| Postseason: |
Lost World Series (4-1) to Philadelphia Athletics |

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Transactions listed are from November 1 of previous year to April 1 of the following year.
February 1, 1910
Traded Fred Liese and cash to the Boston Doves. Received Ginger Beaumont.
April 13, 1910 (Standings)
Traded Bill Davidson, Happy Smith and Tony Smith to the Brooklyn Superbas. Received Harry McIntire.
May 10, 1910 (Standings)
Sold Pat Moran to the Philadelphia Phillies.
May 13, 1910 (Standings)
Traded Doc Miller to the Boston Doves. Received Lew Richie.
July 18, 1910 (Standings)
Purchased Vic Saier from Lansing (Southern Michigan) for $1,500.
July 29, 1910 (Standings)
Traded Fred Luderus to the Philadelphia Phillies. Received Bill Foxen.
August, 1910 (Standings)
Purchased Fred Toney from Winchester (Blue Grass) for $1,000.
August 18, 1910 (Standings)
Purchased Jim Doyle from Louisville (American Association).
August 26, 1910 (Standings)
Sold Rube Kroh to Louisville (American Association).
September 1, 1910 (Standings)
Drafted Hank Griffin from Atlanta (Southern Association) in the 1910 rule 5 draft.
Drafted Al Kaiser from Paris (Blue Grass) in the 1910 rule 5 draft.
Drafted Bill James from Jackson (Southern Michigan) in the 1910 rule 5 draft.
Drafted Orlie Weaver from Jacksonville (South Atlantic) in the 1910 rule 5 draft.
1911
Bill James sent to the Cleveland Naps in an unknown transaction.
February 25, 1911
Traded Scotty Ingerton and Big Jeff Pfeffer to the Boston Rustlers. Received Dave Shean.