+ - Indicates Hall of Famer. Bold indicates active player.
Statistic Description: SO/BB For recent years, leaders need 1 IP per team game played
Minimum of 1000 IP, 3000 PA, 500 games (fielding), 200 stolen base attempts (catchers) or 80 stolen base attempts (baserunners only since 1951) or 100 decisions for career and active leaderboards for rate statistics.
| Rank | Player (yrs, age) | Strikeouts / Base On Balls | Throws |
|---|---|---|---|
| 1. | Mariano Rivera (19, 43) | 4.0609 | R |
| 2. | Dan Haren (11, 32) | 4.0223 | R |
| 3. | James Shields (8, 31) | 3.7155 | R |
| 4. | Cole Hamels (8, 29) | 3.7065 | L |
| 5. | Roy Halladay (16, 36) | 3.6667 | R |
| 6. | Cliff Lee (12, 34) | 3.6605 | L |
| 7. | Zack Greinke (10, 29) | 3.5170 | R |
| 8. | Ricky Nolasco (8, 30) | 3.5073 | R |
| 9. | Johan Santana (12, 34) | 3.5062 | L |
| 10. | Jake Peavy (12, 32) | 3.2193 | R |
| 11. | Adam Wainwright (8, 31) | 3.1824 | R |
| 12. | Felix Hernandez (9, 27) | 3.1687 | R |
| 13. | Jered Weaver (8, 30) | 3.1337 | R |
| 14. | Justin Verlander (9, 30) | 3.1018 | R |
| 15. | Josh Beckett (13, 33) | 3.0407 | R |
| 16. | Clayton Kershaw (6, 25) | 2.9136 | L |
| 17. | CC Sabathia (13, 32) | 2.8954 | L |
| 18. | Tim Lincecum (7, 29) | 2.7794 | R |
| 19. | Chris Carpenter (15, 38) | 2.7065 | R |
| 20. | Aaron Harang (12, 35) | 2.6793 | R |
| 21. | Chris Capuano (9, 34) | 2.6390 | L |
| 22. | Dave Bush (9, 33) | 2.5946 | R |
| 23. | John Lackey (11, 34) | 2.5945 | R |
| 24. | Joe Blanton (10, 32) | 2.5908 | R |
| 25. | Ted Lilly (15, 37) | 2.5527 | L |
| 26. | Mark Buehrle (14, 34) | 2.5096 | L |
| 27. | Ervin Santana (9, 30) | 2.5021 | R |
| 28. | Jon Lester (8, 29) | 2.4821 | L |
| 29. | Brett Myers (12, 32) | 2.4802 | R |
| 30. | Matt Garza (8, 29) | 2.4576 | R |
| 31. | Matt Cain (9, 28) | 2.4567 | R |
| 32. | Erik Bedard (10, 34) | 2.4279 | L |
| 33. | Wandy Rodriguez (9, 34) | 2.4230 | L |
| 34. | Bartolo Colon (16, 40) | 2.3977 | R |
| 35. | Andy Pettitte (18, 41) | 2.3637 | L |
| 36. | Bronson Arroyo (14, 36) | 2.3222 | R |
| 37. | Gavin Floyd (10, 30) | 2.3154 | R |
| 38. | Jeremy Bonderman (8, 30) | 2.2995 | R |
| 39. | Esteban Loaiza (14, 41) | 2.2881 | R |
| 40. | Freddy Garcia (15, 36) | 2.2712 | R |
| 41. | A.J. Burnett (15, 36) | 2.2503 | R |
| 42. | Ismael Valdez (12, 39) | 2.2428 | R |
| 43. | Tim Hudson (15, 37) | 2.2364 | R |
| 44. | R.A. Dickey (11, 38) | 2.2310 | R |
| 45. | Kyle Lohse (13, 34) | 2.2174 | R |
| 46. | Jeff Francis (9, 32) | 2.2127 | L |
| 47. | Derek Lowe (17, 40) | 2.1688 | R |
| 48. | Kelvim Escobar (12, 37) | 2.1440 | R |
| 49. | Scott Kazmir (9, 29) | 2.1180 | L |
| 50. | Chad Billingsley (8, 28) | 2.1120 | R |
| Rank | Player (yrs, age) | Strikeouts / Base On Balls | Throws |
| 51. | Jose Contreras (11, 41) | 2.1043 | R |
| 52. | Bruce Chen (15, 36) | 2.0889 | L |
| 53. | Rodrigo Lopez (11, 37) | 2.0793 | R |
| 54. | LaTroy Hawkins (19, 40) | 2.0488 | R |
| 55. | Jeremy Guthrie (10, 34) | 2.0294 | R |
| 56. | Ubaldo Jimenez (8, 29) | 1.9903 | R |
| 57. | Paul Maholm (9, 31) | 1.9626 | L |
| 58. | Edwin Jackson (11, 29) | 1.9595 | R |
| 59. | Ryan Dempster (16, 36) | 1.9479 | R |
| 60. | Mark Hendrickson (10, 39) | 1.9304 | L |
| 61. | Zach Duke (9, 30) | 1.9241 | L |
| 62. | Kevin Correia (11, 32) | 1.8821 | R |
| 63. | Nate Robertson (9, 35) | 1.8452 | L |
| 64. | Joe Saunders (9, 32) | 1.8289 | L |
| 65. | Oliver Perez (11, 31) | 1.8117 | L |
| 66. | Ramon Ortiz (12, 40) | 1.7948 | R |
| 67. | Barry Zito (14, 35) | 1.7922 | L |
| 68. | Jake Westbrook (13, 35) | 1.7440 | R |
| 69. | Darren Oliver (20, 42) | 1.7300 | L |
| 70. | Jon Garland (13, 33) | 1.6084 | R |
| 71. | Jason Marquis (14, 34) | 1.5343 | R |
| 72. | Kip Wells (12, 36) | 1.5165 | R |
| 73. | Miguel Batista (18, 42) | 1.3904 | R |
| 74. | Aaron Cook (11, 34) | 1.3473 | R |
| 75. | Jamey Wright (18, 38) | 1.1581 | R |