+ - Indicates Hall of Famer. Bold indicates active player.
Statistic Description: Strikeouts
| Rank | Player (yrs, age) | Strikeouts | Bats |
|---|---|---|---|
| 1. | Adam Dunn (13, 33) | 2087 | L |
| 2. | Alex Rodriguez (19, 37) | 2032 | R |
| 3. | Derek Jeter (18, 39) | 1743 | R |
| 4. | Alfonso Soriano (15, 37) | 1611 | R |
| 5. | Carlos Pena (13, 35) | 1519 | L |
| 6. | Jason Giambi (19, 42) | 1518 | L |
| 7. | Torii Hunter (17, 37) | 1463 | R |
| 8. | David Ortiz (17, 37) | 1399 | L |
| 9. | Carlos Beltran (16, 36) | 1366 | B |
| 10. | Ryan Howard (10, 33) | 1352 | L |
| 11. | Adrian Beltre (16, 34) | 1319 | R |
| 12. | Paul Konerko (17, 37) | 1296 | R |
| 13. | Brandon Inge (13, 36) | 1287 | R |
| 14. | Lance Berkman (15, 37) | 1271 | B |
| 15. | Raul Ibanez (18, 41) | 1208 | L |
| 16. | Jason Bay (11, 34) | 1181 | R |
| 17. | Michael Young (14, 36) | 1177 | R |
| 18. | Mark Reynolds (7, 29) | 1168 | R |
| 19. | Alex Gonzalez (15, 36) | 1159 | R |
| 20. | Dan Uggla (8, 33) | 1141 | R |
| 21. | Miguel Cabrera (11, 30) | 1131 | R |
| 22. | Mark Teixeira (10, 33) | 1123 | B |
| 23. | Nick Swisher (10, 32) | 1105 | B |
| 24. | Curtis Granderson (10, 32) | 1103 | L |
| Todd Helton (17, 39) | 1103 | L | |
| 26. | Jhonny Peralta (11, 31) | 1096 | R |
| 27. | Adam LaRoche (10, 33) | 1084 | L |
| 28. | B.J. Upton (9, 28) | 1075 | R |
| 29. | Miguel Tejada (16, 39) | 1061 | R |
| 30. | Aramis Ramirez (16, 35) | 1052 | R |
| 31. | David Wright (10, 30) | 1041 | R |
| 32. | Miguel Olivo (12, 34) | 1040 | R |
| 33. | Eric Chavez (16, 35) | 1032 | L |
| 34. | Jimmy Rollins (14, 34) | 982 | B |
| 35. | Rickie Weeks (10, 30) | 975 | R |
| 36. | Bill Hall (11, 33) | 971 | R |
| 37. | Jayson Werth (11, 34) | 965 | R |
| 38. | Lyle Overbay (13, 36) | 963 | L |
| 39. | Juan Uribe (13, 33) | 953 | R |
| 40. | Matt Holliday (10, 33) | 947 | R |
| 41. | Eric Hinske (12, 35) | 940 | L |
| 42. | Corey Patterson (12, 33) | 933 | L |
| 43. | Travis Hafner (12, 36) | 926 | L |
| 44. | Carl Crawford (12, 31) | 916 | L |
| 45. | Adrian Gonzalez (10, 31) | 912 | L |
| 46. | Michael Cuddyer (13, 34) | 908 | R |
| 47. | Vernon Wells (15, 34) | 907 | R |
| 48. | Prince Fielder (9, 29) | 903 | L |
| Rafael Furcal (13, 35) | 903 | B | |
| 50. | Austin Kearns (12, 33) | 898 | R |
| Rank | Player (yrs, age) | Strikeouts | Bats |
| 51. | Matt Kemp (8, 28) | 891 | R |
| 52. | Ty Wigginton (12, 35) | 883 | R |
| 53. | Jeff Francoeur (9, 29) | 878 | R |
| 54. | Alex Rios (10, 32) | 877 | R |
| 55. | John Buck (10, 32) | 869 | R |
| 56. | Kelly Johnson (8, 31) | 864 | L |
| 57. | Jonny Gomes (11, 32) | 853 | R |
| 58. | Josh Willingham (10, 34) | 850 | R |
| 59. | Chris Young (8, 29) | 839 | R |
| 60. | Ichiro Suzuki (13, 39) | 832 | L |
| 61. | Kevin Youkilis (10, 34) | 815 | R |
| 62. | Albert Pujols (13, 33) | 807 | R |
| 63. | Brad Hawpe (8, 34) | 796 | L |
| 64. | Chase Utley (11, 34) | 783 | L |
| 65. | Corey Hart (9, 31) | 775 | R |
| 66. | Ryan Ludwick (11, 34) | 765 | R |
| Justin Morneau (11, 32) | 765 | L | |
| 68. | Ryan Zimmerman (9, 28) | 764 | R |
| 69. | Marlon Byrd (12, 35) | 756 | R |
| 70. | Jose Bautista (10, 32) | 755 | R |
| 71. | Brian Roberts (13, 35) | 747 | B |
| 72. | Justin Upton (7, 25) | 743 | R |
| 73. | Hanley Ramirez (9, 29) | 741 | R |
| 74. | Mark Kotsay (17, 37) | 740 | L |
| 75. | Hunter Pence (7, 30) | 738 | R |
| 76. | Mike Napoli (8, 31) | 735 | R |
| Brandon Phillips (12, 32) | 735 | R | |
| 78. | Ramon Hernandez (15, 37) | 731 | R |
| 79. | Ryan Braun (7, 29) | 726 | R |
| 80. | A.J. Pierzynski (16, 36) | 717 | L |
| 81. | Cody Ross (10, 32) | 716 | R |
| 82. | Andre Ethier (8, 31) | 711 | L |
| 83. | Mark Ellis (11, 36) | 705 | R |
| 84. | Jason Kubel (9, 31) | 701 | L |
| 85. | Michael Bourn (8, 30) | 698 | L |
| 86. | Jay Bruce (6, 26) | 694 | L |
| 87. | David DeJesus (11, 33) | 685 | L |
| 88. | Alex Gordon (7, 29) | 680 | L |
| 89. | Mark Teahen (7, 31) | 679 | L |
| 90. | Shin-Soo Choo (9, 30) | 675 | L |
| 91. | Mark DeRosa (16, 38) | 670 | R |
| Josh Hamilton (7, 32) | 670 | L | |
| 93. | Reed Johnson (11, 36) | 665 | R |
| 94. | Chase Headley (7, 29) | 660 | B |
| 95. | Edwin Encarnacion (9, 30) | 653 | R |
| 96. | Nelson Cruz (9, 32) | 643 | R |
| 97. | Coco Crisp (12, 33) | 642 | B |
| 98. | Adam Jones (8, 27) | 641 | R |
| 99. | Delmon Young (8, 27) | 639 | R |
| 100. | Stephen Drew (8, 30) | 637 | L |