| Postseason: |
Lost World Series (5-3) to New York Giants |

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Transactions listed are from November 1 of previous year to April 1 of the following year.
December 15, 1920
Traded Del Pratt, Muddy Ruel, Hank Thormahlen and Sammy Vick to the Boston Red Sox. Received Harry Harper, Waite Hoyt, Mike McNally and Wally Schang.
December 31, 1920
Traded Duffy Lewis and George Mogridge to the Washington Senators. Received Braggo Roth.
December 20, 1921
Traded Rip Collins, Roger Peckinpaugh, Bill Piercy and Jack Quinn to the Boston Red Sox. Received Joe Bush, Sam Jones and Everett Scott.
February 24, 1922
Alex Ferguson selected by the Boston Red Sox off waivers.