+ - Indicates Hall of Famer. Bold indicates active player.
Statistic Description: Games Played or Pitched
| Rank | Player (yrs, age) | Games Played | Throws |
|---|---|---|---|
| 1. | Mariano Rivera (19, 43) | 1069 | R |
| 2. | LaTroy Hawkins (19, 40) | 888 | R |
| 3. | Kyle Farnsworth (15, 37) | 822 | R |
| 4. | Octavio Dotel (15, 39) | 758 | R |
| 5. | Darren Oliver (20, 42) | 732 | L |
| 6. | Francisco Rodriguez (11, 31) | 682 | R |
| 7. | Derek Lowe (17, 40) | 680 | R |
| J.C. Romero (14, 37) | 680 | L | |
| 9. | Dennys Reyes (15, 36) | 673 | L |
| 10. | Joe Nathan (13, 38) | 663 | R |
| 11. | Miguel Batista (18, 42) | 658 | R |
| 12. | Jeremy Affeldt (12, 34) | 633 | L |
| 13. | Rafael Betancourt (11, 38) | 619 | R |
| 14. | Chad Qualls (10, 34) | 611 | R |
| 15. | Jamey Wright (18, 38) | 609 | R |
| 16. | Jose Valverde (11, 35) | 592 | R |
| 17. | Dan Wheeler (13, 35) | 589 | R |
| 18. | Javier Lopez (11, 35) | 577 | L |
| 19. | Matt Thornton (10, 36) | 564 | L |
| 20. | Ryan Dempster (16, 36) | 555 | R |
| Jon Rauch (11, 34) | 555 | R | |
| 22. | Brandon Lyon (12, 33) | 553 | R |
| 23. | Luis Vizcaino (11, 38) | 543 | R |
| 24. | Jason Frasor (10, 35) | 540 | R |
| 25. | Shawn Camp (10, 37) | 531 | R |
| 26. | J.J. Putz (11, 36) | 528 | R |
| 27. | Heath Bell (10, 35) | 526 | R |
| 28. | Kevin Gregg (11, 35) | 519 | R |
| 29. | Jesse Crain (10, 31) | 514 | R |
| 30. | Scott Downs (12, 37) | 513 | L |
| 31. | Fernando Rodney (11, 36) | 510 | R |
| 32. | Andy Pettitte (18, 41) | 508 | L |
| 33. | Luis Ayala (9, 35) | 502 | R |
| 34. | Matt Guerrier (10, 34) | 495 | R |
| 35. | Joaquin Benoit (12, 35) | 492 | R |
| 36. | Ryan Madson (9, 32) | 491 | R |
| 37. | Randy Choate (13, 37) | 488 | L |
| 38. | Jonathan Papelbon (9, 32) | 482 | R |
| 39. | Huston Street (9, 29) | 473 | R |
| 40. | Rafael Soriano (12, 33) | 470 | R |
| 41. | Carlos Marmol (8, 30) | 469 | R |
| 42. | Jonathan Broxton (9, 29) | 463 | R |
| 43. | Pedro Feliciano (8, 36) | 459 | L |
| 44. | Mike Gonzalez (11, 35) | 454 | L |
| 45. | Chad Durbin (14, 35) | 451 | R |
| 46. | Matt Capps (8, 29) | 444 | R |
| 47. | George Sherrill (9, 36) | 442 | L |
| 48. | Mark Buehrle (14, 34) | 429 | L |
| 49. | Joel Peralta (9, 37) | 426 | R |
| 50. | Ramon Ramirez (7, 31) | 417 | R |
| Rank | Player (yrs, age) | Games Played | Throws |
| 51. | Tim Hudson (15, 37) | 414 | R |
| 52. | Grant Balfour (10, 35) | 413 | R |
| 53. | Kelvim Escobar (12, 37) | 411 | R |
| 54. | Roy Halladay (16, 36) | 410 | R |
| 55. | Barry Zito (14, 35) | 408 | L |
| 56. | Mike MacDougal (12, 36) | 407 | R |
| 57. | Matt Belisle (10, 33) | 403 | R |
| 58. | CC Sabathia (13, 32) | 392 | L |
| 59. | Brandon League (10, 30) | 391 | R |
| 60. | Bartolo Colon (16, 40) | 389 | R |
| 61. | Joe Smith (7, 29) | 384 | R |
| 62. | Brett Myers (12, 32) | 381 | R |
| 63. | Frank Francisco (8, 33) | 379 | R |
| 64. | Esteban Loaiza (14, 41) | 377 | R |
| 65. | Matt Lindstrom (7, 33) | 376 | R |
| 66. | Mike Adams (9, 34) | 375 | R |
| 67. | Boone Logan (8, 28) | 373 | L |
| 68. | Sean Marshall (8, 30) | 372 | L |
| Eric O'Flaherty (8, 28) | 372 | L | |
| 70. | Juan Acevedo (8, 43) | 367 | R |
| Bronson Arroyo (14, 36) | 367 | R | |
| C.J. Wilson (9, 32) | 367 | L | |
| 73. | Sean Burnett (7, 30) | 365 | L |
| 74. | Craig Breslow (8, 32) | 363 | L |
| Kyle Lohse (13, 34) | 363 | R | |
| 76. | Joel Hanrahan (7, 31) | 362 | R |
| 77. | Freddy Garcia (15, 36) | 361 | R |
| 78. | Jon Garland (13, 33) | 360 | R |
| Johan Santana (12, 34) | 360 | L | |
| 80. | Bruce Chen (15, 36) | 358 | L |
| 81. | Jason Marquis (14, 34) | 355 | R |
| 82. | A.J. Burnett (15, 36) | 354 | R |
| 83. | Ted Lilly (15, 37) | 353 | L |
| 84. | Chris Carpenter (15, 38) | 350 | R |
| 85. | Jason Grilli (11, 36) | 349 | R |
| 86. | Santiago Casilla (10, 32) | 345 | R |
| Brad Ziegler (6, 33) | 345 | R | |
| 88. | Jose Veras (8, 32) | 342 | R |
| 89. | Rafael Perez (7, 31) | 338 | L |
| 90. | Edward Mujica (8, 29) | 331 | R |
| 91. | Manny Corpas (6, 30) | 328 | R |
| Mark Hendrickson (10, 39) | 328 | L | |
| 93. | Chad Gaudin (11, 30) | 326 | R |
| 94. | Juan Carlos Oviedo (7, 31) | 317 | R |
| 95. | Josh Beckett (13, 33) | 315 | R |
| 96. | Chad Cordero (7, 31) | 314 | R |
| 97. | Kameron Loe (9, 31) | 313 | R |
| 98. | Matt Albers (8, 30) | 311 | R |
| 99. | Luke Gregerson (5, 29) | 309 | R |
| Carlos Villanueva (8, 29) | 309 | R |