+ - Indicates Hall of Famer. Bold indicates active player.
Statistic Description: 9 x SO / IP For recent years, leaders need 1 IP per team game played
Minimum of 1000 IP, 3000 PA, 500 games (fielding), 200 stolen base attempts (catchers) or 80 stolen base attempts (baserunners only since 1951) or 100 decisions for career and active leaderboards for rate statistics.
| Rank | Player (yrs, age) | Strikeouts per 9 IP | Throws |
|---|---|---|---|
| 1. | Tim Lincecum (7, 29) | 9.7579 | R |
| 2. | Clayton Kershaw (6, 25) | 9.2916 | L |
| 3. | Oliver Perez (11, 31) | 9.0960 | L |
| 4. | Johan Santana (12, 34) | 8.8326 | L |
| 5. | Scott Kazmir (9, 29) | 8.7737 | L |
| 6. | Jake Peavy (12, 32) | 8.7709 | R |
| 7. | Erik Bedard (10, 34) | 8.7636 | L |
| 8. | Cole Hamels (8, 29) | 8.5064 | L |
| 9. | Justin Verlander (9, 30) | 8.4729 | R |
| 10. | Josh Beckett (13, 33) | 8.3427 | R |
| 11. | A.J. Burnett (15, 36) | 8.2874 | R |
| 12. | Felix Hernandez (9, 27) | 8.2843 | R |
| 13. | Mariano Rivera (19, 43) | 8.2361 | R |
| 14. | Jon Lester (8, 29) | 8.1807 | L |
| 15. | Ubaldo Jimenez (8, 29) | 8.0777 | R |
| 16. | Zack Greinke (10, 29) | 8.0341 | R |
| 17. | Chad Billingsley (8, 28) | 7.9407 | R |
| 18. | Ryan Dempster (16, 36) | 7.8682 | R |
| 19. | Kelvim Escobar (12, 37) | 7.8235 | R |
| 20. | CC Sabathia (13, 32) | 7.7800 | L |
| 21. | James Shields (8, 31) | 7.7525 | R |
| 22. | Adam Wainwright (8, 31) | 7.6586 | R |
| 23. | Ted Lilly (15, 37) | 7.6476 | L |
| 24. | Jered Weaver (8, 30) | 7.6052 | R |
| 25. | Matt Garza (7, 29) | 7.5803 | R |
| 26. | Dan Haren (11, 32) | 7.5671 | R |
| 27. | Chris Capuano (9, 34) | 7.5089 | L |
| 28. | Matt Cain (9, 28) | 7.4931 | R |
| 29. | Wandy Rodriguez (9, 34) | 7.4207 | L |
| 30. | Cliff Lee (12, 34) | 7.4146 | L |
| 31. | Ricky Nolasco (8, 30) | 7.3286 | R |
| 32. | Aaron Harang (12, 35) | 7.3068 | R |
| 33. | Brett Myers (12, 32) | 7.2579 | R |
| 34. | Ervin Santana (9, 30) | 7.1220 | R |
| 35. | Jeremy Bonderman (8, 30) | 7.1097 | R |
| 36. | Gavin Floyd (10, 30) | 7.0588 | R |
| 37. | John Lackey (11, 34) | 7.0575 | R |
| 38. | Roy Halladay (16, 36) | 6.9476 | R |
| 39. | Edwin Jackson (11, 29) | 6.9352 | R |
| 40. | Chris Carpenter (15, 38) | 6.8818 | R |
| 41. | Bartolo Colon (16, 40) | 6.8588 | R |
| 42. | Jose Contreras (11, 41) | 6.8096 | R |
| 43. | Bruce Chen (15, 36) | 6.7944 | L |
| 44. | Andy Pettitte (18, 41) | 6.6721 | L |
| 45. | Barry Zito (14, 35) | 6.6158 | L |
| 46. | Kip Wells (12, 36) | 6.4760 | R |
| 47. | Freddy Garcia (15, 36) | 6.4744 | R |
| 48. | R.A. Dickey (11, 38) | 6.3620 | R |
| 49. | Joe Blanton (10, 32) | 6.1209 | R |
| 50. | Tim Hudson (15, 37) | 6.0564 | R |
| Rank | Player (yrs, age) | Strikeouts per 9 IP | Throws |
| 51. | Nate Robertson (9, 35) | 6.0529 | L |
| 52. | Dave Bush (9, 33) | 6.0402 | R |
| 53. | LaTroy Hawkins (19, 40) | 5.9765 | R |
| 54. | Jeff Francis (9, 32) | 5.9350 | L |
| 55. | Esteban Loaiza (14, 41) | 5.9257 | R |
| 56. | Kevin Correia (11, 32) | 5.9000 | R |
| 57. | Darren Oliver (20, 42) | 5.8704 | L |
| 58. | Bronson Arroyo (14, 36) | 5.8539 | R |
| 59. | Derek Lowe (17, 40) | 5.8030 | R |
| 60. | Paul Maholm (9, 31) | 5.7755 | L |
| 61. | Rodrigo Lopez (11, 37) | 5.7638 | R |
| 62. | Miguel Batista (18, 42) | 5.7506 | R |
| 63. | Kyle Lohse (13, 34) | 5.6573 | R |
| 64. | Ramon Ortiz (12, 40) | 5.5962 | R |
| 65. | Jeremy Guthrie (10, 34) | 5.4229 | R |
| 66. | Jason Marquis (14, 34) | 5.3152 | R |
| 67. | Mark Hendrickson (10, 39) | 5.1275 | L |
| 68. | Mark Buehrle (14, 34) | 5.1188 | L |
| 69. | Jamey Wright (18, 38) | 5.0978 | R |
| 70. | Joe Saunders (9, 32) | 5.0783 | L |
| 71. | Jake Westbrook (13, 35) | 5.0659 | R |
| 72. | Jon Garland (13, 33) | 4.8552 | R |
| 73. | Zach Duke (9, 30) | 4.6865 | L |
| 74. | Aaron Cook (11, 34) | 3.6990 | R |