+ - Indicates Hall of Famer. Bold indicates active player.
Statistic Description: Strikeouts
| Rank | Player (yrs, age) | Strikeouts | Bats |
|---|---|---|---|
| 1. | Adam Dunn (13, 33) | 2079 | L |
| 2. | Alex Rodriguez (19, 37) | 2032 | R |
| 3. | Derek Jeter (18, 39) | 1743 | R |
| 4. | Alfonso Soriano (15, 37) | 1608 | R |
| 5. | Carlos Pena (13, 35) | 1516 | L |
| 6. | Jason Giambi (19, 42) | 1515 | L |
| 7. | Torii Hunter (17, 37) | 1458 | R |
| 8. | David Ortiz (17, 37) | 1398 | L |
| 9. | Carlos Beltran (16, 36) | 1361 | B |
| 10. | Ryan Howard (10, 33) | 1350 | L |
| 11. | Adrian Beltre (16, 34) | 1317 | R |
| 12. | Paul Konerko (17, 37) | 1292 | R |
| 13. | Brandon Inge (13, 36) | 1285 | R |
| 14. | Lance Berkman (15, 37) | 1268 | B |
| 15. | Raul Ibanez (18, 41) | 1204 | L |
| 16. | Jason Bay (11, 34) | 1178 | R |
| 17. | Michael Young (14, 36) | 1176 | R |
| 18. | Mark Reynolds (7, 29) | 1159 | R |
| 19. | Alex Gonzalez (15, 36) | 1154 | R |
| 20. | Dan Uggla (8, 33) | 1136 | R |
| 21. | Miguel Cabrera (11, 30) | 1128 | R |
| 22. | Mark Teixeira (10, 33) | 1123 | B |
| 23. | Curtis Granderson (10, 32) | 1099 | L |
| Nick Swisher (10, 32) | 1099 | B | |
| 25. | Todd Helton (17, 39) | 1098 | L |
| 26. | Jhonny Peralta (11, 31) | 1090 | R |
| 27. | Adam LaRoche (10, 33) | 1076 | L |
| 28. | B.J. Upton (9, 28) | 1067 | R |
| 29. | Miguel Tejada (16, 39) | 1060 | R |
| 30. | Aramis Ramirez (16, 35) | 1049 | R |
| 31. | Miguel Olivo (12, 34) | 1040 | R |
| 32. | David Wright (10, 30) | 1033 | R |
| 33. | Eric Chavez (16, 35) | 1030 | L |
| 34. | Jimmy Rollins (14, 34) | 980 | B |
| 35. | Bill Hall (11, 33) | 971 | R |
| 36. | Rickie Weeks (10, 30) | 967 | R |
| 37. | Jayson Werth (11, 34) | 965 | R |
| 38. | Lyle Overbay (13, 36) | 959 | L |
| 39. | Juan Uribe (13, 33) | 948 | R |
| 40. | Matt Holliday (10, 33) | 944 | R |
| 41. | Eric Hinske (12, 35) | 939 | L |
| 42. | Corey Patterson (12, 33) | 933 | L |
| 43. | Travis Hafner (12, 36) | 924 | L |
| 44. | Carl Crawford (12, 31) | 913 | L |
| 45. | Michael Cuddyer (13, 34) | 908 | R |
| 46. | Adrian Gonzalez (10, 31) | 905 | L |
| 47. | Rafael Furcal (13, 35) | 903 | B |
| Vernon Wells (15, 34) | 903 | R | |
| 49. | Austin Kearns (12, 33) | 898 | R |
| 50. | Prince Fielder (9, 29) | 896 | L |
| Rank | Player (yrs, age) | Strikeouts | Bats |
| 51. | Ty Wigginton (12, 35) | 882 | R |
| 52. | Matt Kemp (8, 28) | 881 | R |
| 53. | Jeff Francoeur (9, 29) | 875 | R |
| 54. | Alex Rios (10, 32) | 873 | R |
| 55. | John Buck (10, 32) | 864 | R |
| 56. | Kelly Johnson (8, 31) | 862 | L |
| 57. | Jonny Gomes (11, 32) | 851 | R |
| 58. | Josh Willingham (10, 34) | 844 | R |
| 59. | Chris Young (8, 29) | 834 | R |
| 60. | Ichiro Suzuki (13, 39) | 830 | L |
| 61. | Kevin Youkilis (10, 34) | 815 | R |
| 62. | Albert Pujols (13, 33) | 801 | R |
| 63. | Brad Hawpe (8, 34) | 796 | L |
| 64. | Chase Utley (11, 34) | 780 | L |
| 65. | Corey Hart (9, 31) | 775 | R |
| 66. | Ryan Ludwick (11, 34) | 765 | R |
| 67. | Justin Morneau (11, 32) | 763 | L |
| 68. | Ryan Zimmerman (9, 28) | 758 | R |
| 69. | Marlon Byrd (12, 35) | 753 | R |
| 70. | Jose Bautista (10, 32) | 750 | R |
| 71. | Brian Roberts (13, 35) | 747 | B |
| 72. | Hanley Ramirez (9, 29) | 741 | R |
| 73. | Mark Kotsay (17, 37) | 740 | L |
| 74. | Justin Upton (7, 25) | 736 | R |
| 75. | Hunter Pence (7, 30) | 735 | R |
| 76. | Ramon Hernandez (15, 37) | 731 | R |
| 77. | Brandon Phillips (12, 32) | 730 | R |
| 78. | Mike Napoli (8, 31) | 726 | R |
| 79. | Ryan Braun (7, 29) | 722 | R |
| 80. | A.J. Pierzynski (16, 36) | 716 | L |
| 81. | Cody Ross (10, 32) | 713 | R |
| 82. | Andre Ethier (8, 31) | 704 | L |
| 83. | Mark Ellis (11, 36) | 703 | R |
| 84. | Jason Kubel (9, 31) | 701 | L |
| 85. | Michael Bourn (8, 30) | 695 | L |
| 86. | Jay Bruce (6, 26) | 686 | L |
| 87. | David DeJesus (11, 33) | 682 | L |
| 88. | Mark Teahen (7, 31) | 679 | L |
| 89. | Alex Gordon (7, 29) | 676 | L |
| 90. | Mark DeRosa (16, 38) | 669 | R |
| 91. | Shin-Soo Choo (9, 30) | 668 | L |
| 92. | Reed Johnson (11, 36) | 665 | R |
| 93. | Josh Hamilton (7, 32) | 664 | L |
| 94. | Chase Headley (7, 29) | 655 | B |
| 95. | Edwin Encarnacion (9, 30) | 650 | R |
| 96. | Coco Crisp (12, 33) | 638 | B |
| 97. | Nelson Cruz (9, 32) | 636 | R |
| Adam Jones (8, 27) | 636 | R | |
| 99. | Delmon Young (8, 27) | 633 | R |
| 100. | Stephen Drew (8, 30) | 632 | L |