Transactions listed are from November 1 of previous year to April 1 of the following year.
The Philadelphia Phillies purchased Johnny Enzmann from the Cleveland Indians.
The Detroit Tigers purchased Babe Pinelli from the Chicago White Sox.
The St. Louis Cardinals signed Jim Bottomley as a free agent.
The St. Louis Cardinals purchased Jack Fournier from Los Angeles (PCL).
The St. Louis Cardinals purchased Jesse Haines from Kansas City (American Association) for $10,000.
The Boston Braves purchased Cy Morgan from Portland (New England).
The Boston Red Sox purchased Tim Hendryx from the St. Louis Browns.
The Philadelphia Phillies purchased Dots Miller from the St. Louis Cardinals.
The Chicago Cubs purchased Zeb Terry from the Pittsburgh Pirates.
The New York Yankees purchased Babe Ruth from the Boston Red Sox for $100,000.
The Philadelphia Phillies purchased Mack Wheat from the Brooklyn Robins.
The Washington Senators traded Eddie Foster, Harry Harper and Mike Menosky to the Boston Red Sox for Braggo Roth and Red Shannon.
The New York Giants purchased Fred Lear from the Chicago Cubs.
Los Angeles (PCL) purchased Ray Keating from the Boston Braves.
The Brooklyn Robins purchased Bill Lamar from the Boston Red Sox.
The Boston Braves purchased Frank Miller from the Pittsburgh Pirates.
The St. Louis Cardinals released Red Ames.
The Boston Red Sox purchased Gene Bailey from the Boston Braves.
The Boston Braves purchased Mule Watson from New Haven (Eastern).
The Philadelphia Phillies purchased Bert Gallia from the St. Louis Browns.
The Brooklyn Robins purchased Bill McCabe from the Chicago Cubs.
The Pittsburgh Pirates selected Mule Watson off waivers from the Boston Braves.
The Cleveland Indians purchased George Burns from the Philadelphia Athletics.
The Boston Red Sox selected Elmer Myers off waivers from the Cleveland Indians.
The Boston Red Sox selected Jigger Statz off waivers from the New York Giants.
The New York Giants traded Art Fletcher, Bill Hubbell and cash to the Philadelphia Phillies for Dave Bancroft.
The Philadelphia Phillies purchased Johnny Rawlings from the Boston Braves.
The Boston Braves selected Mule Watson off waivers from the Pittsburgh Pirates.
The St. Louis Cardinals signed Ed Hock as a free agent. (Date given is approximate. Exact date is uncertain.)
The Pittsburgh Pirates purchased Wally Hood from the Brooklyn Robins.
The Washington Senators traded Red Shannon to the Philadelphia Athletics for Fred Thomas.
The New York Giants traded Benny Kauff and cash to Toronto (International) for Vern Spencer.
The Cincinnati Reds purchased Ed Sicking from the New York Giants.
Toronto (International) purchased Bunny Hearn from the Boston Braves.
The St. Louis Cardinals purchased Lew McCarty from the New York Giants.
The Chicago White Sox selected Amos Strunk off waivers from the Philadelphia Athletics.
The New York Giants purchased Doug Baird from the Brooklyn Robins.
The Washington Senators traded Molly Craft, Bill Snyder and cash to Toronto (International) for Frank O'Rourke.
The Chicago White Sox purchased Shovel Hodge from Nashville (Southern Association).
The Chicago White Sox purchased Bubber Jonnard from Nashville (Southern Association).
The Boston Braves signed Ira Townsend as an amateur free agent.
The New York Giants purchased Red Shea from Toronto (International) for $12,000.
The Boston Braves purchased Frank Gibson from San Antonio (Texas).
The New York Yankees traded Howie Camp and additional compensation to Vernon (PCL) for Johnny Mitchell.
The Boston Braves purchased Maurice Archdeacon from Charleston (South Atlantic). (Date given is approximate. Exact date is uncertain.)
The Pittsburgh Pirates purchased Pie Traynor from Portsmouth (Virginia) for $10,000.
The Boston Braves purchased Leo Townsend from Charleston (South Atlantic).
The New York Giants selected Slim Sallee off waivers from the Cincinnati Reds.
The Cleveland Indians purchased Joe Sewell from New Orleans (Southern Association).
The New York Yankees purchased Tom Sheehan from Atlanta (Southern Association).
The Boston Braves purchased Red Torphy from New Haven (Eastern).
The St. Louis Cardinals selected Al Lefevre off waivers from the New York Giants.
The St. Louis Cardinals purchased Les Mann from the Boston Braves.
San Francisco (PCL) traded Bert Cole to the Detroit Tigers for Babe Ellison.
The Philadelphia Phillies traded Eppa Rixey to the Cincinnati Reds for Greasy Neale and Jimmy Ring.
The Cincinnati Reds selected Dode Paskert off waivers from the Chicago Cubs.
The New York Yankees traded Del Pratt, Muddy Ruel, Hank Thormahlen and Sammy Vick to the Boston Red Sox for Harry Harper, Waite Hoyt, Mike McNally and Wally Schang.
The Cincinnati Reds traded Dutch Ruether to the Brooklyn Robins for Rube Marquard.
The Washington Senators traded Braggo Roth to the New York Yankees for Duffy Lewis and George Mogridge.
The Boston Braves traded a player to be named later and cash to Beaumont (Texas) for a player to be named later and Al Nixon. The Boston Braves sent Pep Ripper (minors) (May 12, 1921) to Beaumont (Texas) to complete the trade.
The Detroit Tigers signed Heinie Manush as a free agent.
The Pittsburgh Pirates traded Walter Barbare, Fred Nicholson, Billy Southworth and $15,000 to the Boston Braves for Rabbit Maranville.
The Chicago Cubs released Claude Hendrix.
The Chicago White Sox traded Shano Collins and Nemo Leibold to the Boston Red Sox for Harry Hooper.
Columbus (American Association) purchased Art Wilson from the Boston Braves.