+ - Indicates Hall of Famer. Bold indicates active player.
Statistic Description: SO/BB For recent years, leaders need 1 IP per team game played
Minimum of 1000 IP, 3000 PA, 500 games (fielding), 200 stolen base attempts (catchers) or 80 stolen base attempts (baserunners only since 1951) or 100 decisions for career and active leaderboards for rate statistics.
| Rank | Player (yrs, age) | Strikeouts / Base On Balls | Throws |
|---|---|---|---|
| 1. | Dan Haren (10, 31) | 4.0485 | R |
| 2. | Mariano Rivera (18, 42) | 4.0397 | R |
| 3. | Cole Hamels (7, 28) | 3.8007 | L |
| 4. | Roy Halladay (15, 35) | 3.7266 | R |
| 5. | James Shields (7, 30) | 3.6073 | R |
| 6. | Johan Santana (12, 33) | 3.5607 | L |
| 7. | Zack Greinke (9, 28) | 3.5118 | R |
| 8. | Cliff Lee (11, 33) | 3.4250 | L |
| 9. | Jered Weaver (7, 29) | 3.2012 | R |
| 10. | Jake Peavy (11, 31) | 3.1663 | R |
| 11. | Josh Beckett (12, 32) | 3.0967 | R |
| 12. | Justin Verlander (8, 29) | 3.0353 | R |
| 13. | Felix Hernandez (8, 26) | 3.0022 | R |
| 14. | Tim Lincecum (6, 28) | 2.9044 | R |
| 15. | Aaron Harang (11, 34) | 2.8374 | R |
| 16. | CC Sabathia (12, 31) | 2.7962 | L |
| 17. | Chris Carpenter (14, 37) | 2.7003 | R |
| 18. | Dave Bush (8, 32) | 2.6000 | R |
| 19. | Chris Capuano (8, 33) | 2.5821 | L |
| 20. | John Lackey (10, 33) | 2.5747 | R |
| 21. | Carl Pavano (14, 36) | 2.5684 | R |
| 22. | Ted Lilly (14, 36) | 2.5545 | L |
| 23. | Kevin Millwood (16, 37) | 2.4914 | R |
| 24. | Mark Buehrle (13, 33) | 2.4870 | L |
| 25. | Brett Myers (11, 31) | 2.4861 | R |
| 26. | Erik Bedard (9, 33) | 2.4734 | L |
| 27. | Ervin Santana (8, 29) | 2.4535 | R |
| 28. | Jon Lester (7, 28) | 2.4349 | L |
| 29. | Joe Blanton (9, 31) | 2.4318 | R |
| 30. | Wandy Rodriguez (8, 33) | 2.4119 | L |
| 31. | Kerry Wood (14, 35) | 2.3754 | R |
| 32. | Gavin Floyd (9, 29) | 2.3735 | R |
| 33. | Matt Cain (8, 27) | 2.3683 | R |
| 34. | Andy Pettitte (17, 40) | 2.3475 | L |
| 35. | Bartolo Colon (15, 39) | 2.3461 | R |
| 36. | Freddy Garcia (14, 35) | 2.2605 | R |
| 37. | Bronson Arroyo (13, 35) | 2.2575 | R |
| 38. | Tim Hudson (14, 36) | 2.2290 | R |
| 39. | Derek Lowe (16, 39) | 2.2124 | R |
| 40. | A.J. Burnett (14, 35) | 2.1838 | R |
| 41. | Joel Pineiro (12, 33) | 2.1725 | R |
| 42. | Randy Wolf (14, 35) | 2.1705 | L |
| 43. | Jeff Francis (7, 31) | 2.1288 | L |
| 44. | Jamie Moyer (25, 49) | 2.1134 | L |
| 45. | Kyle Lohse (12, 33) | 2.1101 | R |
| 46. | Jose Contreras (10, 40) | 2.0950 | R |
| 47. | Rodrigo Lopez (11, 36) | 2.0793 | R |
| 48. | Brett Tomko (14, 39) | 2.0773 | R |
| 49. | Chad Billingsley (7, 27) | 2.0582 | R |
| 50. | LaTroy Hawkins (18, 39) | 2.0264 | R |
| Rank | Player (yrs, age) | Strikeouts / Base On Balls | Throws |
| 51. | Vicente Padilla (14, 34) | 2.0129 | R |
| 52. | Bruce Chen (14, 35) | 2.0087 | L |
| 53. | Jeremy Guthrie (9, 33) | 2.0062 | R |
| 54. | Zach Duke (7, 29) | 1.9043 | L |
| 55. | Ryan Dempster (15, 35) | 1.9005 | R |
| 56. | Edwin Jackson (10, 28) | 1.8869 | R |
| 57. | Carlos Zambrano (12, 31) | 1.8718 | R |
| 58. | Nate Robertson (9, 34) | 1.8452 | L |
| 59. | Livan Hernandez (17, 37) | 1.8403 | R |
| 60. | Paul Maholm (8, 30) | 1.8396 | L |
| 61. | Ramon Ortiz (11, 39) | 1.8139 | R |
| 62. | Oliver Perez (9, 30) | 1.7930 | L |
| 63. | Dontrelle Willis (9, 30) | 1.7920 | L |
| 64. | Barry Zito (13, 34) | 1.7885 | L |
| 65. | Joe Saunders (8, 31) | 1.7812 | L |
| 66. | Jake Westbrook (12, 34) | 1.7588 | R |
| 67. | Darren Oliver (19, 41) | 1.7022 | L |
| 68. | Scott Elarton (10, 36) | 1.6699 | R |
| 69. | Doug Davis (13, 36) | 1.6335 | L |
| 70. | Jeff Suppan (17, 37) | 1.5959 | R |
| 71. | Kip Wells (11, 35) | 1.5350 | R |
| 72. | Jason Marquis (13, 33) | 1.4962 | R |
| 73. | Miguel Batista (18, 41) | 1.3964 | R |
| 74. | Aaron Cook (11, 33) | 1.3643 | R |
| 75. | Jamey Wright (17, 37) | 1.1440 | R |