+ - Indicates Hall of Famer. Bold indicates active player.
Statistic Description: Games Played or Pitched
| Rank | Player (yrs, age) | Games Played | Throws |
|---|---|---|---|
| 1. | Mariano Rivera (18, 42) | 1051 | R |
| 2. | LaTroy Hawkins (18, 39) | 871 | R |
| 3. | Kyle Farnsworth (14, 36) | 810 | R |
| 4. | Francisco Cordero (14, 37) | 800 | R |
| 5. | Octavio Dotel (14, 38) | 752 | R |
| 6. | Guillermo Mota (14, 38) | 743 | R |
| 7. | Jason Isringhausen (16, 39) | 724 | R |
| 8. | Darren Oliver (19, 41) | 716 | L |
| 9. | Jamie Moyer (25, 49) | 696 | L |
| 10. | Francisco Rodriguez (11, 30) | 682 | R |
| 11. | J.C. Romero (14, 36) | 680 | L |
| 12. | Derek Lowe (16, 39) | 672 | R |
| 13. | Miguel Batista (18, 41) | 658 | R |
| 14. | Brian Fuentes (12, 36) | 650 | L |
| 15. | Hector Carrasco (12, 42) | 647 | R |
| Joe Nathan (12, 37) | 647 | R | |
| 17. | Jeremy Affeldt (11, 33) | 621 | L |
| 18. | Rafael Betancourt (10, 37) | 603 | R |
| Brad Lidge (11, 35) | 603 | R | |
| 20. | Chad Qualls (9, 33) | 597 | R |
| 21. | Jamey Wright (17, 37) | 592 | R |
| 22. | Dan Wheeler (13, 34) | 589 | R |
| 23. | Jose Valverde (10, 34) | 585 | R |
| 24. | Ricardo Rincon (11, 42) | 565 | L |
| 25. | Javier Lopez (10, 34) | 560 | L |
| 26. | Ryan Dempster (15, 35) | 547 | R |
| 27. | Matt Thornton (9, 35) | 546 | L |
| 28. | Jon Rauch (10, 33) | 541 | R |
| 29. | Brandon Lyon (11, 32) | 535 | R |
| 30. | Jason Frasor (9, 34) | 525 | R |
| 31. | Livan Hernandez (17, 37) | 519 | R |
| 32. | Ron Mahay (15, 41) | 514 | L |
| J.J. Putz (10, 35) | 514 | R | |
| 34. | Shawn Camp (9, 36) | 512 | R |
| 35. | Kevin Gregg (10, 34) | 509 | R |
| 36. | Heath Bell (9, 34) | 508 | R |
| 37. | Andy Pettitte (17, 40) | 501 | L |
| 38. | Scott Downs (11, 36) | 496 | L |
| 39. | Luis Ayala (8, 34) | 495 | R |
| Fernando Rodney (10, 35) | 495 | R | |
| 41. | Jesse Crain (9, 30) | 494 | R |
| 42. | Ryan Madson (9, 31) | 491 | R |
| 43. | Will Ohman (10, 34) | 483 | L |
| 44. | Matt Guerrier (9, 33) | 479 | R |
| 45. | Aaron Heilman (9, 33) | 477 | R |
| 46. | Randy Choate (12, 36) | 476 | L |
| 47. | Joaquin Benoit (11, 34) | 475 | R |
| 48. | Esteban Yan (11, 37) | 472 | R |
| 49. | Tim Byrdak (11, 38) | 471 | L |
| 50. | Jonathan Papelbon (8, 31) | 466 | R |
| Rank | Player (yrs, age) | Games Played | Throws |
| 51. | Todd Coffey (8, 31) | 461 | R |
| 52. | Pedro Feliciano (8, 35) | 459 | L |
| 53. | Huston Street (8, 28) | 457 | R |
| 54. | Rafael Soriano (11, 32) | 453 | R |
| 55. | Carlos Marmol (7, 29) | 452 | R |
| 56. | Kevin Millwood (16, 37) | 451 | R |
| 57. | Jeff Suppan (17, 37) | 448 | R |
| 58. | Juan Cruz (12, 33) | 447 | R |
| 59. | Jonathan Broxton (8, 28) | 446 | R |
| Kerry Wood (14, 35) | 446 | R | |
| 61. | Matt Capps (8, 28) | 444 | R |
| Juan Rincon (10, 33) | 444 | R | |
| 63. | George Sherrill (9, 35) | 442 | L |
| 64. | Chad Durbin (13, 34) | 440 | R |
| 65. | Mike Gonzalez (10, 34) | 434 | L |
| 66. | Mark Buehrle (13, 33) | 421 | L |
| 67. | Ramon Ramirez (7, 30) | 417 | R |
| 68. | Mike MacDougal (12, 35) | 407 | R |
| Joel Peralta (8, 36) | 407 | R | |
| 70. | Tim Hudson (14, 36) | 406 | R |
| 71. | Roy Halladay (15, 35) | 403 | R |
| 72. | Barry Zito (13, 34) | 400 | L |
| 73. | Grant Balfour (9, 34) | 398 | R |
| 74. | Brett Tomko (14, 39) | 397 | R |
| 75. | Matt Belisle (9, 32) | 386 | R |
| Vicente Padilla (14, 34) | 386 | R | |
| 77. | CC Sabathia (12, 31) | 383 | L |
| 78. | Bartolo Colon (15, 39) | 381 | R |
| 79. | Frank Francisco (8, 32) | 379 | R |
| 80. | Brandon League (9, 29) | 377 | R |
| Brett Myers (11, 31) | 377 | R | |
| 82. | Randy Wolf (14, 35) | 376 | L |
| 83. | Joe Smith (6, 28) | 369 | R |
| 84. | Juan Acevedo (8, 42) | 367 | R |
| 85. | Sean Marshall (7, 29) | 365 | L |
| 86. | Johan Santana (12, 33) | 360 | L |
| 87. | Bronson Arroyo (13, 35) | 359 | R |
| Freddy Garcia (14, 35) | 359 | R | |
| Boone Logan (7, 27) | 359 | L | |
| C.J. Wilson (8, 31) | 359 | L | |
| 91. | Mike Adams (8, 33) | 358 | R |
| Craig Breslow (7, 31) | 358 | L | |
| Matt Lindstrom (6, 32) | 358 | R | |
| 94. | Roy Oswalt (12, 34) | 356 | R |
| 95. | Kyle Lohse (12, 33) | 355 | R |
| 96. | Sean Burnett (6, 29) | 354 | L |
| Eric O'Flaherty (7, 27) | 354 | L | |
| Carlos Zambrano (12, 31) | 354 | R | |
| 99. | Joel Hanrahan (6, 30) | 353 | R |
| 100. | Bruce Chen (14, 35) | 351 | L |
| Rank | Player (yrs, age) | Games Played | Throws |
| Ted Lilly (14, 36) | 351 | L |