+ - Indicates Hall of Famer. Bold indicates active player.
| Rank | Player (yrs, age) | Runs Created | Bats |
|---|---|---|---|
| 1. | Alex Rodriguez (18, 35) | 2065 | R |
| 2. | Manny Ramirez (19, 39) | 2005 | R |
| 3. | Jim Thome (21, 40) | 1967 | L |
| 4. | Chipper Jones (18, 39) | 1899 | B |
| 5. | Todd Helton (15, 37) | 1759 | L |
| 6. | Derek Jeter (17, 37) | 1748 | R |
| 7. | Bobby Abreu (16, 37) | 1663 | L |
| 8. | Vladimir Guerrero (16, 36) | 1626 | R |
| 9. | Albert Pujols (11, 31) | 1613 | R |
| 10. | Jason Giambi (17, 40) | 1579 | L |
| 11. | Johnny Damon (17, 37) | 1566 | L |
| 12. | Lance Berkman (13, 35) | 1429 | B |
| 13. | Ivan Rodriguez (21, 39) | 1398 | R |
| 14. | Scott Rolen (16, 36) | 1332 | R |
| 15. | Omar Vizquel (23, 44) | 1313 | B |
| 16. | David Ortiz (15, 35) | 1310 | L |
| 17. | Carlos Beltran (14, 34) | 1282 | B |
| 18. | Paul Konerko (15, 35) | 1272 | R |
| 19. | Derrek Lee (15, 35) | 1268 | R |
| 20. | Magglio Ordonez (15, 37) | 1251 | R |
| 21. | Ichiro Suzuki (11, 37) | 1227 | L |
| 22. | Andruw Jones (16, 34) | 1225 | R |
| 23. | Miguel Tejada (15, 37) | 1222 | R |
| 24. | Carlos Lee (13, 35) | 1219 | R |
| 25. | Adrian Beltre (14, 32) | 1116 | R |
| 26. | Edgar Renteria (16, 34) | 1112 | R |
| 27. | Jorge Posada (17, 39) | 1100 | B |
| 28. | Mike Cameron (17, 38) | 1093 | R |
| 29. | Adam Dunn (11, 31) | 1089 | L |
| 30. | Miguel Cabrera (9, 28) | 1087 | R |
| 31. | Aramis Ramirez (14, 33) | 1063 | R |
| 32. | Mark Teixeira (9, 31) | 1056 | B |
| 33. | Michael Young (12, 34) | 1054 | R |
| 34. | Alfonso Soriano (13, 35) | 1052 | R |
| 35. | J.D. Drew (14, 35) | 1040 | L |
| 36. | Jimmy Rollins (12, 32) | 1026 | B |
| 37. | Raul Ibanez (16, 39) | 1023 | L |
| 38. | Pat Burrell (12, 34) | 988 | R |
| Torii Hunter (15, 35) | 988 | R | |
| 40. | Aubrey Huff (12, 34) | 955 | L |
| 41. | Orlando Cabrera (15, 36) | 938 | R |
| 42. | Matt Stairs (19, 43) | 907 | L |
| 43. | Placido Polanco (14, 35) | 906 | R |
| 44. | Juan Pierre (12, 33) | 904 | L |
| 45. | Rafael Furcal (12, 33) | 899 | B |
| 46. | Matt Holliday (8, 31) | 894 | R |
| 47. | Vernon Wells (13, 32) | 888 | R |
| 48. | Carl Crawford (10, 29) | 848 | L |
| 49. | Melvin Mora (13, 39) | 844 | R |
| 50. | Chase Utley (9, 32) | 841 | L |
| Rank | Player (yrs, age) | Runs Created | Bats |
| 51. | Mark Kotsay (15, 35) | 836 | L |
| 52. | David Wright (8, 28) | 825 | R |
| 53. | Eric Chavez (14, 33) | 813 | L |
| 54. | Ryan Howard (8, 31) | 799 | L |
| 55. | Jason Bay (9, 32) | 796 | R |
| 56. | Brian Roberts (11, 33) | 775 | B |
| 57. | Jason Varitek (15, 39) | 767 | B |
| 58. | Prince Fielder (7, 27) | 763 | L |
| 59. | Hideki Matsui (9, 37) | 753 | L |
| Carlos Pena (11, 33) | 753 | L | |
| 61. | Carlos Guillen (14, 35) | 738 | B |
| 62. | Travis Hafner (10, 34) | 733 | L |
| 63. | Victor Martinez (10, 32) | 728 | B |
| 64. | Adrian Gonzalez (8, 29) | 721 | L |
| 65. | Ronnie Belliard (13, 36) | 709 | R |
| 66. | Jose Reyes (9, 28) | 706 | B |
| 67. | A.J. Pierzynski (14, 34) | 681 | L |
| 68. | Adam Kennedy (13, 35) | 680 | L |
| 69. | Lyle Overbay (11, 34) | 673 | L |
| 70. | Ramon Hernandez (13, 35) | 669 | R |
| 71. | Casey Blake (13, 37) | 667 | R |
| 72. | Robinson Cano (7, 28) | 665 | L |
| Justin Morneau (9, 30) | 665 | L | |
| 74. | Hanley Ramirez (7, 27) | 663 | R |
| 75. | Orlando Hudson (10, 33) | 658 | B |
| 76. | Joe Mauer (8, 28) | 653 | L |
| Kevin Youkilis (8, 32) | 653 | R | |
| 78. | Curtis Granderson (8, 30) | 650 | L |
| 79. | Julio Lugo (12, 35) | 641 | R |
| Nick Swisher (8, 30) | 641 | B | |
| 81. | Grady Sizemore (8, 28) | 636 | L |
| 82. | Chone Figgins (10, 33) | 631 | B |
| 83. | Alex Gonzalez (13, 34) | 627 | R |
| 84. | Aaron Rowand (11, 33) | 622 | R |
| 85. | Michael Cuddyer (11, 32) | 616 | R |
| 86. | Nick Markakis (6, 27) | 605 | L |
| 87. | Ryan Braun (5, 27) | 604 | R |
| 88. | Dan Uggla (6, 31) | 602 | R |
| 89. | Craig Counsell (16, 40) | 601 | L |
| 90. | Milton Bradley (12, 33) | 600 | B |
| 91. | Alex Rios (8, 30) | 594 | R |
| 92. | Felipe Lopez (11, 31) | 591 | B |
| 93. | Jhonny Peralta (9, 29) | 580 | R |
| 94. | Adam LaRoche (8, 31) | 577 | L |
| 95. | David DeJesus (9, 31) | 575 | L |
| Ty Wigginton (10, 33) | 575 | R | |
| 97. | Juan Uribe (11, 31) | 568 | R |
| 98. | Jayson Werth (9, 32) | 556 | R |
| 99. | Brandon Inge (11, 34) | 555 | R |
| 100. | Mark Ellis (9, 34) | 551 | R |