| Postseason: |
Lost World Series (4-0-1) to New York Giants |

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Transactions listed are from November 1 of previous year to April 1 of the following year.
December 20, 1921
Traded Rip Collins, Roger Peckinpaugh, Bill Piercy and Jack Quinn to the Boston Red Sox. Received Joe Bush, Sam Jones and Everett Scott.
February 24, 1922
Alex Ferguson selected by the Boston Red Sox off waivers.
April 17, 1922 (Standings)
Purchased Whitey Witt from the Philadelphia Athletics.
July 23, 1922 (Standings)
Traded Chick Fewster, Elmer Miller, Johnny Mitchell, Lefty O'Doul and $50,000 to the Boston Red Sox. Received Joe Dugan and Elmer Smith.
January 3, 1923
Traded Al DeVormer and cash to the Boston Red Sox. Received Harvey Hendrick and George Pipgras.
January 30, 1923
Traded Norm McMillan, George Murray, Camp Skinner and $50,000 to the Boston Red Sox. Received Herb Pennock.