+ - Indicates Hall of Famer. Bold indicates active player.
Statistic Description: Losses
| Rank | Player (yrs, age) | Losses | Throws |
|---|---|---|---|
| 1. | Derek Lowe (17, 40) | 157 | R |
| 2. | Andy Pettitte (18, 41) | 145 | L |
| 3. | Mark Buehrle (14, 34) | 135 | L |
| Barry Zito (14, 35) | 135 | L | |
| 5. | Ryan Dempster (16, 36) | 129 | R |
| 6. | A.J. Burnett (15, 36) | 126 | R |
| 7. | Jamey Wright (18, 38) | 125 | R |
| 8. | Bartolo Colon (16, 40) | 124 | R |
| Jon Garland (13, 33) | 124 | R | |
| 10. | Bronson Arroyo (14, 36) | 119 | R |
| 11. | Miguel Batista (18, 42) | 115 | R |
| 12. | Esteban Loaiza (14, 41) | 114 | R |
| Kyle Lohse (13, 34) | 114 | R | |
| 14. | Ted Lilly (15, 37) | 112 | L |
| 15. | Jason Marquis (14, 34) | 111 | R |
| 16. | Aaron Harang (12, 35) | 109 | R |
| 17. | Tim Hudson (15, 37) | 107 | R |
| 18. | CC Sabathia (13, 32) | 105 | L |
| Ismael Valdez (12, 39) | 105 | R | |
| 20. | Roy Halladay (16, 36) | 104 | R |
| 21. | Freddy Garcia (15, 36) | 103 | R |
| Kip Wells (12, 36) | 103 | R | |
| 23. | Dan Haren (11, 32) | 102 | R |
| 24. | Josh Beckett (13, 33) | 100 | R |
| 25. | John Lackey (11, 34) | 98 | R |
| 26. | Brett Myers (12, 32) | 96 | R |
| Roy Oswalt (12, 35) | 96 | R | |
| Jake Westbrook (13, 35) | 96 | R | |
| 29. | Darren Oliver (20, 42) | 95 | L |
| Jake Peavy (12, 32) | 95 | R | |
| 31. | Chris Carpenter (15, 38) | 94 | R |
| 32. | Kelvim Escobar (12, 37) | 91 | R |
| 33. | Wandy Rodriguez (9, 34) | 90 | L |
| 34. | Rodrigo Lopez (11, 37) | 89 | R |
| 35. | LaTroy Hawkins (19, 40) | 88 | R |
| Paul Maholm (9, 31) | 88 | L | |
| 37. | Ramon Ortiz (12, 40) | 86 | R |
| 38. | Ervin Santana (9, 30) | 84 | R |
| 39. | Joe Blanton (10, 32) | 82 | R |
| 40. | Matt Cain (9, 28) | 80 | R |
| Cliff Lee (12, 34) | 80 | L | |
| 42. | Chris Capuano (9, 34) | 79 | L |
| Aaron Cook (11, 34) | 79 | R | |
| Zack Greinke (10, 29) | 79 | R | |
| Jeremy Guthrie (10, 34) | 79 | R | |
| Felix Hernandez (9, 27) | 79 | R | |
| 47. | Edwin Jackson (11, 29) | 78 | R |
| Johan Santana (12, 34) | 78 | L | |
| James Shields (8, 31) | 78 | R | |
| 50. | Jeremy Bonderman (8, 30) | 77 | R |
| Rank | Player (yrs, age) | Losses | Throws |
| Nate Robertson (9, 35) | 77 | L | |
| 52. | Jeff Francis (9, 32) | 76 | L |
| 53. | Zach Duke (9, 30) | 75 | L |
| 54. | Roberto Hernandez (8, 32) | 74 | R |
| Mark Hendrickson (10, 39) | 74 | L | |
| 56. | Oliver Perez (11, 31) | 73 | L |
| 57. | Bruce Chen (15, 36) | 72 | L |
| 58. | Gavin Floyd (10, 30) | 70 | R |
| Joe Saunders (9, 32) | 70 | L | |
| 60. | Dave Bush (9, 33) | 69 | R |
| Kevin Correia (11, 32) | 69 | R | |
| Ubaldo Jimenez (8, 29) | 69 | R | |
| Ricky Nolasco (8, 30) | 69 | R | |
| Justin Verlander (9, 30) | 69 | R | |
| 65. | Jose Contreras (11, 41) | 67 | R |
| Cole Hamels (8, 29) | 67 | L | |
| 67. | Erik Bedard (10, 34) | 66 | L |
| 68. | Kyle Davies (7, 29) | 65 | R |
| 69. | Scott Kazmir (9, 29) | 63 | L |
| 70. | Kyle Farnsworth (15, 37) | 62 | R |
| 71. | Chad Billingsley (8, 28) | 61 | R |
| R.A. Dickey (11, 38) | 61 | R | |
| Matt Garza (8, 29) | 61 | R | |
| 74. | John Danks (7, 28) | 60 | L |
| Luke Hochevar (7, 29) | 60 | R | |
| Hiroki Kuroda (6, 38) | 60 | R | |
| Tim Lincecum (7, 29) | 60 | R | |
| 78. | Mike Pelfrey (8, 29) | 58 | R |
| Mariano Rivera (19, 43) | 58 | R | |
| Jonathan Sanchez (8, 30) | 58 | L | |
| 81. | Tim Redding (8, 35) | 57 | R |
| 82. | Justin Masterson (6, 28) | 56 | R |
| 83. | Anibal Sanchez (8, 29) | 55 | R |
| 84. | Francisco Liriano (8, 29) | 54 | L |
| Jorge De La Rosa (10, 32) | 54 | L | |
| 86. | Jason Hammel (8, 30) | 53 | R |
| John Lannan (7, 28) | 53 | L | |
| Jason Vargas (8, 30) | 53 | L | |
| Jered Weaver (8, 30) | 53 | R | |
| 90. | Trevor Cahill (5, 25) | 52 | R |
| 91. | Chris Volstad (6, 26) | 51 | R |
| Adam Wainwright (8, 31) | 51 | R | |
| 93. | Octavio Dotel (15, 39) | 50 | R |
| 94. | Jon Lester (8, 29) | 49 | L |
| 95. | Scott Baker (7, 31) | 48 | R |
| Scott Feldman (9, 30) | 48 | R | |
| C.J. Wilson (9, 32) | 48 | L | |
| 98. | Luis Ayala (9, 35) | 47 | R |
| Chad Durbin (14, 35) | 47 | R | |
| Yovani Gallardo (7, 27) | 47 | R |