+ - Indicates Hall of Famer. Bold indicates active player.
Statistic Description: SO/BB For recent years, leaders need 1 IP per team game played
Minimum of 1000 IP, 3000 PA, 500 games (fielding), 200 stolen base attempts (catchers) or 80 stolen base attempts (baserunners only since 1951) or 100 decisions for career and active leaderboards for rate statistics.
| Rank | Player (yrs, age) | Strikeouts / Base On Balls | Throws |
|---|---|---|---|
| 1. | Mariano Rivera (19, 43) | 4.0573 | R |
| 2. | Dan Haren (11, 32) | 4.0299 | R |
| 3. | Cole Hamels (8, 29) | 3.6885 | L |
| 4. | James Shields (8, 31) | 3.6808 | R |
| 5. | Roy Halladay (16, 36) | 3.6667 | R |
| Cliff Lee (12, 34) | 3.6667 | L | |
| 7. | Zack Greinke (10, 29) | 3.5316 | R |
| 8. | Johan Santana (12, 34) | 3.5062 | L |
| 9. | Ricky Nolasco (8, 30) | 3.4799 | R |
| 10. | Jake Peavy (12, 32) | 3.2356 | R |
| 11. | Felix Hernandez (9, 27) | 3.1653 | R |
| 12. | Adam Wainwright (8, 31) | 3.1574 | R |
| 13. | Jered Weaver (8, 30) | 3.1337 | R |
| 14. | Justin Verlander (9, 30) | 3.0963 | R |
| 15. | Josh Beckett (13, 33) | 3.0407 | R |
| 16. | Clayton Kershaw (6, 25) | 2.9078 | L |
| 17. | CC Sabathia (13, 32) | 2.8929 | L |
| 18. | Tim Lincecum (7, 29) | 2.7825 | R |
| 19. | Chris Carpenter (15, 38) | 2.7065 | R |
| 20. | Aaron Harang (12, 35) | 2.6721 | R |
| 21. | Chris Capuano (9, 34) | 2.6257 | L |
| 22. | Dave Bush (9, 33) | 2.5946 | R |
| 23. | Joe Blanton (10, 32) | 2.5887 | R |
| 24. | John Lackey (11, 34) | 2.5858 | R |
| 25. | Ted Lilly (15, 37) | 2.5527 | L |
| 26. | Mark Buehrle (14, 34) | 2.5138 | L |
| 27. | Ervin Santana (9, 30) | 2.5073 | R |
| 28. | Jon Lester (8, 29) | 2.4831 | L |
| 29. | Brett Myers (12, 32) | 2.4802 | R |
| 30. | Matt Garza (7, 29) | 2.4644 | R |
| 31. | Matt Cain (9, 28) | 2.4508 | R |
| 32. | Erik Bedard (10, 34) | 2.4212 | L |
| 33. | Wandy Rodriguez (9, 34) | 2.4074 | L |
| 34. | Bartolo Colon (16, 40) | 2.4000 | R |
| 35. | Andy Pettitte (18, 41) | 2.3658 | L |
| 36. | Bronson Arroyo (14, 36) | 2.3199 | R |
| 37. | Gavin Floyd (10, 30) | 2.3154 | R |
| 38. | Jeremy Bonderman (8, 30) | 2.2995 | R |
| 39. | Esteban Loaiza (14, 41) | 2.2881 | R |
| 40. | Freddy Garcia (15, 36) | 2.2799 | R |
| 41. | A.J. Burnett (15, 36) | 2.2525 | R |
| 42. | R.A. Dickey (11, 38) | 2.2422 | R |
| 43. | Tim Hudson (15, 37) | 2.2309 | R |
| 44. | Jeff Francis (9, 32) | 2.2127 | L |
| 45. | Kyle Lohse (13, 34) | 2.2104 | R |
| 46. | Derek Lowe (17, 40) | 2.1688 | R |
| 47. | Kelvim Escobar (12, 37) | 2.1440 | R |
| 48. | Scott Kazmir (9, 29) | 2.1227 | L |
| 49. | Chad Billingsley (8, 28) | 2.1120 | R |
| 50. | Jose Contreras (11, 41) | 2.0995 | R |
| Rank | Player (yrs, age) | Strikeouts / Base On Balls | Throws |
| 51. | Bruce Chen (15, 36) | 2.0931 | L |
| 52. | Rodrigo Lopez (11, 37) | 2.0793 | R |
| 53. | LaTroy Hawkins (19, 40) | 2.0587 | R |
| 54. | Jeremy Guthrie (10, 34) | 2.0404 | R |
| 55. | Ubaldo Jimenez (8, 29) | 1.9863 | R |
| 56. | Ryan Dempster (16, 36) | 1.9575 | R |
| 57. | Paul Maholm (9, 31) | 1.9558 | L |
| 58. | Edwin Jackson (11, 29) | 1.9555 | R |
| 59. | Mark Hendrickson (10, 39) | 1.9304 | L |
| 60. | Zach Duke (9, 30) | 1.9207 | L |
| 61. | Kevin Correia (11, 32) | 1.8869 | R |
| 62. | Nate Robertson (9, 35) | 1.8452 | L |
| 63. | Joe Saunders (9, 32) | 1.8333 | L |
| 64. | Oliver Perez (11, 31) | 1.8109 | L |
| 65. | Ramon Ortiz (12, 40) | 1.7980 | R |
| 66. | Barry Zito (14, 35) | 1.7917 | L |
| 67. | Jake Westbrook (13, 35) | 1.7440 | R |
| 68. | Darren Oliver (20, 42) | 1.7271 | L |
| 69. | Jon Garland (13, 33) | 1.6073 | R |
| 70. | Jason Marquis (14, 34) | 1.5431 | R |
| 71. | Kip Wells (12, 36) | 1.5165 | R |
| 72. | Miguel Batista (18, 42) | 1.3904 | R |
| 73. | Aaron Cook (11, 34) | 1.3473 | R |
| 74. | Jamey Wright (18, 38) | 1.1583 | R |