+ - Indicates Hall of Famer. Bold indicates active player.
Statistic Description: SO/BB For recent years, leaders need 1 IP per team game played
Only players who finished in the top 40 for the majors in a season will appear on this list.
Leaders from the current season are only included for rate stats after July 1st.
For batting rate stats, generally a minimum of 3.1 Plate Appearances/G, 1.0 IP/G, 0.5 Gm and Chances/Team Game (fielding), 0.2 SB att/Team Game (catchers), and 0.1 SB att/Team Game (baserunners only since 1951), and 0.1 decision/G for single-season leaderboards generally needed for rate statistics. For pitcher fielding the minimums are reduced by a third. For LF, CF, RF fielding stats, we only have reliable data since 1954, so all leaders are since 1954. Explanation of min. requirements
| Rank | Player (age that year) | Strikeouts / Base On Balls | Year | Throws |
|---|---|---|---|---|
| 1. | Bret Saberhagen (30) | 11.0000 | 1994 | R |
| 2. | Cliff Lee (31) | 10.2778 | 2010 | L |
| 3. | Jim Whitney (26) | 10.0000 | 1884 | R |
| 4. | Jim Whitney (25) | 9.8571 | 1883 | R |
| 5. | Curt Schilling (35) | 9.5758 | 2002 | R |
| 6. | George Bradley (27) | 9.0000 | 1880 | R |
| 7. | Pedro Martinez (28) | 8.8750 | 2000 | R |
| 8. | Greg Maddux (31) | 8.8500 | 1997 | R |
| 9. | Henry Boyle (23) | 8.8000 | 1884 | R |
| 10. | Pedro Martinez (27) | 8.4595 | 1999 | R |
| 11. | Ben Sheets (25) | 8.2500 | 2004 | R |
| 12. | James Burke | 8.2258 | 1884 | |
| 13. | Charlie Sweeney (21) | 8.0238 | 1884 | R |
| 14. | Tommy Bond (28) | 7.9444 | 1884 | R |
| 15. | Carlos Silva (26) | 7.8889 | 2005 | R |
| 16. | Greg Maddux (29) | 7.8696 | 1995 | R |
| 17. | Curt Schilling (34) | 7.5128 | 2001 | R |
| 18. | Cliff Lee (33) | 7.3929 | 2012 | L |
| 19. | George Bradley (31) | 7.3043 | 1884 | R |
| 20. | Roy Halladay (33) | 7.3000 | 2010 | R |
| 21. | Fergie Jenkins+ (28) | 7.1081 | 1971 | R |
| 22. | Cy Young+ (38) | 7.0000 | 1905 | R |
| 23. | Bobby Mathews (30) | 6.9545 | 1882 | R |
| 24. | Jack Lynch (27) | 6.9524 | 1884 | R |
| 25. | Cy Young+ (37) | 6.8966 | 1904 | R |
| 26. | Guy Hecker (28) | 6.8750 | 1884 | R |
| 27. | Tommy Bond (20) | 6.7692 | 1876 | R |
| 28. | Hugh Daily (36) | 6.7083 | 1884 | R |
| 29. | Monte Ward+ (19) | 6.6389 | 1879 | R |
| 30. | John Murphy (26) | 6.6364 | 1884 | |
| 31. | Guy Hecker (26) | 6.6000 | 1882 | R |
| 32. | Randy Johnson (40) | 6.5909 | 2004 | L |
| 33. | Bobby Mathews (31) | 6.5484 | 1883 | R |
| 34. | Curt Schilling (39) | 6.5357 | 2006 | R |
| 35. | Tommy Bond (23) | 6.4583 | 1879 | R |
| 36. | Greg Maddux (35) | 6.4074 | 2001 | R |
| 37. | Walter Johnson+ (25) | 6.3947 | 1913 | R |
| 38. | Roy Halladay (26) | 6.3750 | 2003 | R |
| 39. | Roy Halladay (34) | 6.2857 | 2011 | R |
| 40. | Peek-A-Boo Veach (22) | 6.2000 | 1884 | |
| 41. | Juan Marichal+ (28) | 6.1667 | 1966 | R |
| Christy Mathewson+ (27) | 6.1667 | 1908 | R | |
| 43. | Dennis Eckersley+ (30) | 6.1579 | 1985 | R |
| 44. | Greg Maddux (30) | 6.1429 | 1996 | R |
| 45. | Curt Schilling (36) | 6.0625 | 2003 | R |
| 46. | Pedro Martinez (30) | 5.9750 | 2002 | R |
| 47. | Roy Halladay (32) | 5.9429 | 2009 | R |
| 48. | Ed Morris (21) | 5.9216 | 1884 | L |
| 49. | Dan Haren (28) | 5.8684 | 2009 | R |
| 50. | Pud Galvin+ (27) | 5.8571 | 1884 | R |
| Rank | Player (age that year) | Strikeouts / Base On Balls | Year | Throws |
| 51. | Bobby Mathews (32) | 5.8367 | 1884 | R |
| 52. | Dan Haren (30) | 5.8182 | 2011 | R |
| 53. | Curt Schilling (37) | 5.8000 | 2004 | R |
| 54. | Cliff Lee (32) | 5.6667 | 2011 | L |
| Jon Lieber (34) | 5.6667 | 2004 | R | |
| 56. | CC Sabathia (26) | 5.6486 | 2007 | L |
| 57. | Old Hoss Radbourn+ (28) | 5.6250 | 1883 | R |
| 58. | David Wells (35) | 5.6207 | 1998 | L |
| 59. | Cy Young+ (39) | 5.6000 | 1906 | R |
| 60. | Pud Galvin+ (26) | 5.5800 | 1883 | R |
| 61. | Tommy Bond (22) | 5.5152 | 1878 | R |
| 62. | Brad Radke (31) | 5.5000 | 2004 | R |
| Curt Schilling (30) | 5.5000 | 1997 | R | |
| 64. | Charlie Buffinton (23) | 5.4868 | 1884 | R |
| 65. | Bob Black (21) | 5.4706 | 1884 | R |
| 66. | Greg Swindell (26) | 5.4516 | 1991 | L |
| 67. | Javier Vazquez (32) | 5.4091 | 2009 | R |
| 68. | Jim Whitney (27) | 5.4054 | 1885 | R |
| 69. | Sandy Koufax+ (29) | 5.3803 | 1965 | L |
| 70. | Jim Merritt (23) | 5.3667 | 1967 | L |
| 71. | David Wells (37) | 5.3548 | 2000 | L |
| 72. | Shane Reynolds (31) | 5.3243 | 1999 | R |
| 73. | Johan Santana (26) | 5.2889 | 2005 | L |
| 74. | Roy Halladay (31) | 5.2821 | 2008 | R |
| 75. | Jose Lima (25) | 5.2813 | 1998 | R |
| 76. | Sandy Koufax+ (27) | 5.2759 | 1963 | L |
| Rick Reed (33) | 5.2759 | 1998 | R | |
| 78. | Brad Radke (28) | 5.2692 | 2001 | R |
| 79. | Terry Larkin (22) | 5.2581 | 1878 | R |
| 80. | Kevin Brown (33) | 5.2449 | 1998 | R |
| 81. | Randy Johnson (37) | 5.2394 | 2001 | L |
| 82. | Shane Reynolds (26) | 5.2381 | 1994 | R |
| 83. | Juan Marichal+ (27) | 5.2174 | 1965 | R |
| 84. | Johan Santana (27) | 5.2128 | 2006 | L |
| 85. | Randy Johnson (35) | 5.2000 | 1999 | L |
| 86. | Dan Haren (27) | 5.1500 | 2008 | R |
| 87. | George Bradley (26) | 5.1154 | 1879 | R |
| 88. | James Shields (25) | 5.1111 | 2007 | R |
| Monte Ward+ (20) | 5.1111 | 1880 | R | |
| 90. | Mike Mussina (32) | 5.0952 | 2001 | R |
| David Wells (42) | 5.0952 | 2005 | L | |
| 92. | Brad Radke (32) | 5.0870 | 2005 | R |
| 93. | Josh Beckett (28) | 5.0588 | 2008 | R |
| 94. | Bill Sweeney (26) | 5.0541 | 1884 | R |
| 95. | David Wells (40) | 5.0500 | 2003 | L |
| David Wells (41) | 5.0500 | 2004 | L | |
| 97. | Greg Maddux (28) | 5.0323 | 1994 | R |
| 98. | Gaylord Perry+ (27) | 5.0250 | 1966 | R |
| 99. | Jim Kaat (28) | 5.0238 | 1967 | L |
| 100. | John Smoltz (29) | 5.0182 | 1996 | R |
| Rank | Player (age that year) | Strikeouts / Base On Balls | Year | Throws |
| 101. | Bobby Mathews (33) | 5.0175 | 1885 | R |
| 102. | Fred Goldsmith (24) | 5.0000 | 1880 | R |
| Fergie Jenkins+ (31) | 5.0000 | 1974 | R | |
| Cliff Lee (29) | 5.0000 | 2008 | L | |
| 105. | Brandon McCarthy (27) | 4.9200 | 2011 | R |
| 106. | Curt Schilling (31) | 4.9180 | 1998 | R |
| 107. | Denny Driscoll (26) | 4.9167 | 1882 | L |
| 108. | Mike Mussina (37) | 4.9143 | 2006 | R |
| 109. | Johan Santana (25) | 4.9074 | 2004 | L |
| 110. | Mark Prior (22) | 4.9000 | 2003 | R |
| 111. | Joe Blanton (31) | 4.8824 | 2012 | R |
| 112. | Mike Mussina (34) | 4.8750 | 2003 | R |
| 113. | Josh Beckett (27) | 4.8500 | 2007 | R |
| Bob Tewksbury (32) | 4.8500 | 1993 | R | |
| 115. | Mike Mussina (39) | 4.8387 | 2008 | R |
| 116. | Cherokee Fisher (31) | 4.8333 | 1876 | R |
| 117. | Lady Baldwin (26) | 4.8214 | 1885 | L |
| 118. | Kevin Brown (31) | 4.8182 | 1996 | R |
| 119. | Ed Walsh+ (27) | 4.8036 | 1908 | R |
| 120. | LaMarr Hoyt (28) | 4.7742 | 1983 | R |
| 121. | Jim Bunning+ (32) | 4.7609 | 1964 | R |
| 122. | Jack Lynch (26) | 4.7600 | 1883 | R |
| 123. | Cy Young+ (36) | 4.7568 | 1903 | R |
| 124. | Zack Greinke (25) | 4.7451 | 2009 | R |
| 125. | Juan Marichal+ (30) | 4.7391 | 1968 | R |
| 126. | Tom Seaver+ (26) | 4.7377 | 1971 | R |
| 127. | Terry Larkin (23) | 4.7333 | 1879 | R |
| 128. | Shane Reynolds (27) | 4.7297 | 1995 | R |
| 129. | Javier Vazquez (24) | 4.7273 | 2001 | R |
| 130. | Tommy Bond (21) | 4.7222 | 1877 | R |
| 131. | Randy Johnson (38) | 4.7042 | 2002 | L |
| Tim Keefe+ (27) | 4.7042 | 1884 | R | |
| 133. | Roger Clemens (25) | 4.6935 | 1988 | R |
| 134. | Deacon Phillippe (30) | 4.6923 | 1902 | R |
| 135. | Babe Adams (38) | 4.6667 | 1920 | R |
| 136. | Rick Reed (37) | 4.6538 | 2002 | R |
| 137. | Shane Reynolds (28) | 4.6364 | 1996 | R |
| 138. | John Burkett (32) | 4.6333 | 1997 | R |
| 139. | Kevin Brown (35) | 4.5957 | 2000 | R |
| 140. | Clayton Kershaw (23) | 4.5926 | 2011 | L |
| 141. | Jim Bunning+ (34) | 4.5818 | 1966 | R |
| 142. | Rick Reed (36) | 4.5806 | 2001 | R |
| 143. | Greg Maddux (38) | 4.5758 | 2004 | R |
| 144. | Al Atkinson (23) | 4.5741 | 1884 | R |
| 145. | Fergie Jenkins+ (27) | 4.5667 | 1970 | R |
| 146. | Randy Johnson (36) | 4.5658 | 2000 | L |
| 147. | Mike Mussina (31) | 4.5652 | 2000 | R |
| 148. | Ervin Santana (25) | 4.5532 | 2008 | R |
| 149. | Pedro Martinez (25) | 4.5522 | 1997 | R |
| 150. | Bob Tewksbury (31) | 4.5500 | 1992 | R |
| Rank | Player (age that year) | Strikeouts / Base On Balls | Year | Throws |
| 151. | Greg Maddux (32) | 4.5333 | 1998 | R |
| 152. | Greg Maddux (34) | 4.5238 | 2000 | R |
| Sam Weaver (22) | 4.5238 | 1878 | R | |
| 154. | Randy Johnson (31) | 4.5231 | 1995 | L |
| 155. | Jason Schmidt (30) | 4.5217 | 2003 | R |
| 156. | Johan Santana (28) | 4.5192 | 2007 | L |
| 157. | Old Hoss Radbourn+ (29) | 4.5000 | 1884 | R |
| 158. | Randy Johnson (41) | 4.4894 | 2005 | L |
| 159. | Bret Saberhagen (25) | 4.4884 | 1989 | R |
| 160. | Scott Sanderson (34) | 4.4828 | 1991 | R |
| 161. | CC Sabathia (31) | 4.4773 | 2012 | L |
| 162. | Zack Greinke (27) | 4.4667 | 2011 | R |
| Bill Wise (23) | 4.4667 | 1884 | ||
| 164. | Denny McLain (24) | 4.4444 | 1968 | R |
| 165. | Ricky Nolasco (26) | 4.4318 | 2009 | R |
| 166. | Christy Mathewson+ (32) | 4.4286 | 1913 | R |
| Ricky Nolasco (25) | 4.4286 | 2008 | R | |
| 168. | Pedro Martinez (33) | 4.4255 | 2005 | R |
| 169. | Cole Hamels (27) | 4.4091 | 2011 | L |
| 170. | Don Drysdale+ (26) | 4.4035 | 1963 | R |
| 171. | Erik Hanson (29) | 4.3913 | 1994 | R |
| 172. | Jim Whitney (24) | 4.3902 | 1882 | R |
| 173. | Pud Galvin+ (22) | 4.3871 | 1879 | R |
| 174. | Justin Verlander (28) | 4.3860 | 2011 | R |
| 175. | Pedro Martinez (31) | 4.3830 | 2003 | R |
| 176. | Jimmy Key (28) | 4.3704 | 1989 | L |
| 177. | Dave Bush (26) | 4.3684 | 2006 | R |
| Roy Oswalt (28) | 4.3684 | 2006 | R | |
| 179. | Addie Joss+ (28) | 4.3333 | 1908 | R |
| Joe Nuxhall (34) | 4.3333 | 1963 | L | |
| 181. | Jim Bunning+ (33) | 4.3226 | 1965 | R |
| Bob Gibson+ (32) | 4.3226 | 1968 | R | |
| 183. | Jake Peavy (24) | 4.3200 | 2005 | R |
| 184. | Jered Weaver (27) | 4.3148 | 2010 | R |
| 185. | Roger Clemens (34) | 4.2941 | 1997 | R |
| 186. | Brad Radke (30) | 4.2857 | 2003 | R |
| 187. | Pretzels Getzien (20) | 4.2800 | 1884 | R |
| 188. | Chris Carpenter (31) | 4.2791 | 2006 | R |
| 189. | Tom Seaver+ (23) | 4.2708 | 1968 | R |
| 190. | Cy Young+ (34) | 4.2703 | 1901 | R |
| 191. | Justin Verlander (26) | 4.2698 | 2009 | R |
| 192. | Mike Mussina (29) | 4.2683 | 1998 | R |
| 193. | Javier Vazquez (30) | 4.2600 | 2007 | R |
| 194. | R.A. Dickey (37) | 4.2593 | 2012 | R |
| 195. | CC Sabathia (27) | 4.2542 | 2008 | L |
| 196. | Jose Lima (26) | 4.2500 | 1999 | R |
| Mike Scott (31) | 4.2500 | 1986 | R | |
| 198. | Deacon Phillippe (31) | 4.2414 | 1903 | R |
| 199. | Josh Tomlin (26) | 4.2381 | 2011 | R |
| 200. | Ed Walsh+ (29) | 4.2295 | 1910 | R |
| Rank | Player (age that year) | Strikeouts / Base On Balls | Year | Throws |
| 201. | Javier Vazquez (26) | 4.2281 | 2003 | R |
| 202. | Jack Lynch (28) | 4.2143 | 1885 | R |
| 203. | Cliff Lee (30) | 4.2093 | 2009 | L |
| 204. | Sandy Koufax+ (28) | 4.2075 | 1964 | L |
| 205. | Ted Lilly (33) | 4.1944 | 2009 | L |
| 206. | Aaron Harang (29) | 4.1923 | 2007 | R |
| 207. | John Smoltz (40) | 4.1915 | 2007 | R |
| 208. | Gary Nolan (28) | 4.1852 | 1976 | R |
| 209. | Chris Carpenter (30) | 4.1765 | 2005 | R |
| 210. | Javier Vazquez (28) | 4.1739 | 2005 | R |
| 211. | Andy Pettitte (33) | 4.1707 | 2005 | L |
| 212. | Jon Lieber (36) | 4.1667 | 2006 | R |
| 213. | Greg Maddux (41) | 4.1600 | 2007 | R |
| 214. | Bret Saberhagen (21) | 4.1579 | 1985 | R |
| 215. | Cole Hamels (28) | 4.1538 | 2012 | L |
| 216. | Madison Bumgarner (21) | 4.1522 | 2011 | L |
| Sonny Siebert (28) | 4.1522 | 1965 | R | |
| 218. | LaMarr Hoyt (30) | 4.1500 | 1985 | R |
| 219. | Bill Monbouquette (26) | 4.1429 | 1963 | R |
| 220. | Bob Barr (27) | 4.1400 | 1884 | R |
| 221. | Christy Mathewson+ (28) | 4.1389 | 1909 | R |
| 222. | Zane Smith (30) | 4.1379 | 1991 | L |
| 223. | Dupee Shaw (25) | 4.1376 | 1884 | L |
| 224. | Stump Wiedman (21) | 4.1282 | 1882 | R |
| 225. | Pedro Ramos (28) | 4.1220 | 1963 | R |
| 226. | Walter Johnson+ (22) | 4.1184 | 1910 | R |
| 227. | Sandy Koufax+ (30) | 4.1169 | 1966 | L |
| 228. | Cole Hamels (23) | 4.1163 | 2007 | L |
| 229. | Bill Hands (28) | 4.1111 | 1968 | R |
| 230. | Charlie Geggus (22) | 4.1053 | 1884 | |
| Abner Powell (23) | 4.1053 | 1884 | R | |
| 232. | Bob Bruce (31) | 4.0909 | 1964 | R |
| Steve Woodard (23) | 4.0909 | 1998 | R | |
| 234. | John Clarkson+ (22) | 4.0800 | 1884 | R |
| 235. | Odalis Perez (24) | 4.0789 | 2002 | L |
| 236. | Bob Friend (29) | 4.0667 | 1960 | R |
| 237. | Juan Marichal+ (25) | 4.0656 | 1963 | R |
| 238. | Cy Young+ (41) | 4.0541 | 1908 | R |
| 239. | Pud Galvin+ (25) | 4.0500 | 1882 | R |
| 240. | Jon Lieber (29) | 4.0435 | 1999 | R |
| 241. | Mike Mussina (28) | 4.0370 | 1997 | R |
| 242. | Jeff Fassero (33) | 4.0364 | 1996 | L |
| 243. | Eric Milton (26) | 4.0333 | 2002 | L |
| 244. | Bob Ojeda (30) | 4.0303 | 1988 | L |
| 245. | Turk Farrell (29) | 4.0286 | 1963 | R |
| Jumbo McGinnis (30) | 4.0286 | 1884 | ||
| 247. | Jimmy Key (32) | 4.0233 | 1993 | L |
| 248. | Don Sutton+ (21) | 4.0192 | 1966 | R |
| 249. | Babe Adams (37) | 4.0000 | 1919 | R |
| Chris Carpenter (29) | 4.0000 | 2004 | R | |
| Rank | Player (age that year) | Strikeouts / Base On Balls | Year | Throws |
| Ed Dugan (20) | 4.0000 | 1884 | R | |
| Pud Galvin+ (23) | 4.0000 | 1880 | R | |
| Ron Guidry (30) | 4.0000 | 1981 | L | |
| Dan Haren (29) | 4.0000 | 2010 | R | |
| Fergie Jenkins+ (25) | 4.0000 | 1968 | R | |
| Andy Pettitte (29) | 4.0000 | 2001 | L | |
| James Shields (26) | 4.0000 | 2008 | R | |
| Greg Swindell (23) | 4.0000 | 1988 | L | |
| Jesse Tannehill (27) | 4.0000 | 1902 | L | |
| 260. | Walter Johnson+ (24) | 3.9868 | 1912 | R |
| 261. | Justin Verlander (29) | 3.9833 | 2012 | R |
| 262. | Felix Hernandez (26) | 3.9821 | 2012 | R |
| 263. | Atlee Hammaker (25) | 3.9688 | 1983 | L |
| 264. | Fritz Peterson (26) | 3.9655 | 1968 | L |
| 265. | Juan Marichal+ (26) | 3.9615 | 1964 | R |
| 266. | Jake Peavy (31) | 3.9592 | 2012 | R |
| 267. | Brian Anderson (26) | 3.9583 | 1998 | L |
| 268. | Juan Marichal+ (29) | 3.9524 | 1967 | R |
| 269. | Doug Fister (27) | 3.9459 | 2011 | R |
| 270. | Shane Reynolds (30) | 3.9434 | 1998 | R |
| 271. | Christy Mathewson+ (31) | 3.9412 | 1912 | R |
| Old Hoss Radbourn+ (27) | 3.9412 | 1882 | R | |
| 273. | Don Drysdale+ (29) | 3.9333 | 1966 | R |
| 274. | Randy Johnson (44) | 3.9318 | 2008 | L |
| John Smoltz (31) | 3.9318 | 1998 | R | |
| 276. | Robin Roberts+ (29) | 3.9250 | 1956 | R |
| 277. | Tom Seaver+ (28) | 3.9219 | 1973 | R |
| 278. | Robin Roberts+ (32) | 3.9143 | 1959 | R |
| 279. | John Candelaria (30) | 3.9118 | 1984 | L |
| 280. | Dan Haren (25) | 3.9111 | 2006 | R |
| 281. | CC Sabathia (25) | 3.9091 | 2006 | L |
| 282. | Cole Hamels (25) | 3.9070 | 2009 | L |
| 283. | Monte Ward+ (23) | 3.9032 | 1883 | R |
| 284. | John Smoltz (32) | 3.9000 | 1999 | R |
| 285. | Madison Bumgarner (22) | 3.8980 | 2012 | L |
| 286. | Wade Miley (25) | 3.8919 | 2012 | L |
| 287. | Joel Pineiro (30) | 3.8889 | 2009 | R |
| 288. | Jose Rijo (27) | 3.8864 | 1992 | R |
| 289. | Dwight Gooden (20) | 3.8841 | 1985 | R |
| 290. | Roy Halladay (29) | 3.8824 | 2006 | R |
| 291. | Erik Bedard (28) | 3.8772 | 2007 | L |
| 292. | Josh Johnson (26) | 3.8750 | 2010 | R |
| Bill McGunnigle (24) | 3.8750 | 1879 | R | |
| 294. | Roger Nelson (28) | 3.8710 | 1972 | R |
| 295. | Roger Clemens (27) | 3.8704 | 1990 | R |
| Guy Hecker (29) | 3.8704 | 1885 | R | |
| 297. | Ken Johnson (29) | 3.8696 | 1962 | R |
| 298. | Bob Caruthers (20) | 3.8667 | 1884 | R |
| 299. | Josh Towers (28) | 3.8621 | 2005 | R |
| 300. | Mario Soto (25) | 3.8592 | 1982 | R |
| Rank | Player (age that year) | Strikeouts / Base On Balls | Year | Throws |
| 301. | Aaron Harang (28) | 3.8571 | 2006 | R |
| 302. | Jim McCormick (27) | 3.8539 | 1884 | R |
| 303. | Bert Blyleven+ (22) | 3.8507 | 1973 | R |
| 304. | Max Scherzer (27) | 3.8500 | 2012 | R |
| 305. | Fergie Jenkins+ (26) | 3.8451 | 1969 | R |
| 306. | James Shields (30) | 3.8448 | 2012 | R |
| 307. | Tim Lincecum (25) | 3.8382 | 2009 | R |
| 308. | Shaun Marcum (28) | 3.8372 | 2010 | R |
| 309. | John Smoltz (39) | 3.8364 | 2006 | R |
| 310. | Rube Waddell+ (27) | 3.8352 | 1904 | L |
| 311. | Roy Oswalt (27) | 3.8333 | 2005 | R |
| 312. | Fergie Jenkins+ (35) | 3.8293 | 1978 | R |
| 313. | Ray Prim (38) | 3.8261 | 1945 | L |
| 314. | Randy Johnson (34) | 3.8256 | 1998 | L |
| 315. | John Smoltz (30) | 3.8254 | 1997 | R |
| 316. | Bob Bruce (32) | 3.8158 | 1965 | R |
| 317. | Bryn Smith (32) | 3.8125 | 1988 | R |
| 318. | Tommy Milone (25) | 3.8056 | 2012 | L |
| 319. | Adam Wainwright (28) | 3.8036 | 2010 | R |
| 320. | Curry Foley (23) | 3.8000 | 1879 | L |
| 321. | Bert Blyleven+ (20) | 3.7966 | 1971 | R |
| 322. | Juan Marichal+ (31) | 3.7963 | 1969 | R |
| 323. | Mike Mussina (33) | 3.7917 | 2002 | R |
| 324. | Chris Carpenter (34) | 3.7895 | 2009 | R |
| Sandy Koufax+ (26) | 3.7895 | 1962 | L | |
| 326. | Greg Maddux (27) | 3.7885 | 1993 | R |
| 327. | Matt Cain (27) | 3.7843 | 2012 | R |
| 328. | Dwight Gooden (19) | 3.7808 | 1984 | R |
| 329. | Mat Latos (22) | 3.7800 | 2010 | R |
| 330. | Randy Johnson (33) | 3.7792 | 1997 | L |
| 331. | Greg Maddux (39) | 3.7778 | 2005 | R |
| 332. | Ted Lilly (34) | 3.7727 | 2010 | L |
| 333. | CC Sabathia (30) | 3.7705 | 2011 | L |
| 334. | Carl Pavano (33) | 3.7692 | 2009 | R |
| 335. | Pete Alexander+ (28) | 3.7656 | 1915 | R |
| 336. | Chris Sale (23) | 3.7647 | 2012 | L |
| 337. | Kyle Lohse (33) | 3.7632 | 2012 | R |
| Don Newcombe (29) | 3.7632 | 1955 | R | |
| 339. | Jamie Moyer (35) | 3.7619 | 1998 | L |
| 340. | Greg Maddux (37) | 3.7576 | 2003 | R |
| 341. | Doyle Alexander (35) | 3.7568 | 1986 | R |
| 342. | Will White (23) | 3.7556 | 1878 | R |
| 343. | Pedro Martinez (26) | 3.7463 | 1998 | R |
| 344. | Kevin Brown (34) | 3.7458 | 1999 | R |
| 345. | Pretzels Getzien (24) | 3.7407 | 1888 | R |
| 346. | Dan Haren (31) | 3.7368 | 2012 | R |
| 347. | Curt Schilling (33) | 3.7333 | 2000 | R |
| 348. | Jim Kaat (27) | 3.7273 | 1966 | L |
| Bobby Mitchell (21) | 3.7273 | 1877 | L | |
| 350. | Mark Buehrle (26) | 3.7250 | 2005 | L |
| Rank | Player (age that year) | Strikeouts / Base On Balls | Year | Throws |
| Kevin Tapani (37) | 3.7250 | 2001 | R | |
| 352. | Joey Jay (28) | 3.7222 | 1964 | R |
| Tim Keefe+ (31) | 3.7222 | 1888 | R | |
| 354. | Pedro Martinez (32) | 3.7213 | 2004 | R |
| 355. | Dean Chance (27) | 3.7143 | 1968 | R |
| 356. | Christy Mathewson+ (30) | 3.7105 | 1911 | R |
| Doc White (28) | 3.7105 | 1907 | L | |
| 358. | Roger Clemens (28) | 3.7077 | 1991 | R |
| 359. | Bert Blyleven+ (35) | 3.7069 | 1986 | R |
| 360. | Andy Benes (26) | 3.7059 | 1994 | R |
| 361. | Zack Greinke (28) | 3.7037 | 2012 | R |
| Don Newcombe (33) | 3.7037 | 1959 | R | |
| 363. | Chris Capuano (27) | 3.7021 | 2006 | L |
| 364. | Cole Hamels (24) | 3.6981 | 2008 | L |
| 365. | Esteban Loaiza (31) | 3.6964 | 2003 | R |
| 366. | Turk Farrell (28) | 3.6909 | 1962 | R |
| 367. | Milt Pappas (29) | 3.6875 | 1968 | R |
| 368. | Charlie Buffinton (22) | 3.6863 | 1883 | R |
| 369. | Bronson Arroyo (35) | 3.6857 | 2012 | R |
| 370. | Frank Tanana (21) | 3.6849 | 1975 | L |
| 371. | Ron Guidry (35) | 3.6842 | 1986 | L |
| 372. | Dizzy Dean+ (26) | 3.6792 | 1936 | R |
| 373. | Greg Maddux (33) | 3.6757 | 1999 | R |
| 374. | Bob Gibson+ (31) | 3.6750 | 1967 | R |
| 375. | Dave McNally (25) | 3.6727 | 1968 | L |
| 376. | Vern Law (36) | 3.6667 | 1966 | R |
| Ben Sanders (23) | 3.6667 | 1888 | R | |
| James Shields (28) | 3.6667 | 2010 | R | |
| 379. | Jose Rijo (28) | 3.6613 | 1993 | R |
| 380. | Paul Derringer (32) | 3.6571 | 1939 | R |
| 381. | Pete Meegan (21) | 3.6552 | 1884 | |
| 382. | Javier Vazquez (25) | 3.6531 | 2002 | R |
| 383. | Ralph Terry (29) | 3.6522 | 1965 | R |
| 384. | Tony Mullane (25) | 3.6517 | 1884 | |
| 385. | Bartolo Colon (32) | 3.6512 | 2005 | R |
| Ben Sheets (24) | 3.6512 | 2003 | R | |
| Jeff Weaver (28) | 3.6512 | 2005 | R | |
| 388. | Harry Salisbury (27) | 3.6486 | 1882 | |
| 389. | Rick Reed (32) | 3.6452 | 1997 | R |
| 390. | Paul Byrd (34) | 3.6429 | 2005 | R |
| Atlee Hammaker (24) | 3.6429 | 1982 | L | |
| 392. | Curt Schilling (29) | 3.6400 | 1996 | R |
| 393. | John Clarkson+ (24) | 3.6395 | 1886 | R |
| 394. | Dizzy Dean+ (27) | 3.6364 | 1937 | R |
| Eric Milton (24) | 3.6364 | 2000 | L | |
| Sam Weaver (28) | 3.6364 | 1884 | R | |
| 397. | Clayton Kershaw (24) | 3.6349 | 2012 | L |
| 398. | Jon Lieber (35) | 3.6341 | 2005 | R |
| 399. | Daisy Davis (25) | 3.6279 | 1884 | R |
| Glendon Rusch (26) | 3.6279 | 2001 | L | |
| Rank | Player (age that year) | Strikeouts / Base On Balls | Year | Throws |
| 401. | John Burkett (28) | 3.6250 | 1993 | R |
| Walter Johnson+ (27) | 3.6250 | 1915 | R | |
| Brad Radke (24) | 3.6250 | 1997 | R | |
| 404. | Josh Beckett (29) | 3.6182 | 2009 | R |
| 405. | Luis Tiant (27) | 3.6164 | 1968 | R |
| 406. | Jon Lieber (31) | 3.6098 | 2001 | R |
| 407. | Gaylord Perry+ (25) | 3.6047 | 1964 | R |
| 408. | Chris Bosio (26) | 3.6042 | 1989 | R |
| 409. | Ian Kennedy (26) | 3.6000 | 2011 | R |
| Andy Pettitte (31) | 3.6000 | 2003 | L | |
| 411. | John Candelaria (28) | 3.5946 | 1982 | L |
| 412. | Bob Tewksbury (33) | 3.5909 | 1994 | R |
| 413. | Robin Roberts+ (33) | 3.5882 | 1960 | R |
| 414. | Phil Hughes (26) | 3.5870 | 2012 | R |
| 415. | Don Sutton+ (36) | 3.5862 | 1981 | R |
| 416. | Mike Scott (33) | 3.5849 | 1988 | R |
| 417. | David Cone (27) | 3.5846 | 1990 | R |
| 418. | Chief Bender+ (25) | 3.5778 | 1909 | R |
| Gus Krock (22) | 3.5778 | 1888 | R | |
| 420. | Frank Tanana (22) | 3.5753 | 1976 | L |
| 421. | Frank Viola (28) | 3.5741 | 1988 | L |
| 422. | Pete Alexander+ (30) | 3.5714 | 1917 | R |
| Don Sutton+ (28) | 3.5714 | 1973 | R | |
| 424. | Glendon Rusch (25) | 3.5682 | 2000 | L |
| 425. | Steve Carlton+ (27) | 3.5632 | 1972 | L |
| 426. | Brandon Webb (27) | 3.5600 | 2006 | R |
| 427. | Rick Reed (35) | 3.5588 | 2000 | R |
| 428. | Jordan Zimmermann (26) | 3.5581 | 2012 | R |
| 429. | Danny Darwin (40) | 3.5556 | 1996 | R |
| Jon Lieber (30) | 3.5556 | 2000 | R | |
| Pete Schourek (26) | 3.5556 | 1995 | L | |
| 432. | Dick Burns (20) | 3.5532 | 1884 | L |
| 433. | Rube Waddell+ (26) | 3.5529 | 1903 | L |
| 434. | Roger Clemens (23) | 3.5522 | 1986 | R |
| 435. | Chris Short (26) | 3.5490 | 1964 | L |
| 436. | Rheal Cormier (25) | 3.5455 | 1992 | L |
| 437. | David Cone (35) | 3.5424 | 1998 | R |
| 438. | Ed Walsh+ (30) | 3.5417 | 1911 | R |
| 439. | Adam Wainwright (30) | 3.5385 | 2012 | R |
| 440. | Dennis Eckersley+ (22) | 3.5370 | 1977 | R |
| 441. | Jered Weaver (28) | 3.5357 | 2011 | R |
| 442. | Jake Peavy (26) | 3.5294 | 2007 | R |
| 443. | Don Sutton+ (26) | 3.5273 | 1971 | R |
| 444. | Scott McGregor (25) | 3.5217 | 1979 | L |
| 445. | Danny Darwin (34) | 3.5161 | 1990 | R |
| 446. | Jon Lester (25) | 3.5156 | 2009 | L |
| 447. | Jesse Tannehill (29) | 3.5152 | 1904 | L |
| 448. | Roy Oswalt (30) | 3.5106 | 2008 | R |
| 449. | Denny Neagle (28) | 3.5102 | 1997 | L |
| 450. | Roy Oswalt (32) | 3.5091 | 2010 | R |
| Rank | Player (age that year) | Strikeouts / Base On Balls | Year | Throws |
| 451. | Yovani Gallardo (25) | 3.5085 | 2011 | R |
| 452. | Joe Blanton (26) | 3.5000 | 2007 | R |
| Dick Rudolph (28) | 3.5000 | 1916 | R | |
| 454. | Camilo Pascual (28) | 3.4915 | 1962 | R |
| 455. | Dan Haren (26) | 3.4909 | 2007 | R |
| 456. | John Candelaria (29) | 3.4889 | 1983 | L |
| 457. | Fritz Peterson (27) | 3.4884 | 1969 | L |
| 458. | Harvey Haddix (31) | 3.4872 | 1957 | L |
| 459. | Turk Farrell (31) | 3.4857 | 1965 | R |
| 460. | Don Drysdale+ (27) | 3.4853 | 1964 | R |
| 461. | Lefty Grove+ (30) | 3.4833 | 1930 | L |
| 462. | Jim Merritt (24) | 3.4808 | 1968 | L |
| 463. | Anibal Sanchez (28) | 3.4792 | 2012 | R |
| 464. | Christy Mathewson+ (33) | 3.4783 | 1914 | R |
| 465. | Jim Whitney (29) | 3.4762 | 1887 | R |
| 466. | Kevin Millwood (24) | 3.4746 | 1999 | R |
| David Price (26) | 3.4746 | 2012 | L | |
| 468. | Chris Carpenter (36) | 3.4727 | 2011 | R |
| 469. | Johnny Cueto (26) | 3.4694 | 2012 | R |
| 470. | Jake Peavy (25) | 3.4677 | 2006 | R |
| 471. | Jim McCormick (23) | 3.4667 | 1880 | R |
| David Wells (34) | 3.4667 | 1997 | L | |
| 473. | Jim Bunning+ (35) | 3.4658 | 1967 | R |
| 474. | Francisco Liriano (26) | 3.4655 | 2010 | L |
| 475. | Noodles Hahn (22) | 3.4638 | 1901 | L |
| 476. | Bobby Mathews (27) | 3.4615 | 1879 | R |
| Deacon Phillippe (34) | 3.4615 | 1906 | R | |
| James Shields (29) | 3.4615 | 2011 | R | |
| 479. | David Price (25) | 3.4603 | 2011 | L |
| 480. | Cole Hamels (26) | 3.4590 | 2010 | L |
| 481. | Curt Schilling (32) | 3.4545 | 1999 | R |
| 482. | Doug Bird (26) | 3.4516 | 1976 | R |
| 483. | Jon Lieber (28) | 3.4500 | 1998 | R |
| 484. | John Tudor (31) | 3.4490 | 1985 | L |
| 485. | Bret Saberhagen (34) | 3.4483 | 1998 | R |
| 486. | Ron Guidry (27) | 3.4444 | 1978 | L |
| 487. | John Lackey (28) | 3.4423 | 2007 | R |
| 488. | Scott Baker (28) | 3.4419 | 2010 | R |
| 489. | Gil Heredia (33) | 3.4412 | 1999 | R |
| 490. | Jim Devlin (28) | 3.4390 | 1877 | R |
| 491. | Matt Morris (26) | 3.4259 | 2001 | R |
| 492. | Carl Hubbell+ (29) | 3.4250 | 1932 | L |
| 493. | Vida Blue (21) | 3.4205 | 1971 | L |
| 494. | Don Drysdale+ (23) | 3.4167 | 1960 | R |
| 495. | Monte Ward+ (18) | 3.4118 | 1878 | R |
| Will White (24) | 3.4118 | 1879 | R | |
| 497. | Rudy May (35) | 3.4103 | 1980 | L |
| Milt Pappas (27) | 3.4103 | 1966 | R | |
| 499. | Tom Seaver+ (25) | 3.4096 | 1970 | R |
| 500. | Ron Guidry (34) | 3.4048 | 1985 | L |
Note that seasons prior to 1876 are not included in single-season marks, but are included in career marks.