+ - Indicates Hall of Famer. Bold indicates active player.
| Rank | Player (yrs, age) | Runs Scored | Bats |
|---|---|---|---|
| 1. | Alex Rodriguez (18, 35) | 1824 | R |
| 2. | Derek Jeter (17, 37) | 1769 | R |
| 3. | Johnny Damon (17, 37) | 1643 | L |
| 4. | Jim Thome (21, 40) | 1566 | L |
| 5. | Chipper Jones (18, 39) | 1561 | B |
| 6. | Manny Ramirez (19, 39) | 1544 | R |
| 7. | Omar Vizquel (23, 44) | 1432 | B |
| 8. | Bobby Abreu (16, 37) | 1412 | L |
| 9. | Ivan Rodriguez (21, 39) | 1354 | R |
| 10. | Todd Helton (15, 37) | 1329 | L |
| 11. | Vladimir Guerrero (16, 36) | 1328 | R |
| 12. | Albert Pujols (11, 31) | 1291 | R |
| 13. | Miguel Tejada (15, 37) | 1215 | R |
| 14. | Edgar Renteria (16, 34) | 1200 | R |
| 15. | Jason Giambi (17, 40) | 1196 | L |
| 16. | Scott Rolen (16, 36) | 1185 | R |
| 17. | Carlos Beltran (14, 34) | 1184 | B |
| 18. | Andruw Jones (16, 34) | 1177 | R |
| 19. | Ichiro Suzuki (11, 37) | 1127 | L |
| 20. | Lance Berkman (13, 35) | 1107 | B |
| 21. | Derrek Lee (15, 35) | 1081 | R |
| 22. | Jimmy Rollins (12, 32) | 1080 | B |
| 23. | Magglio Ordonez (15, 37) | 1076 | R |
| 24. | Carlos Lee (13, 35) | 1072 | R |
| 25. | Mike Cameron (17, 38) | 1064 | R |
| 26. | David Ortiz (15, 35) | 1059 | L |
| 27. | Paul Konerko (15, 35) | 1040 | R |
| 28. | Michael Young (12, 34) | 1006 | R |
| 29. | Adrian Beltre (14, 32) | 994 | R |
| 30. | Rafael Furcal (12, 33) | 990 | B |
| 31. | Torii Hunter (15, 35) | 987 | R |
| 32. | Orlando Cabrera (15, 36) | 985 | R |
| 33. | Juan Pierre (12, 33) | 980 | L |
| 34. | Alfonso Soriano (13, 35) | 978 | R |
| 35. | Placido Polanco (14, 35) | 948 | R |
| 36. | J.D. Drew (14, 35) | 944 | L |
| 37. | Raul Ibanez (16, 39) | 928 | L |
| 38. | Adam Dunn (11, 31) | 901 | L |
| 39. | Jorge Posada (17, 39) | 900 | B |
| 40. | Aramis Ramirez (14, 33) | 873 | R |
| 41. | Mark Teixeira (9, 31) | 872 | B |
| 42. | Miguel Cabrera (9, 28) | 852 | R |
| 43. | Vernon Wells (13, 32) | 849 | R |
| 44. | Carl Crawford (10, 29) | 830 | L |
| 45. | Aubrey Huff (12, 34) | 799 | L |
| 46. | Melvin Mora (13, 39) | 794 | R |
| 47. | Brian Roberts (11, 33) | 775 | B |
| 48. | Mark Kotsay (15, 35) | 773 | L |
| 49. | Matt Stairs (19, 43) | 770 | L |
| 50. | Pat Burrell (12, 34) | 767 | R |
| Rank | Player (yrs, age) | Runs Scored | Bats |
| 51. | Matt Holliday (8, 31) | 751 | R |
| 52. | Eric Chavez (14, 33) | 746 | L |
| 53. | Jose Reyes (9, 28) | 735 | B |
| 54. | Carlos Guillen (14, 35) | 733 | B |
| 55. | Chase Utley (9, 32) | 731 | L |
| 56. | David Wright (8, 28) | 699 | R |
| 57. | Julio Lugo (12, 35) | 688 | R |
| 58. | Jason Bay (9, 32) | 686 | R |
| 59. | Ronnie Belliard (13, 36) | 685 | R |
| 60. | Chone Figgins (10, 33) | 682 | B |
| 61. | Jason Varitek (15, 39) | 664 | B |
| 62. | Adam Kennedy (13, 35) | 660 | L |
| 63. | Hideki Matsui (9, 37) | 649 | L |
| 64. | Craig Counsell (16, 40) | 647 | L |
| Curtis Granderson (8, 30) | 647 | L | |
| 66. | Casey Blake (13, 37) | 644 | R |
| 67. | Alex Gonzalez (13, 34) | 641 | R |
| 68. | Ryan Howard (8, 31) | 633 | L |
| 69. | Carlos Pena (11, 33) | 631 | L |
| 70. | Orlando Hudson (10, 33) | 627 | B |
| 71. | Hanley Ramirez (7, 27) | 617 | R |
| 72. | Alex Rios (8, 30) | 615 | R |
| 73. | Robinson Cano (7, 28) | 613 | L |
| A.J. Pierzynski (14, 34) | 613 | L | |
| Aaron Rowand (11, 33) | 613 | R | |
| 76. | Nick Swisher (8, 30) | 609 | B |
| 77. | Michael Cuddyer (11, 32) | 606 | R |
| 78. | Grady Sizemore (8, 28) | 601 | L |
| 79. | Felipe Lopez (11, 31) | 600 | B |
| 80. | Adrian Gonzalez (8, 29) | 596 | L |
| 81. | Dan Uggla (6, 31) | 587 | R |
| 82. | Victor Martinez (10, 32) | 585 | B |
| 83. | Coco Crisp (10, 31) | 583 | B |
| 84. | Prince Fielder (7, 27) | 571 | L |
| Corey Patterson (12, 31) | 571 | L | |
| 86. | Kevin Youkilis (8, 32) | 569 | R |
| 87. | Jhonny Peralta (9, 29) | 568 | R |
| 88. | Mark Ellis (9, 34) | 567 | R |
| Brandon Phillips (10, 30) | 567 | R | |
| Juan Uribe (11, 31) | 567 | R | |
| 91. | Lyle Overbay (11, 34) | 566 | L |
| 92. | Travis Hafner (10, 34) | 565 | L |
| 93. | David DeJesus (9, 31) | 561 | L |
| Jack Wilson (11, 33) | 561 | R | |
| 95. | Ramon Hernandez (13, 35) | 560 | R |
| 96. | Ian Kinsler (6, 29) | 558 | R |
| 97. | Justin Morneau (9, 30) | 550 | L |
| 98. | Joe Mauer (8, 28) | 545 | L |
| 99. | Jerry Hairston (14, 35) | 544 | R |
| Scott Podsednik (10, 35) | 544 | L | |
| Rank | Player (yrs, age) | Runs Scored | Bats |
| Shane Victorino (8, 30) | 544 | B |