+ - Indicates Hall of Famer. Bold indicates active player.
| Rank | Player (yrs, age) | Losses | Throws |
|---|---|---|---|
| 1. | Tim Wakefield (19, 44) | 180 | R |
| 2. | Livan Hernandez (16, 36) | 176 | R |
| 3. | Javier Vazquez (14, 34) | 160 | R |
| 4. | Derek Lowe (15, 38) | 146 | R |
| 5. | Jeff Suppan (16, 36) | 143 | R |
| 6. | Kevin Millwood (15, 36) | 140 | R |
| 7. | Barry Zito (12, 33) | 124 | L |
| 8. | Jamey Wright (16, 36) | 121 | R |
| 9. | Mark Buehrle (12, 32) | 119 | L |
| Jon Garland (12, 31) | 119 | R | |
| 11. | Ryan Dempster (14, 34) | 116 | R |
| 12. | Bartolo Colon (14, 38) | 113 | R |
| 13. | Miguel Batista (17, 40) | 112 | R |
| 14. | A.J. Burnett (13, 34) | 111 | R |
| 15. | Ted Lilly (13, 35) | 110 | L |
| 16. | Doug Davis (13, 35) | 108 | L |
| 17. | Randy Wolf (13, 34) | 107 | L |
| 18. | Kyle Lohse (11, 32) | 106 | R |
| 19. | Bronson Arroyo (12, 34) | 105 | R |
| 20. | Brett Tomko (14, 38) | 103 | R |
| 21. | Carl Pavano (13, 35) | 102 | R |
| 22. | Brad Penny (12, 33) | 99 | R |
| 23. | Jason Marquis (12, 32) | 98 | R |
| 24. | Tim Hudson (13, 35) | 97 | R |
| 25. | CC Sabathia (11, 30) | 96 | L |
| 26. | Freddy Garcia (13, 34) | 95 | R |
| 27. | Aaron Harang (10, 33) | 94 | R |
| John Lackey (10, 32) | 94 | R | |
| 29. | Roy Oswalt (11, 33) | 93 | R |
| Joel Pineiro (12, 32) | 93 | R | |
| 31. | Chris Carpenter (14, 36) | 92 | R |
| Roy Halladay (14, 34) | 92 | R | |
| 33. | Darren Oliver (18, 40) | 90 | L |
| Vicente Padilla (13, 33) | 90 | R | |
| 35. | Rodrigo Lopez (10, 35) | 88 | R |
| 36. | LaTroy Hawkins (17, 38) | 85 | R |
| Brett Myers (10, 30) | 85 | R | |
| 38. | Dan Haren (9, 30) | 84 | R |
| Ramon Ortiz (11, 38) | 84 | R | |
| Jake Westbrook (11, 33) | 84 | R | |
| 41. | Josh Beckett (11, 31) | 81 | R |
| Jake Peavy (10, 30) | 81 | R | |
| Carlos Zambrano (11, 30) | 81 | R | |
| 44. | Nate Robertson (9, 33) | 77 | L |
| 45. | Ryan Franklin (12, 38) | 76 | R |
| 46. | Wandy Rodriguez (7, 32) | 75 | L |
| 47. | Zach Duke (7, 28) | 74 | L |
| Mark Hendrickson (10, 37) | 74 | L | |
| 49. | Matt Cain (7, 26) | 73 | R |
| Zack Greinke (8, 27) | 73 | R | |
| Rank | Player (yrs, age) | Losses | Throws |
| Paul Maholm (7, 29) | 73 | L | |
| Kerry Wood (13, 34) | 73 | R | |
| 53. | Arthur Rhodes (20, 41) | 70 | L |
| Carlos Silva (9, 32) | 70 | R | |
| 55. | Dave Bush (8, 31) | 69 | R |
| Cliff Lee (10, 32) | 69 | L | |
| Oliver Perez (9, 29) | 69 | L | |
| Johan Santana (11, 32) | 69 | L | |
| Dontrelle Willis (9, 29) | 69 | L | |
| 60. | Aaron Cook (10, 32) | 68 | R |
| 61. | Jose Contreras (9, 39) | 67 | R |
| Felix Hernandez (7, 25) | 67 | R | |
| Ervin Santana (7, 28) | 67 | R | |
| 64. | Fausto Carmona (6, 27) | 66 | R |
| Jeff Francis (7, 30) | 66 | L | |
| 66. | Kyle Davies (7, 27) | 65 | R |
| Jeremy Guthrie (8, 32) | 65 | R | |
| 68. | Chris Capuano (7, 32) | 64 | L |
| Elmer Dessens (14, 40) | 64 | R | |
| 70. | Brian Lawrence (6, 35) | 63 | R |
| James Shields (6, 29) | 63 | R | |
| 72. | Joe Blanton (8, 30) | 62 | R |
| Brandon Webb (7, 32) | 62 | R | |
| 74. | Scott Kazmir (8, 27) | 61 | L |
| 75. | Edwin Jackson (9, 27) | 60 | R |
| 76. | Bruce Chen (13, 34) | 58 | L |
| 77. | Danys Baez (10, 33) | 57 | R |
| Tim Redding (8, 33) | 57 | R | |
| Mariano Rivera (17, 41) | 57 | R | |
| Justin Verlander (7, 28) | 57 | R | |
| 81. | John Danks (5, 26) | 56 | L |
| Kyle Farnsworth (13, 35) | 56 | R | |
| 83. | Gavin Floyd (8, 28) | 55 | R |
| Josh Towers (8, 34) | 55 | R | |
| 85. | Kevin Correia (9, 30) | 54 | R |
| Matt Garza (6, 27) | 54 | R | |
| Cole Hamels (6, 27) | 54 | L | |
| Mike Pelfrey (6, 27) | 54 | R | |
| 89. | Casey Fossum (9, 33) | 53 | L |
| Jason Isringhausen (15, 38) | 53 | R | |
| Ian Snell (7, 29) | 53 | R | |
| Jorge Sosa (9, 33) | 53 | R | |
| 93. | Chad Billingsley (6, 26) | 52 | R |
| Joe Saunders (7, 30) | 52 | L | |
| 95. | John Lannan (5, 26) | 51 | L |
| Ricky Nolasco (6, 28) | 51 | R | |
| 97. | Erik Bedard (8, 32) | 50 | L |
| Hector Carrasco (12, 41) | 50 | R | |
| R.A. Dickey (9, 36) | 50 | R | |
| 100. | Ubaldo Jimenez (6, 27) | 49 | R |
| Rank | Player (yrs, age) | Losses | Throws |
| Jorge De La Rosa (8, 30) | 49 | L |