+ - Indicates Hall of Famer. Bold indicates active player.
Minimum of 1000 IP, 3000 PA, 500 games (fielding), 200 stolen base attempts (catchers) or 100 decisions for career and active leaderboards for rate statistics.
| Rank | Player (yrs, age) | Adjusted ERA+ | Throws |
|---|---|---|---|
| 1. | Mariano Rivera (17, 41) | 206 | R |
| 2. | Johan Santana (11, 32) | 142 | L |
| Brandon Webb (7, 32) | 142 | R | |
| 4. | Roy Halladay (14, 34) | 138 | R |
| Tim Lincecum (5, 27) | 138 | R | |
| 6. | Roy Oswalt (11, 33) | 133 | R |
| 7. | Felix Hernandez (7, 25) | 129 | R |
| 8. | Jered Weaver (6, 28) | 128 | R |
| 9. | Tim Hudson (13, 35) | 127 | R |
| 10. | Cole Hamels (6, 27) | 126 | L |
| 11. | Matt Cain (7, 26) | 125 | R |
| CC Sabathia (11, 30) | 125 | L | |
| 13. | Justin Verlander (7, 28) | 124 | R |
| 14. | Carlos Zambrano (11, 30) | 122 | R |
| 15. | Mark Buehrle (12, 32) | 120 | L |
| 16. | Dan Haren (9, 30) | 119 | R |
| 17. | Kerry Wood (13, 34) | 118 | R |
| 18. | Cliff Lee (10, 32) | 117 | L |
| 19. | Chris Carpenter (14, 36) | 116 | R |
| 20. | Josh Beckett (11, 31) | 115 | R |
| 21. | Zack Greinke (8, 27) | 114 | R |
| Jake Peavy (10, 30) | 114 | R | |
| 23. | Bartolo Colon (14, 38) | 112 | R |
| Derek Lowe (15, 38) | 112 | R | |
| 25. | Chad Billingsley (6, 26) | 111 | R |
| Barry Zito (12, 33) | 111 | L | |
| 27. | Freddy Garcia (13, 34) | 110 | R |
| 28. | Arthur Rhodes (20, 41) | 109 | L |
| 29. | John Lackey (10, 32) | 108 | R |
| 30. | Ted Lilly (13, 35) | 107 | L |
| Kevin Millwood (15, 36) | 107 | R | |
| 32. | Aaron Cook (10, 32) | 106 | R |
| James Shields (6, 29) | 106 | R | |
| 34. | A.J. Burnett (13, 34) | 105 | R |
| Jeremy Guthrie (8, 32) | 105 | R | |
| Scott Kazmir (8, 27) | 105 | L | |
| Javier Vazquez (14, 34) | 105 | R | |
| Tim Wakefield (19, 44) | 105 | R | |
| 39. | Bronson Arroyo (12, 34) | 104 | R |
| Ryan Franklin (12, 38) | 104 | R | |
| Jon Garland (12, 31) | 104 | R | |
| LaTroy Hawkins (17, 38) | 104 | R | |
| 43. | Darren Oliver (18, 40) | 103 | L |
| Randy Wolf (13, 34) | 103 | L | |
| 45. | Doug Davis (13, 35) | 102 | L |
| Elmer Dessens (14, 40) | 102 | R | |
| Wandy Rodriguez (7, 32) | 102 | L | |
| 48. | Miguel Batista (17, 40) | 101 | R |
| Jose Contreras (9, 39) | 101 | R | |
| Aaron Harang (10, 33) | 101 | R | |
| Rank | Player (yrs, age) | Adjusted ERA+ | Throws |
| Brad Penny (12, 33) | 101 | R | |
| Ervin Santana (7, 28) | 101 | R | |
| Dontrelle Willis (9, 29) | 101 | L | |
| 54. | Brett Myers (10, 30) | 100 | R |
| Vicente Padilla (13, 33) | 100 | R | |
| 56. | Joe Blanton (8, 30) | 99 | R |
| 57. | Ryan Dempster (14, 34) | 98 | R |
| Jeff Francis (7, 30) | 98 | L | |
| Carl Pavano (13, 35) | 98 | R | |
| Jake Westbrook (11, 33) | 98 | R | |
| 61. | Bruce Chen (13, 34) | 97 | L |
| Edwin Jackson (9, 27) | 97 | R | |
| Jason Marquis (12, 32) | 97 | R | |
| Jeff Suppan (16, 36) | 97 | R | |
| 65. | Livan Hernandez (16, 36) | 96 | R |
| Paul Maholm (7, 29) | 96 | L | |
| Joel Pineiro (12, 32) | 96 | R | |
| 68. | Jamey Wright (16, 36) | 95 | R |
| 69. | Kyle Lohse (11, 32) | 94 | R |
| 70. | Dave Bush (8, 31) | 93 | R |
| Zach Duke (7, 28) | 93 | L | |
| Carlos Silva (9, 32) | 93 | R | |
| Brett Tomko (14, 38) | 93 | R | |
| 74. | Rodrigo Lopez (10, 35) | 91 | R |
| Oliver Perez (9, 29) | 91 | L | |
| 76. | Ramon Ortiz (11, 38) | 90 | R |
| 77. | Mark Hendrickson (10, 37) | 89 | L |
| Nate Robertson (9, 33) | 89 | L |