MLB Probable Pitchers for Friday, September 22, 2017
| Cardinals (80-72) | Preview | |
| Pirates (69-84) | 7:05PM |
| STL | Michael Wacha (#52, 25, RHP, 12-8, 4.02) |
| PIT | Ivan Nova (#46, 30, RHP, 11-14, 4.20) |
| Rays (74-79) | Preview | |
| Orioles (74-80) | 7:05PM |
| TBR | Alex Cobb (#53, 29, RHP, 11-10, 3.63) |
| BAL | Ubaldo Jimenez (#31, 33, RHP, 6-10, 6.57) |
| Yankees (85-67) | Preview | |
| Blue Jays (71-82) | 7:07PM |
| NYY | Masahiro Tanaka (#19, 28, RHP, 12-11, 4.73) |
| TOR | Marco Estrada (#25, 33, RHP, 9-8, 4.84) |
| Twins (79-74) | Preview | |
| Tigers (62-91) | 7:10PM |
| MIN | Kyle Gibson (#44, 29, RHP, 11-10, 5.07) |
| DET | Daniel Norris (#44, 24, LHP, 4-7, 5.38) |
| Red Sox (88-64) | Preview | |
| Reds (66-87) | 7:10PM |
| BOS | Rick Porcello (#22, 28, RHP, 10-17, 4.46) |
| CIN | Sal Romano (#47, 23, RHP, 5-6, 4.07) |
| Nationals (92-60) | Preview | |
| Mets (65-87) | 7:10PM |
| WSN | Edwin Jackson (#40, 33, RHP, 5-6, 4.96) |
| NYM | Robert Gsellman (#65, 23, RHP, 7-7, 5.22) |
| Phillies (61-92) | Preview | |
| Braves (68-83) | 7:35PM |
| PHI | Ben Lively (#49, 25, RHP, 3-6, 3.94) |
| ATL | Sean Newcomb (#51, 24, LHP, 3-8, 4.32) |
| Cubs (85-67) | Preview | |
| Brewers (81-72) | 7:35PM |
| CHC | John Lackey (#41, 38, RHP, 11-11, 4.62) |
| MIL | Brandon Woodruff (#53, 24, RHP, 2-2, 3.28) |
| Royals (75-77) | Preview | |
| White Sox (61-91) | 8:10PM |
| KCR | Jason Hammel (#39, 34, RHP, 8-12, 5.05) |
| CHW | Reynaldo Lopez (#40, 23, RHP, 2-3, 4.84) |
| Angels (76-76) | Preview | |
| Astros (93-59) | 8:10PM |
| LAA | Garrett Richards (#43, 29, RHP, 0-2, 2.00) |
| HOU | Justin Verlander (#35, 34, RHP, 13-8, 3.50) |
| Marlins (72-80) | Preview | |
| D'backs (88-65) | 9:40PM |
| MIA | Adam Conley (#61, 27, LHP, 7-7, 5.20) |
| ARI | Zack Greinke (#21, 33, RHP, 17-6, 2.87) |
| Rangers (76-76) | Preview | |
| Athletics (69-83) | 10:05PM |
| TEX | Nick Martinez (#22, 26, RHP, 3-6, 5.47) |
| OAK | Kendall Graveman (#49, 26, RHP, 5-4, 4.39) |
| Rockies (82-71) | Preview | |
| Padres (69-84) | 10:10PM |
| COL | Jon Gray (#55, 25, RHP, 8-4, 3.75) |
| SDP | Jordan Lyles (#27, 26, RHP, 1-3, 7.35) |
| Indians (96-57) | Preview | |
| Mariners (74-79) | 10:10PM |
| CLE | Trevor Bauer (#47, 26, RHP, 16-9, 4.41) |
| SEA | Erasmo Ramirez (#31, 27, RHP, 5-6, 4.56) |
| Giants (60-93) | Preview | |
| Dodgers (97-56) | 10:10PM |
| SFG | Jeff Samardzija (#29, 32, RHP, 9-14, 4.42) |
| LAD | Rich Hill (#44, 37, LHP, 10-8, 3.60) |
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