+ - Indicates Hall of Famer. Bold indicates active player.
Statistic Description: Win-Loss Percentage W / (W + L) For players, leaders need one decision for every ten team games. For managers, minimum to qualify for leading is 320 games.
Minimum of 1000 IP, 3000 PA, 500 games (fielding), 200 stolen base attempts (catchers) or 80 stolen base attempts (baserunners only since 1951) or 100 decisions for career and active leaderboards for rate statistics.
| Rank | Player (yrs, age) | Win-Loss % | Throws |
|---|---|---|---|
| 1. | Roy Halladay (15, 35) | .6656 | R |
| 2. | Jered Weaver (7, 29) | .6623 | R |
| 3. | Justin Verlander (8, 29) | .6561 | R |
| 4. | Tim Hudson (14, 36) | .6545 | R |
| 5. | CC Sabathia (12, 31) | .6519 | L |
| 6. | Johan Santana (12, 33) | .6406 | L |
| 7. | Jon Lester (7, 28) | .6391 | L |
| 8. | Andy Pettitte (17, 40) | .6331 | L |
| 9. | Roy Oswalt (12, 34) | .6293 | R |
| 10. | Adam Wainwright (7, 30) | .6250 | R |
| 11. | Yovani Gallardo (6, 26) | .6161 | R |
| 12. | Cliff Lee (11, 33) | .6158 | L |
| 13. | Chris Carpenter (15, 37) | .6050 | R |
| 14. | Cole Hamels (7, 28) | .6026 | L |
| 15. | Freddy Garcia (14, 35) | .6008 | R |
| 16. | Carlos Zambrano (12, 31) | .5919 | R |
| 17. | Tim Lincecum (6, 28) | .5852 | R |
| 18. | Bartolo Colon (15, 39) | .5836 | R |
| 19. | Josh Beckett (12, 32) | .5815 | R |
| 20. | John Lackey (10, 33) | .5766 | R |
| 21. | Mark Buehrle (13, 33) | .5686 | L |
| 22. | Scott Baker (7, 30) | .5676 | R |
| 23. | Chad Billingsley (7, 27) | .5674 | R |
| 24. | Mariano Rivera (18, 42) | .5672 | R |
| 25. | Johnny Cueto (5, 26) | .5660 | R |
| 26. | Jake Peavy (11, 31) | .5634 | R |
| 27. | Felix Hernandez (8, 26) | .5632 | R |
| 28. | Jamie Moyer (25, 49) | .5628 | L |
| 29. | C.J. Wilson (8, 31) | .5545 | L |
| 30. | Dan Haren (10, 31) | .5509 | R |
| 31. | Darren Oliver (19, 41) | .5502 | L |
| 32. | Barry Zito (13, 34) | .5479 | L |
| 33. | Ervin Santana (8, 29) | .5455 | R |
| Joe Saunders (8, 31) | .5455 | L | |
| 35. | James Shields (7, 30) | .5438 | R |
| 36. | Brad Penny (13, 34) | .5434 | R |
| 37. | Ricky Nolasco (7, 29) | .5429 | R |
| 38. | Vicente Padilla (14, 34) | .5427 | R |
| 39. | Octavio Dotel (14, 38) | .5413 | R |
| 40. | Ted Lilly (14, 36) | .5394 | L |
| 41. | Zack Greinke (9, 28) | .5385 | R |
| 42. | Jose Contreras (10, 40) | .5379 | R |
| 43. | Kerry Wood (14, 35) | .5342 | R |
| 44. | A.J. Burnett (14, 35) | .5310 | R |
| 45. | Randy Wolf (14, 35) | .5301 | L |
| 46. | Trevor Cahill (4, 24) | .5300 | R |
| 47. | Joel Pineiro (12, 33) | .5279 | R |
| 48. | Derek Lowe (16, 39) | .5271 | R |
| 49. | Kevin Millwood (16, 37) | .5265 | R |
| 50. | Joe Blanton (9, 31) | .5253 | R |
| Rank | Player (yrs, age) | Win-Loss % | Throws |
| 51. | Matt Cain (8, 27) | .5215 | R |
| 52. | R.A. Dickey (10, 37) | .5214 | R |
| 53. | Kyle Lohse (12, 33) | .5198 | R |
| 54. | Bronson Arroyo (13, 35) | .5188 | R |
| 55. | Gavin Floyd (9, 29) | .5147 | R |
| 56. | Jorge De La Rosa (9, 31) | .5143 | L |
| 57. | Ubaldo Jimenez (7, 28) | .5111 | R |
| 58. | Dontrelle Willis (9, 30) | .5106 | L |
| 59. | Brett Myers (11, 31) | .5105 | R |
| 60. | Jake Westbrook (12, 34) | .5078 | R |
| 61. | Jason Marquis (13, 33) | .5068 | R |
| 62. | Ramon Ortiz (11, 39) | .5059 | R |
| 63. | Aaron Harang (11, 34) | .5024 | R |
| 64. | Carl Pavano (14, 36) | .5023 | R |
| 65. | Livan Hernandez (17, 37) | .5014 | R |
| 66. | Ryan Dempster (15, 35) | .5000 | R |
| Hiroki Kuroda (5, 37) | .5000 | R | |
| 68. | Bruce Chen (14, 35) | .4965 | L |
| Edwin Jackson (10, 28) | .4965 | R | |
| 70. | Erik Bedard (9, 33) | .4961 | L |
| 71. | Francisco Liriano (7, 28) | .4953 | L |
| 72. | Ben Sheets (10, 33) | .4947 | R |
| 73. | Brett Tomko (14, 39) | .4926 | R |
| 74. | Wandy Rodriguez (8, 33) | .4913 | L |
| 75. | Aaron Cook (11, 33) | .4903 | R |
| 76. | Jeff Suppan (17, 37) | .4895 | R |
| 77. | John Danks (6, 27) | .4872 | L |
| 78. | Matt Garza (7, 28) | .4831 | R |
| 79. | Jason Isringhausen (16, 39) | .4811 | R |
| 80. | Mike Pelfrey (7, 28) | .4808 | R |
| 81. | Kevin Correia (10, 31) | .4800 | R |
| 82. | Scott Elarton (10, 36) | .4786 | R |
| Jeff Francis (8, 31) | .4786 | L | |
| 84. | Rodrigo Lopez (11, 36) | .4765 | R |
| 85. | Chris Capuano (8, 33) | .4759 | L |
| 86. | Miguel Batista (18, 41) | .4700 | R |
| Francisco Cordero (14, 37) | .4700 | R | |
| 88. | Doug Davis (13, 36) | .4600 | L |
| 89. | Oliver Perez (10, 30) | .4504 | L |
| 90. | Dave Bush (8, 32) | .4480 | R |
| 91. | Paul Maholm (8, 30) | .4400 | L |
| 92. | Roberto Hernandez (7, 31) | .4344 | R |
| 93. | Nate Robertson (9, 34) | .4254 | L |
| 94. | Daniel Cabrera (6, 31) | .4248 | R |
| LaTroy Hawkins (18, 39) | .4248 | R | |
| 96. | Jamey Wright (17, 37) | .4206 | R |
| 97. | Jeremy Guthrie (9, 33) | .4167 | R |
| 98. | Kip Wells (12, 35) | .4012 | R |
| 99. | Zach Duke (8, 29) | .3984 | L |
| 100. | Kyle Farnsworth (14, 36) | .3922 | R |