+ - Indicates Hall of Famer. Bold indicates active player.
Statistic Description: Games Played or Pitched
| Rank | Player (yrs, age) | Games Played | Bats |
|---|---|---|---|
| 1. | Omar Vizquel (24, 45) | 2968 | B |
| 2. | Derek Jeter (18, 38) | 2585 | R |
| 3. | Jim Thome (22, 41) | 2543 | L |
| 4. | Alex Rodriguez (19, 36) | 2524 | R |
| 5. | Chipper Jones (19, 40) | 2499 | B |
| 6. | Johnny Damon (18, 38) | 2490 | L |
| 7. | Bobby Abreu (17, 38) | 2347 | L |
| 8. | Manny Ramirez (19, 40) | 2302 | R |
| 9. | Andruw Jones (17, 35) | 2196 | R |
| 10. | Jason Giambi (18, 41) | 2163 | L |
| 11. | Vladimir Guerrero (16, 37) | 2147 | R |
| 12. | Paul Konerko (16, 36) | 2142 | R |
| 13. | Todd Helton (16, 38) | 2123 | L |
| 14. | Miguel Tejada (15, 38) | 2118 | R |
| 15. | Adrian Beltre (15, 33) | 2115 | R |
| 16. | Carlos Lee (14, 36) | 2099 | R |
| 17. | Jason Kendall (15, 38) | 2085 | R |
| 18. | Scott Rolen (17, 37) | 2038 | R |
| 19. | Torii Hunter (16, 36) | 1947 | R |
| Raul Ibanez (17, 40) | 1947 | L | |
| 21. | Carlos Beltran (15, 35) | 1919 | B |
| 22. | Ichiro Suzuki (12, 38) | 1911 | L |
| 23. | Juan Pierre (13, 34) | 1881 | L |
| 24. | Albert Pujols (12, 32) | 1859 | R |
| 25. | David Ortiz (16, 36) | 1832 | L |
| Aramis Ramirez (15, 34) | 1832 | R | |
| 27. | Michael Young (13, 35) | 1823 | R |
| 28. | Mark Kotsay (16, 36) | 1810 | L |
| 29. | Placido Polanco (15, 36) | 1809 | R |
| 30. | Lance Berkman (14, 36) | 1806 | B |
| 31. | Jimmy Rollins (13, 33) | 1792 | B |
| 32. | Alfonso Soriano (14, 36) | 1757 | R |
| 33. | Adam Dunn (12, 32) | 1721 | L |
| 34. | Adam Kennedy (14, 36) | 1691 | L |
| 35. | Aubrey Huff (13, 35) | 1681 | L |
| 36. | A.J. Pierzynski (15, 35) | 1629 | L |
| 37. | Rafael Furcal (13, 34) | 1605 | B |
| 38. | Vernon Wells (14, 33) | 1601 | R |
| 39. | Alex Gonzalez (14, 35) | 1559 | R |
| 40. | Miguel Cabrera (10, 29) | 1512 | R |
| 41. | Ramon Hernandez (14, 36) | 1509 | R |
| 42. | Mark Teixeira (10, 32) | 1497 | B |
| 43. | Eric Chavez (15, 34) | 1491 | L |
| 44. | Miguel Cairo (17, 38) | 1490 | R |
| 45. | Brandon Inge (12, 35) | 1482 | R |
| 46. | Juan Uribe (12, 32) | 1399 | R |
| 47. | Carl Crawford (11, 30) | 1396 | L |
| 48. | Geoff Blum (14, 39) | 1389 | B |
| 49. | Carlos Pena (12, 34) | 1386 | L |
| 50. | Jack Wilson (12, 34) | 1370 | R |
| Rank | Player (yrs, age) | Games Played | Bats |
| 51. | Jerry Hairston (15, 36) | 1346 | R |
| 52. | Orlando Hudson (11, 34) | 1345 | B |
| 53. | Eric Hinske (11, 34) | 1335 | L |
| 54. | Lyle Overbay (12, 35) | 1324 | L |
| 55. | Ty Wigginton (11, 34) | 1315 | R |
| 56. | Alex Rios (9, 31) | 1299 | R |
| 57. | Matt Holliday (9, 32) | 1293 | R |
| 58. | Jhonny Peralta (10, 30) | 1276 | R |
| 59. | David Wright (9, 29) | 1262 | R |
| 60. | Marco Scutaro (11, 36) | 1259 | R |
| 61. | Brian Roberts (12, 34) | 1250 | B |
| 62. | Cesar Izturis (12, 32) | 1247 | B |
| 63. | Chone Figgins (11, 34) | 1244 | B |
| 64. | Michael Cuddyer (12, 33) | 1240 | R |
| 65. | Mark Ellis (10, 35) | 1236 | R |
| Hideki Matsui (10, 38) | 1236 | L | |
| 67. | Corey Patterson (12, 32) | 1230 | L |
| 68. | Robinson Cano (8, 29) | 1214 | L |
| 69. | Jason Bay (10, 33) | 1210 | R |
| Jose Reyes (10, 29) | 1210 | B | |
| 71. | Nick Swisher (9, 31) | 1209 | B |
| 72. | Jamey Carroll (11, 38) | 1203 | R |
| 73. | Chase Utley (10, 33) | 1192 | L |
| 74. | Brandon Phillips (11, 31) | 1188 | R |
| 75. | Adam LaRoche (9, 32) | 1186 | L |
| 76. | Adrian Gonzalez (9, 30) | 1176 | L |
| 77. | Coco Crisp (11, 32) | 1163 | B |
| 78. | Prince Fielder (8, 28) | 1160 | L |
| 79. | David DeJesus (10, 32) | 1155 | L |
| 80. | Mark DeRosa (15, 37) | 1153 | R |
| 81. | Justin Morneau (10, 31) | 1151 | L |
| 82. | Victor Martinez (10, 33) | 1149 | B |
| 83. | Jeff Francoeur (8, 28) | 1146 | R |
| 84. | Curtis Granderson (9, 31) | 1126 | L |
| 85. | Reed Johnson (10, 35) | 1116 | R |
| 86. | Rod Barajas (14, 36) | 1114 | R |
| 87. | Austin Kearns (11, 32) | 1106 | R |
| 88. | Marlon Byrd (11, 34) | 1103 | R |
| 89. | Travis Hafner (11, 35) | 1101 | L |
| 90. | Ryan Howard (9, 32) | 1098 | L |
| 91. | Omar Infante (11, 30) | 1091 | R |
| Dan Uggla (7, 32) | 1091 | R | |
| 93. | Miguel Olivo (11, 33) | 1083 | R |
| 94. | Yadier Molina (9, 29) | 1082 | R |
| 95. | Scott Podsednik (11, 36) | 1079 | L |
| 96. | Shane Victorino (9, 31) | 1076 | B |
| 97. | Joe Mauer (9, 29) | 1065 | L |
| 98. | Aaron Hill (8, 30) | 1064 | R |
| 99. | Russell Branyan (14, 36) | 1059 | L |
| 100. | Juan Rivera (12, 33) | 1058 | R |