+ - Indicates Hall of Famer. Bold indicates active player.
Statistic Description: Win-Loss Percentage W / (W + L) For players, leaders need one decision for every ten team games. For managers, minimum to qualify for leading is 320 games.
Minimum of 1000 IP, 3000 PA, 500 games (fielding), 200 stolen base attempts (catchers) or 80 stolen base attempts (baserunners only since 1951) or 100 decisions for career and active leaderboards for rate statistics.
| Rank | Player (yrs, age) | Win-Loss % | Throws |
|---|---|---|---|
| 1. | Jon Lester (7, 28) | .6752 | L |
| 2. | Roy Halladay (15, 35) | .6644 | R |
| 3. | Johan Santana (12, 33) | .6553 | L |
| 4. | Justin Verlander (8, 29) | .6512 | R |
| 5. | Tim Hudson (14, 36) | .6502 | R |
| 6. | CC Sabathia (12, 31) | .6500 | L |
| 7. | Jered Weaver (7, 29) | .6471 | R |
| 8. | Adam Wainwright (7, 30) | .6364 | R |
| 9. | Andy Pettitte (17, 40) | .6335 | L |
| 10. | Cliff Lee (11, 33) | .6263 | L |
| 11. | Chris Carpenter (14, 37) | .6102 | R |
| 12. | Tim Lincecum (6, 28) | .6068 | R |
| 13. | Carlos Zambrano (12, 31) | .6038 | R |
| 14. | Josh Beckett (12, 32) | .6028 | R |
| 15. | Freddy Garcia (14, 35) | .5992 | R |
| 16. | Cole Hamels (7, 28) | .5985 | L |
| 17. | Jake Peavy (11, 31) | .5838 | R |
| 18. | Bartolo Colon (15, 39) | .5830 | R |
| 19. | John Lackey (10, 33) | .5766 | R |
| 20. | Mark Buehrle (13, 33) | .5744 | L |
| 21. | Scott Baker (7, 30) | .5676 | R |
| 22. | Mariano Rivera (18, 42) | .5672 | R |
| 23. | Chad Billingsley (7, 27) | .5669 | R |
| Joe Saunders (8, 31) | .5669 | L | |
| 25. | Jamie Moyer (25, 49) | .5628 | L |
| 26. | Ricky Nolasco (7, 29) | .5610 | R |
| 27. | Felix Hernandez (8, 26) | .5562 | R |
| 28. | Dan Haren (10, 31) | .5528 | R |
| 29. | Ubaldo Jimenez (7, 28) | .5508 | R |
| 30. | Ervin Santana (8, 29) | .5494 | R |
| 31. | Darren Oliver (19, 41) | .5490 | L |
| 32. | Barry Zito (13, 34) | .5418 | L |
| 33. | James Shields (7, 30) | .5417 | R |
| 34. | Ted Lilly (14, 36) | .5394 | L |
| 35. | Vicente Padilla (14, 34) | .5385 | R |
| 36. | Jose Contreras (10, 40) | .5379 | R |
| 37. | Randy Wolf (14, 35) | .5375 | L |
| 38. | Derek Lowe (16, 39) | .5358 | R |
| 39. | Kevin Millwood (16, 37) | .5355 | R |
| 40. | Joe Blanton (9, 31) | .5347 | R |
| 41. | Kerry Wood (14, 35) | .5342 | R |
| 42. | Octavio Dotel (14, 38) | .5340 | R |
| 43. | Joel Pineiro (12, 33) | .5279 | R |
| 44. | Jorge De La Rosa (8, 31) | .5243 | L |
| 45. | A.J. Burnett (14, 35) | .5232 | R |
| 46. | Brett Myers (11, 31) | .5193 | R |
| 47. | Zack Greinke (9, 28) | .5192 | R |
| 48. | Erik Bedard (9, 33) | .5175 | L |
| 49. | Bronson Arroyo (13, 35) | .5135 | R |
| 50. | Aaron Cook (11, 33) | .5106 | R |
| Rank | Player (yrs, age) | Win-Loss % | Throws |
| Dontrelle Willis (9, 30) | .5106 | L | |
| 52. | Jason Marquis (13, 33) | .5096 | R |
| 53. | Gavin Floyd (9, 29) | .5082 | R |
| 54. | Ramon Ortiz (11, 39) | .5059 | R |
| 55. | Carl Pavano (14, 36) | .5047 | R |
| 56. | Jake Westbrook (12, 34) | .5028 | R |
| 57. | Aaron Harang (11, 34) | .5026 | R |
| 58. | Bruce Chen (14, 35) | .5000 | L |
| Kyle Lohse (12, 33) | .5000 | R | |
| 60. | Livan Hernandez (17, 37) | .4986 | R |
| 61. | Matt Cain (8, 27) | .4966 | R |
| 62. | Chris Capuano (8, 33) | .4961 | L |
| 63. | Wandy Rodriguez (8, 33) | .4936 | L |
| 64. | Brett Tomko (14, 39) | .4926 | R |
| 65. | Edwin Jackson (10, 28) | .4919 | R |
| 66. | Jeff Suppan (17, 37) | .4895 | R |
| 67. | John Danks (6, 27) | .4872 | L |
| 68. | Matt Garza (7, 28) | .4865 | R |
| 69. | Ryan Dempster (15, 35) | .4848 | R |
| 70. | Mike Pelfrey (7, 28) | .4808 | R |
| 71. | Jason Isringhausen (16, 39) | .4804 | R |
| 72. | Jeff Francis (7, 31) | .4803 | L |
| 73. | Scott Elarton (10, 36) | .4786 | R |
| 74. | Rodrigo Lopez (11, 36) | .4765 | R |
| 75. | Miguel Batista (18, 41) | .4744 | R |
| 76. | Doug Davis (13, 36) | .4600 | L |
| 77. | Oliver Perez (9, 30) | .4567 | L |
| 78. | Kevin Correia (10, 31) | .4537 | R |
| 79. | Dave Bush (8, 32) | .4480 | R |
| 80. | Paul Maholm (8, 30) | .4286 | L |
| 81. | Nate Robertson (9, 34) | .4254 | L |
| 82. | Daniel Cabrera (6, 31) | .4248 | R |
| 83. | LaTroy Hawkins (18, 39) | .4228 | R |
| 84. | Jeremy Guthrie (9, 33) | .4188 | R |
| 85. | Jamey Wright (17, 37) | .4143 | R |
| 86. | Kip Wells (11, 35) | .4036 | R |
| 87. | Zach Duke (7, 29) | .3934 | L |