MLB Scores and Standings Wednesday, September 22, 2021
| Toronto Blue Jays | 1 | Final |
| Tampa Bay Rays | 7 |
| W | JT Chargois (6-1) |
| L | Ross Stripling (5-7) |
| Washington Nationals | 7 | Final |
| Miami Marlins | 5 |
| W | Josiah Gray (1-2) |
| L | Elieser Hernández (1-3) |
| S | Tanner Rainey (2) |
| Texas Rangers | 3 | Final |
| New York Yankees | 7 |
| W | Chad Green (9-7) |
| L | Spencer Patton (1-2) |
| Baltimore Orioles | 3 | Final |
| Philadelphia Phillies | 4 |
| W | José Alvarado (7-1) |
| L | Conner Greene (1-2) |
| S | Ian Kennedy (25) |
| New York Mets | 5 | Final |
| Boston Red Sox | 12 |
| W | Chris Sale (5-0) |
| L | Taijuan Walker (7-11) |
| Minnesota Twins | 5 | Final |
| Chicago Cubs | 4 |
| W | Joe Ryan (2-1) |
| L | Kyle Hendricks (14-7) |
| S | Alex Colomé (15) |
| St. Louis Cardinals | 10 | Final |
| Milwaukee Brewers | 2 |
| W | Miles Mikolas (2-2) |
| L | Brett Anderson (4-9) |
| Los Angeles Dodgers | 5 | Final |
| Colorado Rockies | 10 |
| W | Robert Stephenson (2-1) |
| L | Justin Bruihl (0-1) |
| Houston Astros | 9 | Final |
| Los Angeles Angels | 5 | (12) |
| W | Yimi GarcĂa (4-9) |
| L | Sam Selman (0-1) |
| Atlanta Braves | 9 | Final |
| Arizona Diamondbacks | 2 |
| W | Ian Anderson (8-5) |
| L | Merrill Kelly (7-11) |
| Seattle Mariners | 4 | Final |
| Oakland Athletics | 1 |
| W | Chris Flexen (13-6) |
| L | Cole Irvin (10-14) |
| S | Drew Steckenrider (11) |
| San Francisco Giants | 8 | Final |
| San Diego Padres | 6 |
| W | Camilo Doval (4-1) |
| L | Vince Velasquez (3-8) |
Standings Up to and Including this Date
AL East Division
AL Central Division
AL West Division
NL East Division
NL Central Division
AL Overall
| Tm | W | L | GB | RS | RA | pythW-L% | |
|---|---|---|---|---|---|---|---|
| TBR | 94 | 59 | .614 | -- | 811 | 633 | .611 |
| HOU | 91 | 61 | .599 | 2.5 | 825 | 605 | .638 |
| BOS | 88 | 65 | .575 | 6.0 | 794 | 710 | .551 |
| CHW | 85 | 66 | .563 | 8.0 | 744 | 602 | .596 |
| NYY | 86 | 67 | .562 | 8.0 | 668 | 634 | .524 |
| TOR | 85 | 67 | .559 | 8.5 | 794 | 623 | .609 |
| SEA | 83 | 69 | .546 | 10.5 | 648 | 702 | .463 |
| OAK | 82 | 70 | .539 | 11.5 | 692 | 631 | .542 |
| CLE | 74 | 76 | .493 | 18.5 | 662 | 678 | .489 |
| DET | 74 | 78 | .487 | 19.5 | 659 | 712 | .465 |
| LAA | 72 | 80 | .474 | 21.5 | 672 | 766 | .440 |
| KCR | 69 | 83 | .454 | 24.5 | 646 | 741 | .438 |
| MIN | 67 | 85 | .441 | 26.5 | 684 | 792 | .433 |
| TEX | 55 | 97 | .362 | 38.5 | 581 | 768 | .375 |
| BAL | 48 | 104 | .316 | 45.5 | 625 | 901 | .339 |
NL Overall
| Tm | W | L | GB | RS | RA | pythW-L% | |
|---|---|---|---|---|---|---|---|
| SFG | 99 | 53 | .651 | -- | 750 | 566 | .626 |
| LAD | 97 | 55 | .638 | 2.0 | 767 | 522 | .669 |
| MIL | 91 | 61 | .599 | 8.0 | 697 | 573 | .589 |
| STL | 82 | 69 | .543 | 16.5 | 645 | 630 | .511 |
| ATL | 80 | 71 | .530 | 18.5 | 740 | 624 | .577 |
| PHI | 78 | 74 | .513 | 21.0 | 695 | 705 | .493 |
| CIN | 78 | 74 | .513 | 21.0 | 731 | 708 | .515 |
| SDP | 77 | 75 | .507 | 22.0 | 691 | 647 | .530 |
| NYM | 73 | 79 | .480 | 26.0 | 600 | 630 | .478 |
| COL | 71 | 80 | .470 | 27.5 | 696 | 735 | .475 |
| CHC | 67 | 85 | .441 | 32.0 | 659 | 786 | .420 |
| MIA | 64 | 88 | .421 | 35.0 | 601 | 652 | .463 |
| WSN | 63 | 89 | .414 | 36.0 | 685 | 761 | .452 |
| PIT | 57 | 94 | .377 | 41.5 | 560 | 765 | .361 |
| ARI | 48 | 104 | .316 | 51.0 | 633 | 853 | .367 |


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