+ - Indicates Hall of Famer. Bold indicates active player.
Statistic Description: 9 * ER / IP For recent years, leaders need 1 IP per team game played
Minimum of 1000 IP, 3000 PA, 500 games (fielding), 200 stolen base attempts (catchers) or 80 stolen base attempts (baserunners only since 1951) or 100 decisions for career and active leaderboards for rate statistics.
| Rank | Player (yrs, age) | Earned Run Average | Throws |
|---|---|---|---|
| 1. | Mariano Rivera (18, 42) | 2.214 | R |
| 2. | Johan Santana (12, 33) | 3.092 | L |
| 3. | Tim Lincecum (6, 28) | 3.146 | R |
| 4. | Felix Hernandez (8, 26) | 3.238 | R |
| 5. | Roy Halladay (15, 35) | 3.253 | R |
| 6. | Jered Weaver (7, 29) | 3.268 | R |
| 7. | Matt Cain (8, 27) | 3.326 | R |
| 8. | Cole Hamels (7, 28) | 3.339 | L |
| 9. | Tim Hudson (14, 36) | 3.416 | R |
| 10. | Jake Peavy (11, 31) | 3.455 | R |
| 11. | Justin Verlander (8, 29) | 3.462 | R |
| 12. | CC Sabathia (12, 31) | 3.518 | L |
| 13. | Carlos Zambrano (12, 31) | 3.581 | R |
| 14. | Dan Haren (10, 31) | 3.596 | R |
| 15. | Jon Lester (7, 28) | 3.605 | L |
| 16. | Cliff Lee (11, 33) | 3.621 | L |
| 17. | Erik Bedard (9, 33) | 3.669 | L |
| 18. | Kerry Wood (14, 35) | 3.672 | R |
| 19. | Chad Billingsley (7, 27) | 3.686 | R |
| 20. | Chris Carpenter (14, 37) | 3.760 | R |
| 21. | Mark Buehrle (13, 33) | 3.811 | L |
| 22. | Zack Greinke (9, 28) | 3.812 | R |
| 23. | Josh Beckett (12, 32) | 3.847 | R |
| 24. | Andy Pettitte (17, 40) | 3.870 | L |
| 25. | Barry Zito (13, 34) | 3.900 | L |
| 26. | Derek Lowe (16, 39) | 3.923 | R |
| 27. | James Shields (7, 30) | 3.944 | R |
| 28. | Wandy Rodriguez (8, 33) | 3.980 | L |
| 29. | Kevin Millwood (16, 37) | 4.091 | R |
| 30. | Bartolo Colon (15, 39) | 4.101 | R |
| 31. | John Lackey (10, 33) | 4.102 | R |
| 32. | A.J. Burnett (14, 35) | 4.106 | R |
| 33. | Randy Wolf (14, 35) | 4.131 | L |
| 34. | Ted Lilly (14, 36) | 4.133 | L |
| 35. | Freddy Garcia (14, 35) | 4.137 | R |
| 36. | Joe Saunders (8, 31) | 4.139 | L |
| 37. | Dontrelle Willis (9, 30) | 4.170 | L |
| 38. | Brett Myers (11, 31) | 4.213 | R |
| 39. | Ervin Santana (8, 29) | 4.228 | R |
| 40. | Jeremy Guthrie (9, 33) | 4.233 | R |
| 41. | Aaron Harang (11, 34) | 4.251 | R |
| 42. | Chris Capuano (8, 33) | 4.252 | L |
| 43. | Jamie Moyer (25, 49) | 4.255 | L |
| 44. | Bronson Arroyo (13, 35) | 4.260 | R |
| 45. | Jake Westbrook (12, 34) | 4.303 | R |
| 46. | Vicente Padilla (14, 34) | 4.327 | R |
| 47. | Joe Blanton (9, 31) | 4.331 | R |
| 48. | Ryan Dempster (15, 35) | 4.356 | R |
| 49. | Paul Maholm (8, 30) | 4.371 | L |
| Carl Pavano (14, 36) | 4.371 | R | |
| Rank | Player (yrs, age) | Earned Run Average | Throws |
| 51. | Livan Hernandez (17, 37) | 4.387 | R |
| 52. | Edwin Jackson (10, 28) | 4.406 | R |
| 53. | Joel Pineiro (12, 33) | 4.407 | R |
| 54. | Doug Davis (13, 36) | 4.438 | L |
| 55. | LaTroy Hawkins (18, 39) | 4.457 | R |
| 56. | Miguel Batista (18, 41) | 4.470 | R |
| 57. | Gavin Floyd (9, 29) | 4.526 | R |
| 58. | Bruce Chen (14, 35) | 4.534 | L |
| 59. | Jose Contreras (10, 40) | 4.550 | R |
| 60. | Aaron Cook (11, 33) | 4.558 | R |
| 61. | Zach Duke (7, 29) | 4.565 | L |
| 62. | Darren Oliver (19, 41) | 4.576 | L |
| 63. | Kyle Lohse (12, 33) | 4.579 | R |
| 64. | Jason Marquis (13, 33) | 4.627 | R |
| 65. | Oliver Perez (9, 30) | 4.631 | L |
| 66. | Brett Tomko (14, 39) | 4.654 | R |
| 67. | Dave Bush (8, 32) | 4.700 | R |
| 68. | Jeff Suppan (17, 37) | 4.701 | R |
| 69. | Kip Wells (11, 35) | 4.711 | R |
| 70. | Jeff Francis (7, 31) | 4.780 | L |
| 71. | Rodrigo Lopez (11, 36) | 4.824 | R |
| 72. | Jamey Wright (17, 37) | 4.925 | R |
| 73. | Ramon Ortiz (11, 39) | 4.927 | R |
| 74. | Nate Robertson (9, 34) | 5.014 | L |
| 75. | Scott Elarton (10, 36) | 5.288 | R |