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Single-Season Leaders & Records for Innings Pitched
+ - Indicates Hall of Famer. Bold indicates active player.
Only players who finished in the top 40 for the majors in a season will appear on this list. Leaders from the current season are only included for rate stats after July 1st.
| Rank | Player (age that year) | Innings Pitched | Year | Throws |
|---|---|---|---|---|
| 1. | Will White (24) | 680.00 | 1879 | R |
| 2. | Charley Radbourn+ (29) | 678.70 | 1884 | R |
| 3. | Guy Hecker (28) | 670.70 | 1884 | R |
| 4. | Jim McCormick (23) | 657.70 | 1880 | R |
| 5. | Pud Galvin+ (26) | 656.30 | 1883 | R |
| 6. | Pud Galvin+ (27) | 636.30 | 1884 | R |
| 7. | Charley Radbourn+ (28) | 632.30 | 1883 | R |
| 8. | John Clarkson+ (23) | 623.00 | 1885 | R |
| 9. | Jim Devlin (27) | 622.00 | 1876 | R |
| Bill Hutchison (32) | 622.00 | 1892 | R | |
| 11. | John Clarkson+ (27) | 620.00 | 1889 | R |
| 12. | Tim Keefe+ (26) | 619.00 | 1883 | R |
| 13. | Bill Hutchison (30) | 603.00 | 1890 | R |
| 14. | Jim McCormick (25) | 595.70 | 1882 | R |
| 15. | John Ward+ (20) | 595.00 | 1880 | R |
| 16. | Pud Galvin+ (22) | 593.00 | 1879 | R |
| 17. | Lee Richmond (23) | 590.70 | 1880 | L |
| 18. | Matt Kilroy (21) | 589.30 | 1887 | L |
| 19. | Toad Ramsey (21) | 588.70 | 1886 | L |
| 20. | Charlie Buffinton (23) | 587.00 | 1884 | R |
| John Ward+ (19) | 587.00 | 1879 | R | |
| 22. | Silver King (20) | 585.70 | 1888 | R |
| 23. | Matt Kilroy (20) | 583.00 | 1886 | L |
| 24. | Ed Morris (22) | 581.00 | 1885 | L |
| 25. | Will White (28) | 577.00 | 1883 | R |
| 26. | Mickey Welch+ (20) | 574.00 | 1880 | R |
| 27. | George Bradley (23) | 573.00 | 1876 | R |
| 28. | Jim McCormick (27) | 569.00 | 1884 | R |
| 29. | Tony Mullane (25) | 567.00 | 1884 | R |
| 30. | Bill Hutchison (31) | 561.00 | 1891 | R |
| Toad Ramsey (22) | 561.00 | 1887 | L | |
| 32. | Jim Devlin (28) | 559.00 | 1877 | R |
| 33. | Mickey Welch+ (24) | 557.30 | 1884 | R |
| 34. | Tommy Bond (23) | 555.30 | 1879 | R |
| Ed Morris (23) | 555.30 | 1886 | L | |
| 36. | Jim Whitney (23) | 552.30 | 1881 | R |
| 37. | Amos Rusie+ (19) | 548.70 | 1890 | R |
| 38. | Jim McCormick (22) | 546.30 | 1879 | R |
| 39. | Dupee Shaw (25) | 543.30 | 1884 | L |
| 40. | Hardie Henderson (22) | 539.30 | 1885 | R |
| 41. | John Coleman (20) | 538.30 | 1883 | R |
| 42. | Bill Sweeney () | 538.00 | 1884 | R |
| 43. | Larry Corcoran (20) | 536.30 | 1880 | R |
| 44. | Tim Keefe+ (29) | 535.00 | 1886 | R |
| 45. | Jersey Bakely (24) | 532.70 | 1888 | R |
| Tommy Bond (22) | 532.70 | 1878 | R | |
| 47. | Amos Rusie+ (21) | 532.00 | 1892 | R |
| 48. | Tony Mullane (27) | 529.70 | 1886 | R |
| 49. | Al Spalding+ (25) | 528.70 | 1876 | R |
| 50. | Jim McCormick (24) | 526.00 | 1881 | R |
| Rank | Player (age that year) | Innings Pitched | Year | Throws |
| 51. | John Clarkson+ (25) | 523.00 | 1887 | R |
| Billy Taylor (29) | 523.00 | 1884 | R | |
| 53. | Tommy Bond (21) | 521.00 | 1877 | R |
| 54. | Ed Seward (21) | 518.70 | 1888 | R |
| 55. | Will White (25) | 517.30 | 1880 | R |
| 56. | Larry Corcoran (24) | 516.70 | 1884 | R |
| 57. | Bobby Mathews (24) | 516.00 | 1876 | R |
| 58. | Jim Whitney (25) | 514.00 | 1883 | R |
| 59. | Mark Baldwin (25) | 513.70 | 1889 | R |
| 60. | Terry Larkin () | 513.30 | 1879 | R |
| 61. | Larry McKeon (18) | 512.00 | 1884 | |
| 62. | Charley Radbourn+ (31) | 509.30 | 1886 | R |
| 63. | Sadie McMahon (22) | 509.00 | 1890 | R |
| 64. | Kid Gleason (23) | 506.00 | 1890 | R |
| Terry Larkin () | 506.00 | 1878 | R | |
| 66. | Dave Foutz (29) | 504.00 | 1886 | R |
| 67. | Sadie McMahon (23) | 503.00 | 1891 | R |
| Frank Mountain (23) | 503.00 | 1883 | R | |
| 69. | Mark Baldwin (26) | 501.00 | 1890 | R |
| Terry Larkin () | 501.00 | 1877 | R | |
| 71. | Hugh Daily (36) | 500.70 | 1884 | R |
| 72. | Amos Rusie+ (20) | 500.30 | 1891 | R |
| 73. | Mickey Welch+ (26) | 500.00 | 1886 | R |
| 74. | Jack Lynch (27) | 496.00 | 1884 | R |
| 75. | George Derby (23) | 494.70 | 1881 | R |
| 76. | Bob Barr (33) | 493.30 | 1890 | R |
| 77. | Tommy Bond (24) | 493.00 | 1880 | R |
| 78. | Charlie Sweeney (21) | 492.00 | 1884 | R |
| Mickey Welch+ (25) | 492.00 | 1885 | R | |
| 80. | Phenomenal Smith (22) | 491.30 | 1887 | L |
| 81. | Lady Baldwin (27) | 487.00 | 1886 | L |
| George Bradley (26) | 487.00 | 1879 | R | |
| 83. | John Clarkson+ (26) | 483.30 | 1888 | R |
| 84. | Tim Keefe+ (27) | 483.00 | 1884 | R |
| 85. | Bob Caruthers (21) | 482.30 | 1885 | R |
| 86. | Amos Rusie+ (22) | 482.00 | 1893 | R |
| 87. | Henry Porter (27) | 481.70 | 1885 | R |
| 88. | Matt Kilroy (23) | 480.70 | 1889 | L |
| 89. | Guy Hecker (29) | 480.00 | 1885 | R |
| Ed Morris (25) | 480.00 | 1888 | L | |
| Will White (27) | 480.00 | 1882 | R | |
| 92. | Tim Keefe+ (30) | 476.70 | 1887 | R |
| 93. | Adonis Terry (19) | 476.00 | 1884 | R |
| 94. | Ed Beatin (23) | 474.30 | 1890 | L |
| 95. | Pud Galvin+ (24) | 474.00 | 1881 | R |
| Henry Porter (30) | 474.00 | 1888 | R | |
| Charley Radbourn+ (27) | 474.00 | 1882 | R | |
| 98. | Larry Corcoran (23) | 473.70 | 1883 | R |
| 99. | Ed Seward (20) | 470.70 | 1887 | R |
| 100. | Gus Weyhing (25) | 469.70 | 1892 | R |
| Rank | Player (age that year) | Innings Pitched | Year | Throws |
| 101. | Will White (23) | 468.00 | 1878 | R |
| 102. | John Clarkson+ (24) | 466.70 | 1886 | R |
| 103. | Gus Weyhing (20) | 466.30 | 1887 | R |
| 104. | Ed Walsh+ (27) | 464.00 | 1908 | R |
| 105. | Lee Richmond (24) | 462.30 | 1881 | L |
| 106. | Phil Knell (26) | 462.00 | 1891 | L |
| 107. | Silver King (22) | 461.00 | 1890 | R |
| 108. | John Clarkson+ (29) | 460.70 | 1891 | R |
| Tony Mullane (24) | 460.70 | 1883 | R | |
| 110. | Tony Mullane (23) | 460.30 | 1882 | R |
| 111. | Frank Killen (21) | 459.70 | 1892 | L |
| 112. | Pud Galvin+ (23) | 458.70 | 1880 | R |
| 113. | Silver King (21) | 458.00 | 1889 | R |
| 114. | Harry McCormick (23) | 457.30 | 1879 | R |
| 115. | Will White (29) | 456.00 | 1884 | R |
| 116. | Bob Emslie (25) | 455.30 | 1884 | R |
| 117. | Jack Chesbro+ (30) | 454.70 | 1904 | R |
| 118. | Bert Cunningham (22) | 453.30 | 1888 | R |
| 119. | Kid Nichols+ (22) | 453.00 | 1892 | R |
| Cy Young+ (25) | 453.00 | 1892 | R | |
| 121. | Guy Hecker (27) | 451.00 | 1883 | R |
| 122. | Gus Weyhing (24) | 450.00 | 1891 | R |
| 123. | Gus Weyhing (22) | 449.00 | 1889 | R |
| 124. | Ted Breitenstein (25) | 447.30 | 1894 | L |
| Elmer Smith (19) | 447.30 | 1887 | L | |
| 126. | Charley Radbourn+ (30) | 445.70 | 1885 | R |
| 127. | Pud Galvin+ (25) | 445.30 | 1882 | R |
| 128. | Bob Caruthers (25) | 445.00 | 1889 | R |
| 129. | Pink Hawley (22) | 444.30 | 1895 | R |
| 130. | Amos Rusie+ (23) | 444.00 | 1894 | R |
| 131. | Al Mays (22) | 441.30 | 1887 | |
| Jim Whitney (27) | 441.30 | 1885 | R | |
| 133. | Fleury Sullivan (22) | 441.00 | 1884 | |
| 134. | Pud Galvin+ (30) | 440.70 | 1887 | R |
| 135. | Mark Baldwin (28) | 440.30 | 1892 | R |
| 136. | Ed Daily (22) | 440.00 | 1885 | R |
| Jack Stivetts (23) | 440.00 | 1891 | R | |
| 138. | Hardie Henderson (21) | 439.30 | 1884 | R |
| 139. | Mark Baldwin (27) | 437.70 | 1891 | R |
| 140. | Pud Galvin+ (31) | 437.30 | 1888 | R |
| 141. | Pud Galvin+ (29) | 434.70 | 1886 | R |
| 142. | Charlie Buffinton (24) | 434.30 | 1885 | R |
| Tim Keefe+ (31) | 434.30 | 1888 | R | |
| 144. | Joe McGinnity+ (32) | 434.00 | 1903 | R |
| 145. | Jack Lynch (29) | 432.70 | 1886 | R |
| 146. | Frank Killen (25) | 432.30 | 1896 | L |
| 147. | Scott Stratton (20) | 431.00 | 1890 | R |
| 148. | Bobby Mathews (32) | 430.70 | 1884 | R |
| 149. | Ted Breitenstein (26) | 429.70 | 1895 | L |
| Ed Morris (21) | 429.70 | 1884 | L | |
| Rank | Player (age that year) | Innings Pitched | Year | Throws |
| 151. | Stump Wiedman (25) | 427.70 | 1886 | R |
| 152. | Tony Mullane (32) | 426.30 | 1891 | R |
| 153. | Mickey Welch+ (23) | 426.00 | 1883 | R |
| 154. | Kid Nichols+ (21) | 425.30 | 1891 | R |
| Mickey Welch+ (28) | 425.30 | 1888 | R | |
| 156. | Kid Nichols+ (23) | 425.00 | 1893 | R |
| Charley Radbourn+ (32) | 425.00 | 1887 | R | |
| 158. | Kid Nichols+ (20) | 424.00 | 1890 | R |
| Henry Porter (28) | 424.00 | 1886 | R | |
| 160. | Cy Young+ (24) | 423.70 | 1891 | R |
| 161. | Cy Young+ (26) | 422.70 | 1893 | R |
| 162. | Bobby Mathews (33) | 422.30 | 1885 | R |
| Ed Walsh+ (26) | 422.30 | 1907 | R | |
| 164. | Elton Chamberlain (21) | 421.70 | 1889 | R |
| 165. | Guy Hecker (30) | 420.70 | 1886 | R |
| 166. | Harry Staley (22) | 420.00 | 1889 | R |
| Jim Whitney (24) | 420.00 | 1882 | R | |
| 168. | Silver King (24) | 419.30 | 1892 | R |
| Jack Stivetts (22) | 419.30 | 1890 | R | |
| 170. | Sam Weaver (27) | 418.70 | 1883 | R |
| 171. | Kid Gleason (24) | 418.00 | 1891 | R |
| 172. | Charlie Ferguson (21) | 416.70 | 1884 | R |
| 173. | Tony Mullane (28) | 416.30 | 1887 | R |
| 174. | Jack Stivetts (24) | 415.70 | 1892 | R |
| 175. | Kid Carsey (20) | 415.00 | 1891 | R |
| Frank Killen (22) | 415.00 | 1893 | L | |
| 177. | Cy Young+ (29) | 414.30 | 1896 | R |
| 178. | Frank Foreman (26) | 414.00 | 1889 | L |
| 179. | Bob Barr (27) | 413.00 | 1884 | R |
| 180. | Lee Richmond (25) | 411.00 | 1882 | L |
| Stump Wiedman (21) | 411.00 | 1882 | R | |
| 182. | Park Swartzel (23) | 410.30 | 1889 | R |
| 183. | Vic Willis+ (26) | 410.00 | 1902 | R |
| 184. | Jouett Meekin (27) | 409.00 | 1894 | R |
| 185. | Cy Young+ (27) | 408.70 | 1894 | R |
| 186. | Tommy Bond (20) | 408.00 | 1876 | R |
| Joe McGinnity+ (33) | 408.00 | 1904 | R | |
| 188. | Dave Foutz (28) | 407.70 | 1885 | R |
| 189. | Kid Nichols+ (24) | 407.00 | 1894 | R |
| 190. | Elton Chamberlain (24) | 406.30 | 1892 | R |
| 191. | Elton Chamberlain (23) | 405.70 | 1891 | R |
| 192. | Charlie Ferguson (22) | 405.00 | 1885 | R |
| Fred Goldsmith (26) | 405.00 | 1882 | R | |
| 194. | Jim Whitney (29) | 404.70 | 1887 | R |
| 195. | Charlie Getzien (24) | 404.00 | 1888 | R |
| Gus Weyhing (21) | 404.00 | 1888 | R | |
| 197. | Hank O'Day (25) | 403.00 | 1888 | R |
| 198. | Stump Wiedman (22) | 402.30 | 1883 | R |
| 199. | Tim Keefe+ (24) | 402.00 | 1881 | R |
| 200. | Hank Gastright (25) | 401.30 | 1890 | R |
| Rank | Player (age that year) | Innings Pitched | Year | Throws |
| Billy Rhines (21) | 401.30 | 1890 | R | |
| 202. | Jesse Duryea (29) | 401.00 | 1889 | R |
| 203. | Charlie Buffinton (27) | 400.30 | 1888 | R |
| 204. | Kid Gleason (25) | 400.00 | 1892 | R |
| Tim Keefe+ (28) | 400.00 | 1885 | R | |
| 206. | Dupee Shaw (26) | 399.70 | 1885 | L |
| 207. | Jack Taylor (25) | 397.30 | 1898 | R |
| 208. | Sadie McMahon (24) | 397.00 | 1892 | R |
| 209. | Al Atkinson (25) | 396.70 | 1886 | R |
| Larry Corcoran (21) | 396.70 | 1881 | R | |
| 211. | Charlie Ferguson (23) | 395.70 | 1886 | R |
| 212. | Jersey Bakely (20) | 394.70 | 1884 | R |
| 213. | George Cobb (26) | 394.30 | 1892 | |
| 214. | George Bradley (24) | 394.00 | 1877 | R |
| 215. | Al Atkinson (23) | 393.70 | 1884 | R |
| 216. | Amos Rusie+ (24) | 393.30 | 1895 | R |
| 217. | Ed Walsh+ (31) | 393.00 | 1912 | R |
| Jim Whitney (28) | 393.00 | 1886 | R | |
| 219. | Dave Davenport (25) | 392.70 | 1915 | R |
| Pink Hawley (21) | 392.70 | 1894 | R | |
| 221. | Bob Caruthers (24) | 391.70 | 1888 | R |
| 222. | Pete Conway (21) | 391.00 | 1888 | R |
| John Harkins (25) | 391.00 | 1884 | R | |
| 224. | Christy Mathewson+ (27) | 390.70 | 1908 | R |
| 225. | Dan Casey (24) | 390.30 | 1887 | L |
| Jack Powell (29) | 390.30 | 1904 | R | |
| 227. | Silver King (19) | 390.00 | 1887 | R |
| Gus Weyhing (23) | 390.00 | 1890 | R | |
| 229. | Billy Crowell (21) | 389.30 | 1887 | R |
| Togie Pittinger (30) | 389.30 | 1902 | R | |
| 231. | Pete Alexander+ (29) | 389.00 | 1916 | R |
| John Clarkson+ (30) | 389.00 | 1892 | R | |
| John Healy (23) | 389.00 | 1890 | R | |
| 234. | Jumbo McGinnis (28) | 388.30 | 1882 | |
| 235. | Pete Alexander+ (30) | 388.00 | 1917 | R |
| Kid Nichols+ (28) | 388.00 | 1898 | R | |
| 237. | Harry Staley (23) | 387.70 | 1890 | R |
| Lee Viau (21) | 387.70 | 1888 | R | |
| 239. | Bob Caruthers (22) | 387.30 | 1886 | R |
| 240. | Charlie Getzien (22) | 386.70 | 1886 | R |
| 241. | Dupee Shaw (27) | 385.70 | 1886 | L |
| 242. | Cy Young+ (35) | 384.70 | 1902 | R |
| 243. | Silver King (23) | 384.30 | 1891 | R |
| 244. | Fred Goldsmith (27) | 383.30 | 1883 | R |
| Henry Gruber (26) | 383.30 | 1890 | R | |
| 246. | John Clarkson+ (28) | 383.00 | 1890 | R |
| Rube Waddell+ (27) | 383.00 | 1904 | L | |
| Sam Weaver (22) | 383.00 | 1878 | R | |
| 249. | Ted Breitenstein (24) | 382.70 | 1893 | L |
| Ad Gumbert (23) | 382.70 | 1892 | R | |
| Rank | Player (age that year) | Innings Pitched | Year | Throws |
| Brickyard Kennedy (25) | 382.70 | 1893 | R | |
| Jumbo McGinnis (29) | 382.70 | 1883 | ||
| 253. | George Mullin (23) | 382.30 | 1904 | R |
| 254. | Joe McGinnity+ (30) | 382.00 | 1901 | R |
| Tom Vickery (23) | 382.00 | 1890 | R | |
| 256. | George Haddock (25) | 381.30 | 1892 | R |
| 257. | Bobby Mathews (31) | 381.00 | 1883 | R |
| 258. | Kid Gleason (26) | 380.30 | 1893 | R |
| Tony Mullane (29) | 380.30 | 1888 | R | |
| 260. | Charlie Buffinton (28) | 380.00 | 1889 | R |
| Cy Young+ (37) | 380.00 | 1904 | R | |
| 262. | George Haddock (24) | 379.70 | 1891 | R |
| Kid Nichols+ (25) | 379.70 | 1895 | R | |
| 264. | Sam Leever (27) | 379.00 | 1899 | R |
| Jack Lynch (28) | 379.00 | 1885 | R | |
| 266. | Henry Boyle (28) | 378.70 | 1889 | R |
| Hugh Daily (35) | 378.70 | 1883 | R | |
| 268. | Pink Hawley (23) | 378.00 | 1896 | R |
| Irv Young (27) | 378.00 | 1905 | L | |
| 270. | Cy Young+ (31) | 377.70 | 1898 | R |
| 271. | Cy Falkenberg (33) | 377.30 | 1914 | R |
| Ed Stein (22) | 377.30 | 1892 | R | |
| 273. | Oscar Jones (24) | 377.00 | 1904 | R |
| 274. | Wilbur Wood (30) | 376.70 | 1972 | L |
| 275. | Pete Alexander+ (28) | 376.30 | 1915 | R |
| 276. | Nig Cuppy (22) | 376.00 | 1892 | R |
| Mickey Lolich (30) | 376.00 | 1971 | L | |
| 278. | Noodles Hahn (22) | 375.30 | 1901 | L |
| 279. | Frank Dwyer (23) | 375.00 | 1891 | R |
| Tim Keefe+ (25) | 375.00 | 1882 | R | |
| Mickey Welch+ (29) | 375.00 | 1889 | R | |
| 282. | Doc McJames (23) | 374.00 | 1898 | R |
| 283. | Jack Powell (24) | 373.00 | 1899 | R |
| Lee Viau (22) | 373.00 | 1889 | R | |
| 285. | Billy Rhines (22) | 372.70 | 1891 | R |
| 286. | Pud Galvin+ (28) | 372.30 | 1885 | R |
| Kid Nichols+ (26) | 372.30 | 1896 | R | |
| 288. | Tom Lovett (26) | 372.00 | 1890 | |
| 289. | Walter Johnson+ (26) | 371.70 | 1914 | R |
| 290. | Bill Dinneen (26) | 371.30 | 1902 | R |
| Bob Feller+ (27) | 371.30 | 1946 | R | |
| Cy Young+ (34) | 371.30 | 1901 | R | |
| 293. | Sam Weaver (26) | 371.00 | 1882 | R |
| 294. | Walter Johnson+ (22) | 370.00 | 1910 | R |
| Adonis Terry (25) | 370.00 | 1890 | R | |
| 296. | Walter Johnson+ (28) | 369.70 | 1916 | R |
| Ed Walsh+ (29) | 369.70 | 1910 | R | |
| Cy Young+ (28) | 369.70 | 1895 | R | |
| 299. | Cy Young+ (32) | 369.30 | 1899 | R |
| 300. | Dan Casey (23) | 369.00 | 1886 | L |
| Rank | Player (age that year) | Innings Pitched | Year | Throws |
| Walter Johnson+ (24) | 369.00 | 1912 | R | |
| 302. | Ed Walsh+ (30) | 368.70 | 1911 | R |
| 303. | Kid Nichols+ (27) | 368.00 | 1897 | R |
| Mickey Welch+ (21) | 368.00 | 1881 | R | |
| 305. | Christy Mathewson+ (23) | 367.70 | 1904 | R |
| 306. | Hardie Henderson (20) | 367.30 | 1883 | R |
| 307. | Pete Alexander+ (24) | 367.00 | 1911 | R |
| Tony Mullane (34) | 367.00 | 1893 | R | |
| 309. | Henry Boyle (24) | 366.70 | 1885 | R |
| Ed Crane (29) | 366.70 | 1891 | R | |
| Charlie Getzien (23) | 366.70 | 1887 | R | |
| 312. | Christy Mathewson+ (22) | 366.30 | 1903 | R |
| Joe McGinnity+ (28) | 366.30 | 1899 | R | |
| Win Mercer (22) | 366.30 | 1896 | R | |
| 315. | Tom Lovett (27) | 365.70 | 1891 | |
| 316. | Frank Smith (29) | 365.00 | 1909 | R |
| 317. | Ed Crane (30) | 364.30 | 1892 | R |
| Bill Wise (23) | 364.30 | 1884 | ||
| 319. | Red Ehret (20) | 364.00 | 1889 | R |
| Tim Keefe+ (32) | 364.00 | 1889 | R | |
| 321. | Charlie Buffinton (30) | 363.70 | 1891 | R |
| 322. | Pete Alexander+ (33) | 363.30 | 1920 | R |
| 323. | Mickey Hughes (21) | 363.00 | 1888 | R |
| 324. | Bert Cunningham (32) | 362.00 | 1898 | R |
| George Derby (24) | 362.00 | 1882 | R | |
| Claude Hendrix (25) | 362.00 | 1914 | R | |
| 327. | Bill Carrick (25) | 361.70 | 1899 | R |
| 328. | Sam Kimber (31) | 361.30 | 1884 | R |
| 329. | Gus Weyhing (31) | 361.00 | 1898 | R |
| 330. | Dan Casey (27) | 360.70 | 1890 | L |
| Brickyard Kennedy (26) | 360.70 | 1894 | R | |
| Frank Mountain (24) | 360.70 | 1884 | R | |
| 333. | George McQuillan (23) | 359.70 | 1908 | R |
| 334. | Wilbur Wood (31) | 359.30 | 1973 | L |
| 335. | Red Ehret (21) | 359.00 | 1890 | R |
| Jack Taylor (23) | 359.00 | 1896 | R | |
| 337. | Irv Young (28) | 358.30 | 1906 | L |
| 338. | Nig Cuppy (26) | 358.00 | 1896 | R |
| Doc Landis (27) | 358.00 | 1882 | ||
| 340. | Case Patten (30) | 357.70 | 1904 | L |
| George Uhle (24) | 357.70 | 1923 | R | |
| 342. | George Mullin (26) | 357.30 | 1907 | R |
| Eddie Plank+ (28) | 357.30 | 1904 | L | |
| 344. | Cy Seymour (25) | 356.70 | 1898 | L |
| 345. | Larry Corcoran (22) | 355.70 | 1882 | R |
| 346. | Pete Alexander+ (27) | 355.00 | 1914 | R |
| 347. | Jack Taylor (25) | 354.70 | 1899 | R |
| 348. | Jumbo McGinnis (30) | 354.30 | 1884 | |
| 349. | John Healy (19) | 353.70 | 1886 | R |
| 350. | Dummy Taylor (26) | 353.30 | 1901 | R |
| Rank | Player (age that year) | Innings Pitched | Year | Throws |
| 351. | Jack Coombs (27) | 353.00 | 1910 | R |
| Nig Cuppy (25) | 353.00 | 1895 | R | |
| Clark Griffith+ (25) | 353.00 | 1895 | R | |
| 354. | John Keefe (23) | 352.30 | 1890 | L |
| Stoney McGlynn (35) | 352.30 | 1907 | R | |
| Dizzy Trout (29) | 352.30 | 1944 | R | |
| 357. | Red Faber+ (33) | 352.00 | 1922 | R |
| Jack Taylor (30) | 352.00 | 1904 | R | |
| 359. | Joe McGinnity+ (31) | 351.70 | 1902 | R |
| Togie Pittinger (31) | 351.70 | 1903 | R | |
| Scott Stratton (22) | 351.70 | 1892 | R | |
| 362. | Dad Clarke (31) | 351.00 | 1896 | R |
| Bill Donovan (24) | 351.00 | 1901 | R | |
| 364. | Charlie Getzien (26) | 350.00 | 1890 | R |
| Al Mays (21) | 350.00 | 1886 | ||
| Tricky Nichols (26) | 350.00 | 1877 | R | |
| Ed Stein (24) | 350.00 | 1894 | R | |
| Vic Willis+ (28) | 350.00 | 1904 | R | |
| 369. | Ben Sanders (24) | 349.70 | 1889 | R |
| 370. | Chick Fraser (22) | 349.30 | 1896 | R |
| 371. | Charlie Getzien (25) | 349.00 | 1889 | R |
| 372. | Henry Gruber (27) | 348.70 | 1891 | R |
| Toad Ramsey (25) | 348.70 | 1890 | L | |
| Bill Stemmeyer (21) | 348.70 | 1886 | R | |
| 375. | Bill Hutchison (33) | 348.30 | 1893 | R |
| Elmer Smith (20) | 348.30 | 1888 | L | |
| 377. | Red Donahue (24) | 348.00 | 1897 | R |
| Frank Dwyer (26) | 348.00 | 1894 | R | |
| Bob Harmon (23) | 348.00 | 1911 | R | |
| Urban Shocker (31) | 348.00 | 1922 | R | |
| 381. | Jim McCormick (29) | 347.70 | 1886 | R |
| George Mullin (24) | 347.70 | 1905 | R | |
| 383. | The Only Nolan (20) | 347.00 | 1878 | R |
| 384. | Eddie Cicotte (33) | 346.70 | 1917 | R |
| Red Ehret (25) | 346.70 | 1894 | R | |
| Darby O'Brien (22) | 346.70 | 1889 | R | |
| Eddie Plank+ (29) | 346.70 | 1905 | L | |
| Robin Roberts+ (26) | 346.70 | 1953 | R | |
| Ben Sanders (25) | 346.70 | 1890 | R | |
| 390. | Steve Carlton+ (27) | 346.30 | 1972 | L |
| Sadie McMahon (25) | 346.30 | 1893 | R | |
| 392. | Walter Johnson+ (25) | 346.00 | 1913 | R |
| Mickey Welch+ (27) | 346.00 | 1887 | R | |
| 394. | Frank Foreman (28) | 345.30 | 1891 | L |
| Gus Weyhing (26) | 345.30 | 1893 | R | |
| 396. | Ed Daily (27) | 344.70 | 1890 | R |
| 397. | Gaylord Perry+ (34) | 344.00 | 1973 | R |
| Joe Wood (22) | 344.00 | 1912 | R | |
| 399. | Clark Griffith+ (27) | 343.70 | 1897 | R |
| Eddie Plank+ (31) | 343.70 | 1907 | L | |
| Rank | Player (age that year) | Innings Pitched | Year | Throws |
| Lee Viau (24) | 343.70 | 1891 | R | |
| 402. | Brickyard Kennedy (29) | 343.30 | 1897 | R |
| Kid Nichols+ (29) | 343.30 | 1899 | R | |
| Cy Young+ (40) | 343.30 | 1907 | R | |
| 405. | Bob Feller+ (22) | 343.00 | 1941 | R |
| Joe McGinnity+ (29) | 343.00 | 1900 | R | |
| Charley Radbourn+ (35) | 343.00 | 1890 | R | |
| 408. | Mordecai Brown+ (32) | 342.70 | 1909 | R |
| Gaylord Perry+ (33) | 342.70 | 1972 | R | |
| Jack Quinn (30) | 342.70 | 1914 | R | |
| Vic Willis+ (23) | 342.70 | 1899 | R | |
| 412. | Kid Carsey (24) | 342.30 | 1895 | R |
| Toad Ramsey (23) | 342.30 | 1888 | L | |
| 414. | George Bradley (31) | 342.00 | 1884 | R |
| Jim McCormick (26) | 342.00 | 1883 | R | |
| Phil Niekro+ (40) | 342.00 | 1979 | R | |
| Jack Powell (23) | 342.00 | 1898 | R | |
| Vic Willis+ (29) | 342.00 | 1905 | R | |
| 419. | Bill Carrick (26) | 341.70 | 1900 | R |
| Cy Young+ (36) | 341.70 | 1903 | R | |
| 421. | Dick Rudolph (27) | 341.30 | 1915 | R |
| 422. | Bob Caruthers (23) | 341.00 | 1887 | R |
| Pud Galvin+ (32) | 341.00 | 1889 | R | |
| John Healy (20) | 341.00 | 1887 | R | |
| 425. | Jim Bagby (30) | 339.70 | 1920 | R |
| Ted Breitenstein (27) | 339.70 | 1896 | L | |
| George Hemming (25) | 339.70 | 1894 | R | |
| Gus Krock (22) | 339.70 | 1888 | L | |
| Joe McGinnity+ (35) | 339.70 | 1906 | R | |
| Henry Porter (29) | 339.70 | 1887 | R | |
| Fred Toney (28) | 339.70 | 1917 | R | |
| 432. | Dave Foutz (30) | 339.30 | 1887 | R |
| Brickyard Kennedy (30) | 339.30 | 1898 | R | |
| 434. | Addie Joss+ (27) | 338.70 | 1907 | R |
| Christy Mathewson+ (24) | 338.70 | 1905 | R | |
| Al Orth (33) | 338.70 | 1906 | R | |
| 437. | Jack Powell (26) | 338.30 | 1901 | R |
| 438. | Jack Stivetts (26) | 338.00 | 1894 | R |
| 439. | Frank Killen (26) | 337.30 | 1897 | L |
| Togie Pittinger (33) | 337.30 | 1905 | R | |
| 441. | Jack Coombs (28) | 336.70 | 1911 | R |
| Walter Johnson+ (27) | 336.70 | 1915 | R | |
| Carl Mays (29) | 336.70 | 1921 | R | |
| Robin Roberts+ (27) | 336.70 | 1954 | R | |
| 445. | Denny Driscoll (27) | 336.30 | 1883 | L |
| Win Mercer (20) | 336.30 | 1894 | R | |
| Dick Rudolph (26) | 336.30 | 1914 | R | |
| 448. | Bill Hart (30) | 336.00 | 1896 | R |
| Christy Mathewson+ (20) | 336.00 | 1901 | R | |
| Denny McLain (24) | 336.00 | 1968 | R | |
| Rank | Player (age that year) | Innings Pitched | Year | Throws |
| Eddie Plank+ (27) | 336.00 | 1903 | L | |
| Jim Whitney (26) | 336.00 | 1884 | R | |
| 453. | Bill Dinneen (28) | 335.70 | 1904 | R |
| Sandy Koufax+ (29) | 335.70 | 1965 | L | |
| 455. | Togie Pittinger (32) | 335.30 | 1904 | R |
| 456. | Jim Conway (30) | 335.00 | 1889 | R |
| Harry Salisbury (27) | 335.00 | 1882 | ||
| Jack Taylor (22) | 335.00 | 1895 | R | |
| 459. | Gus Weyhing (32) | 334.70 | 1899 | R |
| 460. | Duke Esper (24) | 334.30 | 1893 | L |
| Chick Fraser (31) | 334.30 | 1905 | R | |
| Jouett Meekin (29) | 334.30 | 1896 | R | |
| Phil Niekro+ (39) | 334.30 | 1978 | R | |
| 464. | Mark Baldwin (23) | 334.00 | 1887 | R |
| Frank Owen (25) | 334.00 | 1905 | R | |
| John Ward+ (18) | 334.00 | 1878 | R | |
| Wilbur Wood (29) | 334.00 | 1971 | L | |
| 468. | Mark Baldwin (29) | 333.70 | 1893 | R |
| Otto Hess (27) | 333.70 | 1906 | L | |
| Pete Schneider (21) | 333.70 | 1917 | R | |
| Cy Young+ (30) | 333.70 | 1897 | R | |
| 472. | Nap Rucker (23) | 333.30 | 1908 | L |
| 473. | Charlie Buffinton (22) | 333.00 | 1883 | R |
| Nat Hudson (29) | 333.00 | 1888 | R | |
| Win Mercer (23) | 333.00 | 1897 | R | |
| 476. | Bob Ewing (34) | 332.70 | 1907 | R |
| Nolan Ryan+ (27) | 332.70 | 1974 | R | |
| 478. | Charlie Buffinton (26) | 332.30 | 1887 | R |
| Bill James (22) | 332.30 | 1914 | R | |
| Scott Perry (27) | 332.30 | 1918 | R | |
| 481. | George Hemming (24) | 332.00 | 1893 | R |
| Roscoe Miller (24) | 332.00 | 1901 | R | |
| Kaiser Wilhelm (34) | 332.00 | 1908 | R | |
| 484. | Ed Killian (27) | 331.70 | 1904 | L |
| 485. | John Ewing (26) | 331.00 | 1889 | R |
| Chick Fraser (27) | 331.00 | 1901 | R | |
| Pink Hawley (25) | 331.00 | 1898 | R | |
| 488. | Red Faber+ (32) | 330.70 | 1921 | R |
| Burleigh Grimes+ (34) | 330.70 | 1928 | R | |
| 490. | Ed Crane (28) | 330.30 | 1890 | R |
| Phil Niekro+ (38) | 330.30 | 1977 | R | |
| George Pechiney (24) | 330.30 | 1886 | R | |
| 493. | Charlie Getzien (21) | 330.00 | 1885 | R |
| Fred Goldsmith (25) | 330.00 | 1881 | R | |
| George Mullin (25) | 330.00 | 1906 | R | |
| Robin Roberts+ (25) | 330.00 | 1952 | R | |
| John Ward+ (21) | 330.00 | 1881 | R | |
| Stump Wiedman (24) | 330.00 | 1885 | R | |
| Hooks Wiltse (28) | 330.00 | 1908 | L | |
| 500. | Dick Burns (20) | 329.70 | 1884 | L |
| Rank | Player (age that year) | Innings Pitched | Year | Throws |
| Bobo Newsom (30) | 329.70 | 1938 | R |
Note that seasons prior to 1876 are not included in single-season marks, but are included in career marks.
