | 47.0 | 640 | 918 | .341 |
NL Overall
| Tm | W | L | GB | RS | RA | pythW-L% | |
|---|---|---|---|---|---|---|---|
| SFG | 102 | 54 | .654 | -- | 776 | 579 | .631 |
| LAD | 100 | 56 | .641 | 2.0 | 783 | 536 | .667 |
| MIL | 94 | 62 | .603 | 8.0 | 717 | 587 | .591 |
| STL | 87 | 69 | .558 | 15.0 | 685 | 651 | .523 |
| ATL | 83 | 72 | .535 | 18.5 | 762 | 641 | .578 |
| CIN | 82 | 75 | .522 | 20.5 | 770 | 727 | .526 |
| PHI | 81 | 75 | .519 | 21.0 | 718 | 723 | .497 |
| SDP | 78 | 78 | .500 | 24.0 | 709 | 671 | .525 |
| NYM | 73 | 82 | .471 | 28.5 | 606 | 645 | .471 |
| COL | 71 | 85 | .455 | 31.0 | 711 | 767 | .465 |
| CHC | 67 | 89 | .429 | 35.0 | 675 | 818 | .413 |
| WSN | 65 | 92 | .414 | 37.5 | 708 | 791 | .449 |
| MIA | 64 | 91 | .413 | 37.5 | 606 | 670 | .454 |
| PIT | 58 | 98 | .372 | 44.0 | 579 | 801 | .356 |
| ARI | 50 | 106 | .321 | 52.0 | 648 | 866 | .370 |


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