| Postseason: |
Won World Series (4-1) over Chicago Cubs |

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Transactions listed are from November 1 of previous year to April 1 of the following year.
December 1, 1909
Traded Simon Nicholls to the Cleveland Naps. Received Wilbur Good. (Date given is approximate. Exact date is uncertain.)
March 30, 1910
Sold Wilbur Good to Baltimore (Eastern).
June 10, 1910 (Standings)
Purchased Pat Donahue from the Boston Red Sox.
July 18, 1910 (Standings)
Purchased Lefty Russell from Baltimore (Eastern) for $12,000.
July 23, 1910 (Standings)
Traded a player to be named later and Morrie Rath to the Cleveland Naps. Received Bris Lord. The Philadelphia Athletics sent Joe Jackson (July 30, 1910) to the Cleveland Naps to complete the trade.
September 1, 1910 (Standings)
Drafted Allan Collamore from Worcester (New England) in the 1910 rule 5 draft.
Drafted Steve O'Neill from Elmira (New York State) in the 1910 rule 5 draft.