+ - Indicates Hall of Famer. Bold indicates active player.
Statistic Description: Losses
| Rank | Player (yrs, age) | Losses | Throws |
|---|---|---|---|
| 1. | Derek Lowe (17, 40) | 157 | R |
| 2. | Andy Pettitte (18, 41) | 144 | L |
| 3. | Mark Buehrle (14, 34) | 134 | L |
| Barry Zito (14, 35) | 134 | L | |
| 5. | Ryan Dempster (16, 36) | 128 | R |
| 6. | A.J. Burnett (15, 36) | 125 | R |
| Jamey Wright (18, 38) | 125 | R | |
| 8. | Bartolo Colon (16, 40) | 124 | R |
| 9. | Jon Garland (13, 33) | 122 | R |
| 10. | Bronson Arroyo (14, 36) | 119 | R |
| 11. | Miguel Batista (18, 42) | 115 | R |
| 12. | Esteban Loaiza (14, 41) | 114 | R |
| 13. | Kyle Lohse (13, 34) | 113 | R |
| 14. | Ted Lilly (15, 37) | 112 | L |
| 15. | Jason Marquis (14, 34) | 111 | R |
| 16. | Aaron Harang (12, 35) | 108 | R |
| 17. | Tim Hudson (15, 37) | 106 | R |
| 18. | CC Sabathia (13, 32) | 105 | L |
| 19. | Roy Halladay (16, 36) | 104 | R |
| 20. | Kip Wells (12, 36) | 103 | R |
| 21. | Freddy Garcia (15, 36) | 102 | R |
| 22. | Dan Haren (11, 32) | 101 | R |
| 23. | Josh Beckett (13, 33) | 100 | R |
| 24. | John Lackey (11, 34) | 98 | R |
| 25. | Brett Myers (12, 32) | 96 | R |
| Jake Westbrook (13, 35) | 96 | R | |
| 27. | Darren Oliver (20, 42) | 95 | L |
| 28. | Chris Carpenter (15, 38) | 94 | R |
| Jake Peavy (12, 32) | 94 | R | |
| 30. | Kelvim Escobar (12, 37) | 91 | R |
| 31. | Wandy Rodriguez (9, 34) | 90 | L |
| 32. | Rodrigo Lopez (11, 37) | 89 | R |
| 33. | LaTroy Hawkins (19, 40) | 88 | R |
| Paul Maholm (9, 31) | 88 | L | |
| 35. | Ramon Ortiz (12, 40) | 85 | R |
| 36. | Joe Blanton (10, 32) | 82 | R |
| Ervin Santana (9, 30) | 82 | R | |
| 38. | Matt Cain (9, 28) | 80 | R |
| Cliff Lee (12, 34) | 80 | L | |
| 40. | Aaron Cook (11, 34) | 79 | R |
| 41. | Chris Capuano (9, 34) | 78 | L |
| Zack Greinke (10, 29) | 78 | R | |
| Jeremy Guthrie (10, 34) | 78 | R | |
| Felix Hernandez (9, 27) | 78 | R | |
| Johan Santana (12, 34) | 78 | L | |
| 46. | Jeremy Bonderman (8, 30) | 77 | R |
| Nate Robertson (9, 35) | 77 | L | |
| 48. | Jeff Francis (9, 32) | 76 | L |
| Edwin Jackson (11, 29) | 76 | R | |
| James Shields (8, 31) | 76 | R | |
| Rank | Player (yrs, age) | Losses | Throws |
| 51. | Zach Duke (9, 30) | 74 | L |
| Mark Hendrickson (10, 39) | 74 | L | |
| 53. | Roberto Hernandez (8, 32) | 73 | R |
| 54. | Bruce Chen (15, 36) | 72 | L |
| Oliver Perez (11, 31) | 72 | L | |
| 56. | Gavin Floyd (10, 30) | 70 | R |
| 57. | Dave Bush (9, 33) | 69 | R |
| Ricky Nolasco (8, 30) | 69 | R | |
| Joe Saunders (9, 32) | 69 | L | |
| 60. | Kevin Correia (11, 32) | 68 | R |
| Ubaldo Jimenez (8, 29) | 68 | R | |
| Justin Verlander (9, 30) | 68 | R | |
| 63. | Jose Contreras (11, 41) | 67 | R |
| 64. | Erik Bedard (10, 34) | 66 | L |
| 65. | Cole Hamels (8, 29) | 65 | L |
| 66. | Scott Kazmir (9, 29) | 63 | L |
| 67. | Kyle Farnsworth (15, 37) | 62 | R |
| 68. | Chad Billingsley (8, 28) | 61 | R |
| R.A. Dickey (11, 38) | 61 | R | |
| Matt Garza (7, 29) | 61 | R | |
| 71. | John Danks (6, 28) | 60 | L |
| 72. | Luke Hochevar (7, 29) | 59 | R |
| Hiroki Kuroda (6, 38) | 59 | R | |
| 74. | Tim Lincecum (7, 29) | 58 | R |
| Mariano Rivera (19, 43) | 58 | R | |
| Jonathan Sanchez (8, 30) | 58 | L | |
| 77. | Mike Pelfrey (8, 29) | 57 | R |
| Tim Redding (8, 35) | 57 | R | |
| 79. | Justin Masterson (6, 28) | 55 | R |
| 80. | Francisco Liriano (8, 29) | 54 | L |
| Jorge De La Rosa (10, 32) | 54 | L | |
| Anibal Sanchez (8, 29) | 54 | R | |
| 83. | John Lannan (7, 28) | 53 | L |
| Jason Vargas (8, 30) | 53 | L | |
| Jered Weaver (8, 30) | 53 | R | |
| 86. | Jason Hammel (8, 30) | 52 | R |
| 87. | Trevor Cahill (5, 25) | 51 | R |
| Chris Volstad (6, 26) | 51 | R | |
| 89. | Octavio Dotel (15, 39) | 50 | R |
| Adam Wainwright (8, 31) | 50 | R | |
| 91. | Scott Baker (7, 31) | 48 | R |
| Jon Lester (8, 29) | 48 | L | |
| 93. | Luis Ayala (9, 35) | 47 | R |
| Chad Durbin (14, 35) | 47 | R | |
| Scott Feldman (9, 30) | 47 | R | |
| C.J. Wilson (9, 32) | 47 | L | |
| 97. | Johnny Cueto (6, 27) | 46 | R |
| Brandon Lyon (12, 33) | 46 | R | |
| Clayton Richard (6, 29) | 46 | L | |
| 100. | Yovani Gallardo (7, 27) | 45 | R |
| Rank | Player (yrs, age) | Losses | Throws |
| Tom Gorzelanny (9, 30) | 45 | L | |
| Sean Marshall (8, 30) | 45 | L | |
| Charlie Morton (5, 29) | 45 | R | |
| Ricky Romero (5, 28) | 45 | L |