+ - Indicates Hall of Famer. Bold indicates active player.
Statistic Description: Games Played or Pitched
| Rank | Player (yrs, age) | Games Played | Throws |
|---|---|---|---|
| 1. | Mariano Rivera (19, 43) | 1070 | R |
| 2. | LaTroy Hawkins (19, 40) | 891 | R |
| 3. | Kyle Farnsworth (15, 37) | 826 | R |
| 4. | Octavio Dotel (15, 39) | 758 | R |
| 5. | Darren Oliver (20, 42) | 733 | L |
| 6. | Francisco Rodriguez (12, 31) | 685 | R |
| 7. | Derek Lowe (17, 40) | 681 | R |
| 8. | J.C. Romero (14, 37) | 680 | L |
| 9. | Dennys Reyes (15, 36) | 673 | L |
| 10. | Joe Nathan (13, 38) | 666 | R |
| 11. | Miguel Batista (18, 42) | 658 | R |
| 12. | Jeremy Affeldt (12, 34) | 637 | L |
| 13. | Rafael Betancourt (11, 38) | 622 | R |
| 14. | Chad Qualls (10, 34) | 614 | R |
| 15. | Jamey Wright (18, 38) | 611 | R |
| 16. | Jose Valverde (11, 35) | 595 | R |
| 17. | Dan Wheeler (13, 35) | 589 | R |
| 18. | Javier Lopez (11, 35) | 581 | L |
| 19. | Matt Thornton (10, 36) | 567 | L |
| 20. | Ryan Dempster (16, 36) | 556 | R |
| Brandon Lyon (12, 33) | 556 | R | |
| Jon Rauch (11, 34) | 556 | R | |
| 23. | Luis Vizcaino (11, 38) | 543 | R |
| 24. | Jason Frasor (10, 35) | 542 | R |
| 25. | Shawn Camp (10, 37) | 532 | R |
| 26. | J.J. Putz (11, 36) | 528 | R |
| 27. | Heath Bell (10, 35) | 527 | R |
| 28. | Kevin Gregg (11, 35) | 521 | R |
| 29. | Jesse Crain (10, 31) | 518 | R |
| 30. | Scott Downs (12, 37) | 515 | L |
| 31. | Fernando Rodney (11, 36) | 514 | R |
| 32. | Andy Pettitte (18, 41) | 509 | L |
| 33. | Luis Ayala (9, 35) | 502 | R |
| 34. | Matt Guerrier (10, 34) | 498 | R |
| 35. | Joaquin Benoit (12, 35) | 494 | R |
| 36. | Ryan Madson (9, 32) | 491 | R |
| 37. | Randy Choate (13, 37) | 490 | L |
| 38. | Jonathan Papelbon (9, 32) | 483 | R |
| 39. | Huston Street (9, 29) | 477 | R |
| 40. | Rafael Soriano (12, 33) | 474 | R |
| 41. | Carlos Marmol (8, 30) | 471 | R |
| 42. | Jonathan Broxton (9, 29) | 466 | R |
| 43. | Pedro Feliciano (8, 36) | 459 | L |
| Mike Gonzalez (11, 35) | 459 | L | |
| 45. | Chad Durbin (14, 35) | 453 | R |
| 46. | Matt Capps (8, 29) | 444 | R |
| 47. | George Sherrill (9, 36) | 442 | L |
| 48. | Mark Buehrle (14, 34) | 431 | L |
| Joel Peralta (9, 37) | 431 | R | |
| 50. | Ramon Ramirez (7, 31) | 417 | R |
| Rank | Player (yrs, age) | Games Played | Throws |
| 51. | Grant Balfour (10, 35) | 416 | R |
| Tim Hudson (15, 37) | 416 | R | |
| 53. | Kelvim Escobar (12, 37) | 411 | R |
| 54. | Roy Halladay (16, 36) | 410 | R |
| 55. | Barry Zito (14, 35) | 409 | L |
| 56. | Matt Belisle (10, 33) | 408 | R |
| 57. | Mike MacDougal (12, 36) | 407 | R |
| 58. | Brandon League (10, 30) | 394 | R |
| 59. | CC Sabathia (13, 32) | 393 | L |
| 60. | Bartolo Colon (16, 40) | 390 | R |
| 61. | Joe Smith (7, 29) | 386 | R |
| 62. | Brett Myers (12, 32) | 381 | R |
| 63. | Matt Lindstrom (7, 33) | 380 | R |
| 64. | Frank Francisco (8, 33) | 379 | R |
| 65. | Esteban Loaiza (14, 41) | 377 | R |
| Boone Logan (8, 28) | 377 | L | |
| 67. | Sean Marshall (8, 30) | 376 | L |
| 68. | Mike Adams (9, 34) | 375 | R |
| 69. | Eric O'Flaherty (8, 28) | 373 | L |
| 70. | C.J. Wilson (9, 32) | 369 | L |
| 71. | Bronson Arroyo (14, 36) | 368 | R |
| 72. | Juan Acevedo (8, 43) | 367 | R |
| 73. | Craig Breslow (8, 32) | 366 | L |
| 74. | Sean Burnett (7, 30) | 365 | L |
| 75. | Kyle Lohse (13, 34) | 364 | R |
| 76. | Freddy Garcia (15, 36) | 363 | R |
| 77. | Jon Garland (13, 33) | 362 | R |
| Joel Hanrahan (7, 31) | 362 | R | |
| 79. | Bruce Chen (15, 36) | 360 | L |
| Johan Santana (12, 34) | 360 | L | |
| 81. | Jason Marquis (14, 34) | 357 | R |
| 82. | A.J. Burnett (15, 36) | 355 | R |
| 83. | Jason Grilli (11, 36) | 353 | R |
| Ted Lilly (15, 37) | 353 | L | |
| 85. | Chris Carpenter (15, 38) | 350 | R |
| 86. | Brad Ziegler (6, 33) | 348 | R |
| 87. | Santiago Casilla (10, 32) | 347 | R |
| 88. | Jose Veras (8, 32) | 346 | R |
| 89. | Rafael Perez (7, 31) | 338 | L |
| 90. | Edward Mujica (8, 29) | 336 | R |
| 91. | Chad Gaudin (11, 30) | 329 | R |
| 92. | Manny Corpas (6, 30) | 328 | R |
| Mark Hendrickson (10, 39) | 328 | L | |
| 94. | Ismael Valdez (12, 39) | 325 | R |
| 95. | Juan Carlos Oviedo (7, 31) | 317 | R |
| 96. | Josh Beckett (13, 33) | 315 | R |
| 97. | Matt Albers (8, 30) | 314 | R |
| Chad Cordero (7, 31) | 314 | R | |
| 99. | Kameron Loe (9, 31) | 313 | R |
| 100. | Luke Gregerson (5, 29) | 311 | R |