+ - Indicates Hall of Famer. Bold indicates active player.
Statistic Description: Assists
Minimum of 1000 IP, 3000 PA, 500 games (fielding), 200 stolen base attempts (catchers) or 80 stolen base attempts (baserunners only since 1951) or 100 decisions for career and active leaderboards for rate statistics.
| Rank | Player (yrs, age) | Assists as P | Throws |
|---|---|---|---|
| 1. | Andy Pettitte (18, 41) | 525 | L |
| 2. | Mark Buehrle (14, 34) | 524 | L |
| 3. | Derek Lowe (17, 40) | 453 | R |
| 4. | Tim Hudson (15, 37) | 446 | R |
| 5. | Roy Halladay (16, 36) | 389 | R |
| 6. | Jake Westbrook (13, 35) | 360 | R |
| 7. | Jon Garland (13, 33) | 334 | R |
| 8. | Jamey Wright (18, 38) | 329 | R |
| 9. | Ryan Dempster (16, 36) | 320 | R |
| 10. | Barry Zito (14, 35) | 303 | L |
| 11. | Bartolo Colon (16, 40) | 294 | R |
| 12. | Esteban Loaiza (14, 41) | 288 | R |
| 13. | Bronson Arroyo (14, 36) | 286 | R |
| 14. | Aaron Cook (11, 34) | 283 | R |
| 15. | Freddy Garcia (15, 36) | 279 | R |
| 16. | Darren Oliver (20, 42) | 277 | L |
| 17. | CC Sabathia (13, 32) | 275 | L |
| 18. | Miguel Batista (18, 42) | 272 | R |
| 19. | Jason Marquis (14, 34) | 271 | R |
| 20. | A.J. Burnett (15, 36) | 260 | R |
| 21. | Kyle Lohse (13, 34) | 258 | R |
| 22. | Chris Carpenter (15, 38) | 251 | R |
| 23. | Mariano Rivera (19, 43) | 246 | R |
| 24. | Paul Maholm (9, 31) | 242 | L |
| 25. | R.A. Dickey (11, 38) | 232 | R |
| Johan Santana (12, 34) | 232 | L | |
| 27. | Brett Myers (12, 32) | 224 | R |
| 28. | Jake Peavy (12, 32) | 221 | R |
| 29. | Felix Hernandez (9, 27) | 215 | R |
| 30. | Josh Beckett (13, 33) | 213 | R |
| Ted Lilly (15, 37) | 213 | L | |
| 32. | John Lackey (11, 34) | 210 | R |
| 33. | Zach Duke (9, 30) | 201 | L |
| 34. | Aaron Harang (12, 35) | 198 | R |
| Joe Saunders (9, 32) | 198 | L | |
| 36. | Dan Haren (11, 32) | 196 | R |
| 37. | Zack Greinke (10, 29) | 194 | R |
| 38. | Jeff Francis (9, 32) | 193 | L |
| 39. | Chris Capuano (9, 34) | 187 | L |
| 40. | Cole Hamels (8, 29) | 185 | L |