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Single-Season Leaders & Records for Strikeouts
+ - Indicates Hall of Famer. Bold indicates active player.
Only players who finished in the top 40 for the majors in a season will appear on this list. Leaders from the current season are only included for rate stats after July 1st.
| Rank | Player (age that year) | Strikeouts | Year | Throws |
|---|---|---|---|---|
| 1. | Matt Kilroy (20) | 513 | 1886 | L |
| 2. | Toad Ramsey (21) | 499 | 1886 | L |
| 3. | Hugh Daily (36) | 483 | 1884 | R |
| 4. | Dupee Shaw (25) | 451 | 1884 | L |
| 5. | Charley Radbourn+ (29) | 441 | 1884 | R |
| 6. | Charlie Buffinton (23) | 417 | 1884 | R |
| 7. | Guy Hecker (28) | 385 | 1884 | R |
| 8. | Nolan Ryan+ (26) | 383 | 1973 | R |
| 9. | Sandy Koufax+ (29) | 382 | 1965 | L |
| 10. | Bill Sweeney () | 374 | 1884 | R |
| 11. | Randy Johnson (37) | 372 | 2001 | L |
| 12. | Pud Galvin+ (27) | 369 | 1884 | R |
| 13. | Mark Baldwin (25) | 368 | 1889 | R |
| 14. | Nolan Ryan+ (27) | 367 | 1974 | R |
| 15. | Randy Johnson (35) | 364 | 1999 | L |
| 16. | Tim Keefe+ (26) | 361 | 1883 | R |
| 17. | Toad Ramsey (22) | 355 | 1887 | L |
| 18. | Rube Waddell+ (27) | 349 | 1904 | L |
| 19. | Bob Feller+ (27) | 348 | 1946 | R |
| 20. | Randy Johnson (36) | 347 | 2000 | L |
| 21. | Hardie Henderson (21) | 346 | 1884 | R |
| 22. | Mickey Welch+ (24) | 345 | 1884 | R |
| Jim Whitney (25) | 345 | 1883 | R | |
| 24. | Jim McCormick (27) | 343 | 1884 | R |
| 25. | Amos Rusie+ (19) | 341 | 1890 | R |
| Nolan Ryan+ (30) | 341 | 1977 | R | |
| 27. | Amos Rusie+ (20) | 337 | 1891 | R |
| Charlie Sweeney (21) | 337 | 1884 | R | |
| 29. | Tim Keefe+ (31) | 335 | 1888 | R |
| 30. | Randy Johnson (38) | 334 | 2002 | L |
| Tim Keefe+ (27) | 334 | 1884 | R | |
| 32. | Randy Johnson (34) | 329 | 1998 | L |
| Nolan Ryan+ (25) | 329 | 1972 | R | |
| 34. | Nolan Ryan+ (29) | 327 | 1976 | R |
| 35. | Ed Morris (23) | 326 | 1886 | L |
| 36. | Sam McDowell (22) | 325 | 1965 | L |
| Tony Mullane (25) | 325 | 1884 | R | |
| 38. | Lady Baldwin (27) | 323 | 1886 | L |
| 39. | Curt Schilling (30) | 319 | 1997 | R |
| 40. | Sandy Koufax+ (30) | 317 | 1966 | L |
| 41. | Curt Schilling (35) | 316 | 2002 | R |
| 42. | Charley Radbourn+ (28) | 315 | 1883 | R |
| 43. | Bill Hutchison (32) | 314 | 1892 | R |
| 44. | John Clarkson+ (24) | 313 | 1886 | R |
| Walter Johnson+ (22) | 313 | 1910 | R | |
| Pedro Martinez (27) | 313 | 1999 | R | |
| J.R. Richard (29) | 313 | 1979 | R | |
| 48. | Steve Carlton+ (27) | 310 | 1972 | L |
| 49. | John Clarkson+ (23) | 308 | 1885 | R |
| Randy Johnson (29) | 308 | 1993 | L | |
| Rank | Player (age that year) | Strikeouts | Year | Throws |
| Mickey Lolich (30) | 308 | 1971 | L | |
| Larry McKeon (18) | 308 | 1884 | ||
| 53. | Sandy Koufax+ (27) | 306 | 1963 | L |
| Mike Scott (31) | 306 | 1986 | R | |
| 55. | Pedro Martinez (25) | 305 | 1997 | R |
| 56. | Sam McDowell (27) | 304 | 1970 | L |
| 57. | Walter Johnson+ (24) | 303 | 1912 | R |
| J.R. Richard (28) | 303 | 1978 | R | |
| 59. | Ed Morris (21) | 302 | 1884 | L |
| Rube Waddell+ (26) | 302 | 1903 | L | |
| 61. | Vida Blue (21) | 301 | 1971 | L |
| Nolan Ryan+ (42) | 301 | 1989 | R | |
| 63. | Curt Schilling (31) | 300 | 1998 | R |
| 64. | Ed Morris (22) | 298 | 1885 | L |
| 65. | Tim Keefe+ (29) | 297 | 1886 | R |
| 66. | Randy Johnson (31) | 294 | 1995 | L |
| 67. | Curt Schilling (34) | 293 | 2001 | R |
| 68. | Roger Clemens (34) | 292 | 1997 | R |
| Jack Lynch (27) | 292 | 1884 | R | |
| 70. | Roger Clemens (25) | 291 | 1988 | R |
| Randy Johnson (33) | 291 | 1997 | L | |
| Sadie McMahon (22) | 291 | 1890 | R | |
| 73. | Randy Johnson (40) | 290 | 2004 | L |
| 74. | Bill Hutchison (30) | 289 | 1890 | R |
| Tom Seaver+ (26) | 289 | 1971 | R | |
| Jack Stivetts (22) | 289 | 1890 | R | |
| 77. | Amos Rusie+ (21) | 288 | 1892 | R |
| 78. | Rube Waddell+ (28) | 287 | 1905 | L |
| 79. | Steve Carlton+ (35) | 286 | 1980 | L |
| Steve Carlton+ (37) | 286 | 1982 | L | |
| Bobby Mathews (32) | 286 | 1884 | R | |
| Bobby Mathews (33) | 286 | 1885 | R | |
| 83. | John Clarkson+ (27) | 284 | 1889 | R |
| Pedro Martinez (28) | 284 | 2000 | R | |
| Billy Taylor (29) | 284 | 1884 | R | |
| 86. | Dave Foutz (29) | 283 | 1886 | R |
| Sam McDowell (25) | 283 | 1968 | L | |
| Tom Seaver+ (25) | 283 | 1970 | R | |
| 89. | Denny McLain (24) | 280 | 1968 | R |
| 90. | Pud Galvin+ (26) | 279 | 1883 | R |
| Sam McDowell (26) | 279 | 1969 | L | |
| 92. | Dwight Gooden (19) | 276 | 1984 | R |
| John Smoltz (29) | 276 | 1996 | R | |
| Bob Veale (29) | 276 | 1965 | L | |
| 95. | Steve Carlton+ (38) | 275 | 1983 | L |
| Hal Newhouser+ (25) | 275 | 1946 | L | |
| 97. | Bob Gibson+ (34) | 274 | 1970 | R |
| Fergie Jenkins+ (27) | 274 | 1970 | R | |
| Mario Soto (25) | 274 | 1982 | R | |
| 100. | Fergie Jenkins+ (26) | 273 | 1969 | R |
| Rank | Player (age that year) | Strikeouts | Year | Throws |
| 101. | Larry Corcoran (24) | 272 | 1884 | R |
| Ed Seward (21) | 272 | 1888 | R | |
| Mickey Welch+ (26) | 272 | 1886 | R | |
| 104. | Roger Clemens (35) | 271 | 1998 | R |
| Mickey Lolich (28) | 271 | 1969 | L | |
| 106. | Bob Gibson+ (29) | 270 | 1965 | R |
| Nolan Ryan+ (40) | 270 | 1987 | R | |
| Jim Whitney (26) | 270 | 1884 | R | |
| 109. | Bob Gibson+ (33) | 269 | 1969 | R |
| Sandy Koufax+ (25) | 269 | 1961 | L | |
| Frank Tanana (21) | 269 | 1975 | L | |
| Ed Walsh+ (27) | 269 | 1908 | R | |
| 113. | Jim Bunning+ (33) | 268 | 1965 | R |
| Larry Corcoran (20) | 268 | 1880 | R | |
| Bob Gibson+ (32) | 268 | 1968 | R | |
| Dwight Gooden (20) | 268 | 1985 | R | |
| Bill Wise (23) | 268 | 1884 | ||
| 118. | Christy Mathewson+ (22) | 267 | 1903 | R |
| 119. | Kerry Wood (26) | 266 | 2003 | R |
| 120. | Tim Lincecum (24) | 265 | 2008 | R |
| Jim Maloney (23) | 265 | 1963 | R | |
| Johan Santana (25) | 265 | 2004 | L | |
| 123. | Bob Emslie (25) | 264 | 1884 | R |
| Ben Sheets (25) | 264 | 2004 | R | |
| Luis Tiant (27) | 264 | 1968 | R | |
| 126. | Hardie Henderson (22) | 263 | 1885 | R |
| Fergie Jenkins+ (28) | 263 | 1971 | R | |
| Herb Score (23) | 263 | 1956 | L | |
| 129. | Mark Langston (26) | 262 | 1987 | L |
| Phil Niekro+ (38) | 262 | 1977 | R | |
| Dazzy Vance+ (33) | 262 | 1924 | R | |
| 132. | David Cone (29) | 261 | 1992 | R |
| Bob Feller+ (21) | 261 | 1940 | R | |
| Bill Hutchison (31) | 261 | 1891 | R | |
| Frank Tanana (22) | 261 | 1976 | L | |
| 136. | Bob Feller+ (22) | 260 | 1941 | R |
| Fergie Jenkins+ (25) | 260 | 1968 | R | |
| Jim McCormick (23) | 260 | 1880 | R | |
| Nolan Ryan+ (31) | 260 | 1978 | R | |
| 140. | Christy Mathewson+ (27) | 259 | 1908 | R |
| Jack Stivetts (23) | 259 | 1891 | R | |
| 142. | Bert Blyleven (22) | 258 | 1973 | R |
| Silver King (20) | 258 | 1888 | R | |
| Ed Walsh+ (29) | 258 | 1910 | R | |
| Mickey Welch+ (25) | 258 | 1885 | R | |
| Joe Wood (22) | 258 | 1912 | R | |
| 147. | Kevin Brown (33) | 257 | 1998 | R |
| Roger Clemens (33) | 257 | 1996 | R | |
| Toad Ramsey (25) | 257 | 1890 | L | |
| 150. | Roger Clemens (24) | 256 | 1987 | R |
| Rank | Player (age that year) | Strikeouts | Year | Throws |
| 151. | James Burke () | 255 | 1884 | |
| Ed Walsh+ (30) | 255 | 1911 | R | |
| 153. | Ed Walsh+ (31) | 254 | 1912 | R |
| 154. | Jim Bunning+ (35) | 253 | 1967 | R |
| 155. | Jim Bunning+ (34) | 252 | 1966 | R |
| 156. | Don Drysdale+ (26) | 251 | 1963 | R |
| Pedro Martinez (26) | 251 | 1998 | R | |
| C.C. Sabathia (27) | 251 | 2008 | L | |
| Jason Schmidt (31) | 251 | 2004 | R | |
| Tom Seaver+ (28) | 251 | 1973 | R | |
| Bill Stoneman (27) | 251 | 1971 | R | |
| 162. | Mickey Lolich (31) | 250 | 1972 | L |
| Tony Mullane (27) | 250 | 1886 | R | |
| Bob Veale (28) | 250 | 1964 | L | |
| 165. | Bert Blyleven (23) | 249 | 1974 | R |
| Tom Seaver+ (27) | 249 | 1972 | R | |
| 167. | Ron Guidry (27) | 248 | 1978 | L |
| Juan Marichal+ (25) | 248 | 1963 | R | |
| Phil Niekro+ (39) | 248 | 1978 | R | |
| 170. | Al Atkinson (23) | 247 | 1884 | R |
| Bill Singer (25) | 247 | 1969 | R | |
| 172. | Don Drysdale+ (23) | 246 | 1960 | R |
| Bob Feller+ (20) | 246 | 1939 | R | |
| Jim Lonborg (25) | 246 | 1967 | R | |
| 175. | Bob Gibson+ (28) | 245 | 1964 | R |
| Mark Langston (25) | 245 | 1986 | L | |
| Mark Prior (22) | 245 | 2003 | R | |
| Nolan Ryan+ (35) | 245 | 1982 | R | |
| Johan Santana (27) | 245 | 2006 | L | |
| Herb Score (22) | 245 | 1955 | L | |
| 181. | Dennis Leonard (26) | 244 | 1977 | R |
| Jim Maloney (25) | 244 | 1965 | R | |
| 183. | Walter Johnson+ (25) | 243 | 1913 | R |
| Lee Richmond (23) | 243 | 1880 | L | |
| Tom Seaver+ (30) | 243 | 1975 | R | |
| 186. | Charlie Buffinton (24) | 242 | 1885 | R |
| Don Drysdale+ (22) | 242 | 1959 | R | |
| Mario Soto (26) | 242 | 1983 | R | |
| Fernando Valenzuela (25) | 242 | 1986 | L | |
| 190. | Pete Alexander+ (28) | 241 | 1915 | R |
| Roger Clemens (28) | 241 | 1991 | R | |
| David Cone (28) | 241 | 1991 | R | |
| Randy Johnson (28) | 241 | 1992 | L | |
| Bill Singer (29) | 241 | 1973 | R | |
| John Smoltz (30) | 241 | 1997 | R | |
| Javier Vazquez (26) | 241 | 2003 | R | |
| 197. | Steve Carlton+ (29) | 240 | 1974 | L |
| Bob Feller+ (19) | 240 | 1938 | R | |
| Teddy Higuera (28) | 240 | 1987 | L | |
| Juan Marichal+ (27) | 240 | 1965 | R | |
| Rank | Player (age that year) | Strikeouts | Year | Throws |
| Kid Nichols+ (21) | 240 | 1891 | R | |
| Jake Peavy (26) | 240 | 2007 | R | |
| Fernando Valenzuela (23) | 240 | 1984 | L | |
| 204. | Jack Chesbro+ (30) | 239 | 1904 | R |
| Noodles Hahn (22) | 239 | 1901 | L | |
| Scott Kazmir (23) | 239 | 2007 | L | |
| Pedro Martinez (30) | 239 | 2002 | R | |
| Oliver Perez (22) | 239 | 2004 | L | |
| Cy Seymour (25) | 239 | 1898 | L | |
| Bill Stemmeyer (21) | 239 | 1886 | R | |
| John Ward+ (19) | 239 | 1879 | R | |
| 212. | Roger Clemens (23) | 238 | 1986 | R |
| Van Mungo (25) | 238 | 1936 | R | |
| Gaylord Perry+ (34) | 238 | 1973 | R | |
| Johan Santana (26) | 238 | 2005 | L | |
| 216. | John Clarkson+ (25) | 237 | 1887 | R |
| Don Drysdale+ (27) | 237 | 1964 | R | |
| Rube Marquard+ (24) | 237 | 1911 | L | |
| Chris Short (27) | 237 | 1965 | L | |
| 220. | Joe Coleman (24) | 236 | 1971 | R |
| Cy Falkenberg (33) | 236 | 1914 | R | |
| Fergie Jenkins+ (24) | 236 | 1967 | R | |
| Sam McDowell (24) | 236 | 1967 | L | |
| Hideo Nomo (26) | 236 | 1995 | R | |
| 225. | Mark Langston (27) | 235 | 1988 | L |
| Mark Langston (28) | 235 | 1989 | L | |
| Johan Santana (28) | 235 | 2007 | L | |
| Tom Seaver+ (31) | 235 | 1976 | R | |
| Don Wilson (24) | 235 | 1969 | R | |
| 230. | Dean Chance (27) | 234 | 1968 | R |
| Hideo Nomo (27) | 234 | 1996 | R | |
| Gaylord Perry+ (33) | 234 | 1972 | R | |
| 233. | Bert Blyleven (24) | 233 | 1975 | R |
| David Cone (27) | 233 | 1990 | R | |
| Hideo Nomo (28) | 233 | 1997 | R | |
| Gaylord Perry+ (30) | 233 | 1969 | R | |
| Gaylord Perry+ (36) | 233 | 1975 | R | |
| Mike Scott (32) | 233 | 1987 | R | |
| Kerry Wood (21) | 233 | 1998 | R | |
| 240. | Larry Dierker (22) | 232 | 1969 | R |
| Don Drysdale+ (25) | 232 | 1962 | R | |
| Jack Morris (28) | 232 | 1983 | R | |
| Nolan Ryan+ (43) | 232 | 1990 | R | |
| Rube Waddell+ (30) | 232 | 1907 | L | |
| Rube Waddell+ (31) | 232 | 1908 | L | |
| Will White (24) | 232 | 1879 | R | |
| 247. | A.J. Burnett (31) | 231 | 2008 | R |
| Clay Kirby (23) | 231 | 1971 | R | |
| Joe Wood (21) | 231 | 1911 | R | |
| 250. | Roger Clemens (26) | 230 | 1989 | R |
| Rank | Player (age that year) | Strikeouts | Year | Throws |
| Mickey Lolich (29) | 230 | 1970 | L | |
| Gaylord Perry+ (28) | 230 | 1967 | R | |
| Adonis Terry (19) | 230 | 1884 | R | |
| John Ward+ (20) | 230 | 1880 | R | |
| 255. | Dave Davenport (25) | 229 | 1915 | R |
| Bob Veale (30) | 229 | 1966 | L | |
| 257. | Bert Blyleven (21) | 228 | 1972 | R |
| Randy Johnson (27) | 228 | 1991 | L | |
| Walter Johnson+ (28) | 228 | 1916 | R | |
| Phil Knell (26) | 228 | 1891 | L | |
| Toad Ramsey (23) | 228 | 1888 | L | |
| Nolan Ryan+ (41) | 228 | 1988 | R | |
| 263. | Pete Alexander+ (24) | 227 | 1911 | R |
| Tim Keefe+ (28) | 227 | 1885 | R | |
| Pedro Martinez (32) | 227 | 2004 | R | |
| Jose Rijo (28) | 227 | 1993 | R | |
| Bill Singer (24) | 227 | 1968 | R | |
| 268. | Jersey Bakely (20) | 226 | 1884 | R |
| Bill Donovan (24) | 226 | 1901 | R | |
| Mickey Lolich (24) | 226 | 1965 | L | |
| Bobo Newsom (30) | 226 | 1938 | R | |
| Tom Seaver+ (33) | 226 | 1978 | R | |
| 273. | Bob Gibson+ (30) | 225 | 1966 | R |
| John Healy (23) | 225 | 1890 | R | |
| Tom Hughes (22) | 225 | 1901 | R | |
| Fergie Jenkins+ (31) | 225 | 1974 | R | |
| Walter Johnson+ (26) | 225 | 1914 | R | |
| Sam Jones (32) | 225 | 1958 | R | |
| Tim Keefe+ (32) | 225 | 1889 | R | |
| Sam McDowell (23) | 225 | 1966 | L | |
| Vic Willis+ (26) | 225 | 1902 | R | |
| 282. | Bert Blyleven (20) | 224 | 1971 | R |
| Jack Coombs (27) | 224 | 1910 | R | |
| 284. | Steve Carlton+ (28) | 223 | 1973 | L |
| John Clarkson+ (26) | 223 | 1888 | R | |
| Dwight Gooden (25) | 223 | 1990 | R | |
| Charlie Hough (39) | 223 | 1987 | R | |
| Sandy Koufax+ (28) | 223 | 1964 | L | |
| Ramon Martinez (22) | 223 | 1990 | R | |
| Jack Morris (31) | 223 | 1986 | R | |
| Nolan Ryan+ (32) | 223 | 1979 | R | |
| 292. | Joe Coleman (25) | 222 | 1972 | R |
| David Cone (34) | 222 | 1997 | R | |
| Jeff Fassero (33) | 222 | 1996 | L | |
| Kid Gleason (23) | 222 | 1890 | R | |
| Juan Marichal+ (28) | 222 | 1966 | R | |
| Pedro Martinez (24) | 222 | 1996 | R | |
| Kid Nichols+ (20) | 222 | 1890 | R | |
| 299. | Erik Bedard (28) | 221 | 2007 | L |
| Kevin Brown (34) | 221 | 1999 | R | |
| Rank | Player (age that year) | Strikeouts | Year | Throws |
| Christy Mathewson+ (20) | 221 | 1901 | R | |
| Andy Messersmith (28) | 221 | 1974 | R | |
| Camilo Pascual (27) | 221 | 1961 | R | |
| Dazzy Vance+ (34) | 221 | 1925 | R | |
| Bobby Witt (26) | 221 | 1990 | R | |
| 306. | Dean Chance (26) | 220 | 1967 | R |
| Hideo Nomo (32) | 220 | 2001 | R | |
| 308. | Bert Blyleven (25) | 219 | 1976 | R |
| Jim Bunning+ (32) | 219 | 1964 | R | |
| Darryl Kile (27) | 219 | 1996 | R | |
| Sadie McMahon (23) | 219 | 1891 | R | |
| Luis Tiant (26) | 219 | 1967 | R | |
| Gus Weyhing (24) | 219 | 1891 | R | |
| 314. | Roger Clemens (41) | 218 | 2004 | R |
| Aaron Harang (29) | 218 | 2007 | R | |
| Juan Marichal+ (30) | 218 | 1968 | R | |
| Mike Mussina (28) | 218 | 1997 | R | |
| Chan Ho Park (28) | 218 | 2001 | R | |
| Melido Perez (26) | 218 | 1992 | R | |
| Charley Radbourn+ (31) | 218 | 1886 | R | |
| 321. | Al Downing (23) | 217 | 1964 | L |
| Matt Kilroy (21) | 217 | 1887 | L | |
| Matt Kilroy (23) | 217 | 1889 | L | |
| Chan Ho Park (27) | 217 | 2000 | R | |
| Don Sutton+ (24) | 217 | 1969 | R | |
| Kerry Wood (24) | 217 | 2001 | R | |
| Kerry Wood (25) | 217 | 2002 | R | |
| 328. | Kevin Brown (35) | 216 | 2000 | R |
| Larry Corcoran (23) | 216 | 1883 | R | |
| Aaron Harang (28) | 216 | 2006 | R | |
| Sandy Koufax+ (26) | 216 | 1962 | L | |
| Jim Maloney (26) | 216 | 1966 | R | |
| Jake Peavy (24) | 216 | 2005 | R | |
| Gaylord Perry+ (35) | 216 | 1974 | R | |
| 335. | Bert Blyleven (35) | 215 | 1986 | R |
| Matt Clement (27) | 215 | 2002 | R | |
| Chuck Finley (33) | 215 | 1996 | L | |
| John Montefusco (25) | 215 | 1975 | R | |
| Jake Peavy (25) | 215 | 2006 | R | |
| Gary Peters (30) | 215 | 1967 | L | |
| John Smoltz (25) | 215 | 1992 | R | |
| 342. | Pete Alexander+ (27) | 214 | 1914 | R |
| Mickey Lolich (32) | 214 | 1973 | L | |
| Jim Maloney (24) | 214 | 1964 | R | |
| Mike Mussina (32) | 214 | 2001 | R | |
| Gaylord Perry+ (31) | 214 | 1970 | R | |
| J.R. Richard (26) | 214 | 1976 | R | |
| J.R. Richard (27) | 214 | 1977 | R | |
| Ervin Santana (25) | 214 | 2008 | R | |
| Mario Soto (28) | 214 | 1985 | R | |
| Rank | Player (age that year) | Strikeouts | Year | Throws |
| 351. | Steve Carlton+ (34) | 213 | 1979 | L |
| Chris Carpenter (30) | 213 | 2005 | R | |
| Roger Clemens (38) | 213 | 2001 | R | |
| David Cone (25) | 213 | 1988 | R | |
| John Healy (19) | 213 | 1886 | R | |
| Andy Messersmith (29) | 213 | 1975 | R | |
| Camilo Pascual (30) | 213 | 1964 | R | |
| Rick Sutcliffe (28) | 213 | 1984 | R | |
| Javier Vazquez (30) | 213 | 2007 | R | |
| Bob Veale (33) | 213 | 1969 | L | |
| Gus Weyhing (22) | 213 | 1889 | R | |
| 362. | Jersey Bakely (24) | 212 | 1888 | R |
| Bartolo Colon (27) | 212 | 2000 | R | |
| George Derby (23) | 212 | 1881 | R | |
| Charlie Ferguson (23) | 212 | 1886 | R | |
| Chuck Finley (35) | 212 | 1998 | L | |
| Christy Mathewson+ (23) | 212 | 1904 | R | |
| Hal Newhouser+ (24) | 212 | 1945 | L | |
| 369. | Mark Baldwin (26) | 211 | 1890 | R |
| Tony Cloninger (24) | 211 | 1965 | R | |
| Erik Hanson (25) | 211 | 1990 | R | |
| Randy Johnson (41) | 211 | 2005 | L | |
| Jim Kaat (28) | 211 | 1967 | L | |
| Andy Messersmith (23) | 211 | 1969 | R | |
| John Smoltz (39) | 211 | 2006 | R | |
| Frank Viola (29) | 211 | 1989 | L | |
| 377. | Pedro Astacio (29) | 210 | 1999 | R |
| Steve Carlton+ (24) | 210 | 1969 | L | |
| Don Drysdale+ (28) | 210 | 1965 | R | |
| Mike Mussina (31) | 210 | 2000 | R | |
| Eddie Plank+ (29) | 210 | 1905 | L | |
| Bob Turley (24) | 210 | 1955 | R | |
| Rube Waddell+ (25) | 210 | 1902 | L | |
| Wilbur Wood (29) | 210 | 1971 | L | |
| Cy Young+ (38) | 210 | 1905 | R | |
| Carlos Zambrano (25) | 210 | 2006 | R | |
| 387. | Floyd Bannister (27) | 209 | 1982 | L |
| Bob Barr (33) | 209 | 1890 | R | |
| Tom Bradley (25) | 209 | 1972 | R | |
| Roger Clemens (27) | 209 | 1990 | R | |
| David Cone (35) | 209 | 1998 | R | |
| Ryan Dempster (23) | 209 | 2000 | R | |
| Russ Ford (27) | 209 | 1910 | R | |
| Whitey Ford+ (32) | 209 | 1961 | L | |
| Lefty Grove+ (30) | 209 | 1930 | L | |
| Guy Hecker (29) | 209 | 1885 | R | |
| Sam Jones (33) | 209 | 1959 | R | |
| Shane Reynolds (30) | 209 | 1998 | R | |
| Nolan Ryan+ (38) | 209 | 1985 | R | |
| C.C. Sabathia (26) | 209 | 2007 | L | |
| Rank | Player (age that year) | Strikeouts | Year | Throws |
| Don Sutton+ (21) | 209 | 1966 | R | |
| 402. | Roger Clemens (29) | 208 | 1992 | R |
| Doug Davis (29) | 208 | 2005 | L | |
| Jose DeLeon (27) | 208 | 1988 | R | |
| Bob Gibson+ (26) | 208 | 1962 | R | |
| Bob Gibson+ (36) | 208 | 1972 | R | |
| Pedro Martinez (33) | 208 | 2005 | R | |
| Jack Morris (32) | 208 | 1987 | R | |
| Brett Myers (24) | 208 | 2005 | R | |
| Phil Niekro+ (40) | 208 | 1979 | R | |
| Roy Oswalt (24) | 208 | 2002 | R | |
| Amos Rusie+ (22) | 208 | 1893 | R | |
| Jason Schmidt (30) | 208 | 2003 | R | |
| Tom Seaver+ (24) | 208 | 1969 | R | |
| John Smoltz (26) | 208 | 1993 | R | |
| Fernando Valenzuela (24) | 208 | 1985 | L | |
| Javier Vazquez (24) | 208 | 2001 | R | |
| Mike Witt (25) | 208 | 1986 | R | |
| 419. | Kevin Appier (28) | 207 | 1996 | R |
| Bob Barr (27) | 207 | 1884 | R | |
| Dean Chance (23) | 207 | 1964 | R | |
| Teddy Higuera (27) | 207 | 1986 | L | |
| Walter Johnson+ (23) | 207 | 1911 | R | |
| Esteban Loaiza (31) | 207 | 2003 | R | |
| Scott Stratton (20) | 207 | 1890 | R | |
| Don Sutton+ (27) | 207 | 1972 | R | |
| 427. | Bert Blyleven (34) | 206 | 1985 | R |
| Tom Bradley (24) | 206 | 1971 | R | |
| Roy Halladay (31) | 206 | 2008 | R | |
| Danny Haren (27) | 206 | 2008 | R | |
| Bob Johnson (27) | 206 | 1970 | R | |
| Juan Marichal+ (26) | 206 | 1964 | R | |
| Pedro Martinez (31) | 206 | 2003 | R | |
| Christy Mathewson+ (24) | 206 | 1905 | R | |
| Gary Nolan (19) | 206 | 1967 | R | |
| Roy Oswalt (26) | 206 | 2004 | R | |
| Camilo Pascual (28) | 206 | 1962 | R | |
| Steve Rogers (27) | 206 | 1977 | R | |
| Ray Sadecki (27) | 206 | 1968 | L | |
| Johan Santana (29) | 206 | 2008 | L | |
| Phenomenal Smith (22) | 206 | 1887 | L | |
| Luis Tiant (32) | 206 | 1973 | R | |
| Edinson Volquez (24) | 206 | 2008 | R | |
| Ed Walsh+ (26) | 206 | 1907 | R | |
| 445. | Kevin Brown (32) | 205 | 1997 | R |
| Jim Kaat (27) | 205 | 1966 | L | |
| Darryl Kile (28) | 205 | 1997 | R | |
| Juan Marichal+ (31) | 205 | 1969 | R | |
| Jon Matlack (23) | 205 | 1973 | L | |
| Kevin Millwood (24) | 205 | 1999 | R | |
| Rank | Player (age that year) | Strikeouts | Year | Throws |
| Earl Moseley (26) | 205 | 1914 | R | |
| Orval Overall (28) | 205 | 1909 | R | |
| Gary Peters (27) | 205 | 1964 | L | |
| Tom Seaver+ (23) | 205 | 1968 | R | |
| Dave Stewart (30) | 205 | 1987 | R | |
| Todd Stottlemyre (30) | 205 | 1995 | R | |
| Frank Tanana (23) | 205 | 1977 | L | |
| Stan Williams (24) | 205 | 1961 | R | |
| Barry Zito (23) | 205 | 2001 | L | |
| 460. | Dave Boswell (22) | 204 | 1967 | R |
| Elton Chamberlain (23) | 204 | 1891 | R | |
| Bob Gibson+ (27) | 204 | 1963 | R | |
| Roy Halladay (26) | 204 | 2003 | R | |
| Randy Johnson (30) | 204 | 1994 | L | |
| Mark Langston (23) | 204 | 1984 | L | |
| Greg Maddux (32) | 204 | 1998 | R | |
| Mike Mussina (27) | 204 | 1996 | R | |
| Shane Reynolds (28) | 204 | 1996 | R | |
| Todd Stottlemyre (33) | 204 | 1998 | R | |
| Gus Weyhing (21) | 204 | 1888 | R | |
| 471. | A.J. Burnett (25) | 203 | 2002 | R |
| Mike Cuellar (30) | 203 | 1967 | L | |
| Turk Farrell (28) | 203 | 1962 | R | |
| Walter Johnson+ (27) | 203 | 1915 | R | |
| Bobby Mathews (31) | 203 | 1883 | R | |
| Nolan Ryan+ (44) | 203 | 1991 | R | |
| Curt Schilling (37) | 203 | 2004 | R | |
| 478. | Jeremy Bonderman (23) | 202 | 2006 | R |
| Elton Chamberlain (21) | 202 | 1889 | R | |
| Joe Coleman (26) | 202 | 1973 | R | |
| Charlie Getzien (24) | 202 | 1888 | R | |
| Ken Holtzman (24) | 202 | 1970 | L | |
| Mickey Lolich (33) | 202 | 1974 | L | |
| Kirk McCaskill (25) | 202 | 1986 | R | |
| Dave McNally (25) | 202 | 1968 | L | |
| Camilo Pascual (29) | 202 | 1963 | R | |
| Jack Powell (29) | 202 | 1904 | R | |
| Chris Short (30) | 202 | 1968 | L | |
| Johnny Vander Meer (26) | 202 | 1941 | L | |
| Gus Weyhing (25) | 202 | 1892 | R | |
| Floyd Youmans (22) | 202 | 1986 | R | |
| Carlos Zambrano (24) | 202 | 2005 | R | |
| 493. | Chad Billingsley (23) | 201 | 2008 | R |
| Jim Bunning+ (27) | 201 | 1959 | R | |
| Jim Bunning+ (28) | 201 | 1960 | R | |
| Bartolo Colon (28) | 201 | 2001 | R | |
| Jose DeLeon (28) | 201 | 1989 | R | |
| Ron Guidry (28) | 201 | 1979 | L | |
| Daisuke Matsuzaka (26) | 201 | 2007 | R | |
| Gaylord Perry+ (27) | 201 | 1966 | R | |
| Rank | Player (age that year) | Strikeouts | Year | Throws |
| Eddie Plank+ (28) | 201 | 1904 | L | |
| Charley Radbourn+ (27) | 201 | 1882 | R | |
| Nap Rucker (24) | 201 | 1909 | L | |
| Amos Rusie+ (24) | 201 | 1895 | R | |
| Tom Seaver+ (29) | 201 | 1974 | R | |
| Don Sutton+ (25) | 201 | 1970 | R |
Note that seasons prior to 1876 are not included in single-season marks, but are included in career marks.
