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Single-Season Top 50 Leaders
| 1. | A.J. Burnett • 2002 | 5 |
| Dontrelle Willis • 2005 | 5 | |
| 3. | Henderson Alvarez III • 2014 | 3 |
| Kevin Brown • 1996 | 3 | |
| 5. | Sandy Alcantara • 2019 | 2 |
| Kevin Brown • 1997 | 2 | |
| A.J. Burnett • 2005 | 2 | |
| Chris Hammond • 1995 | 2 | |
| Ricky Nolasco • 2012 | 2 | |
| Carl Pavano • 2004 | 2 | |
| Pat Rapp • 1995 | 2 | |
| Anibal Sanchez • 2011 | 2 | |
| Jesus Sanchez • 2000 | 2 | |
| Dennis Springer • 1999 | 2 | |
| Dontrelle Willis • 2003 | 2 | |
| 16. | Henderson Alvarez III • 2013 | 1 |
| Josh Beckett • 2004 | 1 | |
| Josh Beckett • 2005 | 1 | |
| Ryan Bowen • 1993 | 1 | |
| A.J. Burnett • 2001 | 1 | |
| Ryan Dempster • 2000 | 1 | |
| Ryan Dempster • 2001 | 1 | |
| Alex Fernandez • 1997 | 1 | |
| Mark Gardner • 1995 | 1 | |
| Chris Hammond • 1994 | 1 | |
| Charlie Hough • 1994 | 1 | |
| Al Leiter • 1996 | 1 | |
| Ricky Nolasco • 2008 | 1 | |
| Ricky Nolasco • 2011 | 1 | |
| Brad Penny • 2001 | 1 | |
| Brad Penny • 2002 | 1 | |
| Pat Rapp • 1994 | 1 | |
| Pat Rapp • 1997 | 1 | |
| Anibal Sanchez • 2006 | 1 | |
| Anibal Sanchez • 2010 | 1 | |
| Javier Vazquez • 2011 | 1 | |
| Edinson Volquez • 2017 | 1 | |
| Chris Volstad • 2009 | 1 | |
| Chris Volstad • 2010 | 1 | |
| Dontrelle Willis • 2006 | 1 | |
| Carlos Zambrano • 2012 | 1 |
Data Notes