+ - Indicates Hall of Famer. Bold indicates active player.
Statistic Description: Assists
Minimum of 1000 IP, 3000 PA, 500 games (fielding), 200 stolen base attempts (catchers) or 80 stolen base attempts (baserunners only since 1951) or 100 decisions for career and active leaderboards for rate statistics.
| Rank | Player (yrs, age) | Assists as P | Throws |
|---|---|---|---|
| 1. | Jamie Moyer (25, 49) | 644 | L |
| 2. | Livan Hernandez (17, 37) | 601 | R |
| 3. | Mark Buehrle (13, 33) | 515 | L |
| 4. | Andy Pettitte (17, 40) | 513 | L |
| 5. | Derek Lowe (16, 39) | 451 | R |
| 6. | Tim Hudson (14, 36) | 440 | R |
| 7. | Roy Halladay (15, 35) | 383 | R |
| 8. | Jeff Suppan (17, 37) | 358 | R |
| 9. | Jake Westbrook (12, 34) | 353 | R |
| 10. | Jamey Wright (17, 37) | 327 | R |
| 11. | Ryan Dempster (15, 35) | 318 | R |
| 12. | Randy Wolf (14, 35) | 315 | L |
| 13. | Roy Oswalt (12, 34) | 307 | R |
| 14. | Barry Zito (13, 34) | 300 | L |
| 15. | Carlos Zambrano (12, 31) | 290 | R |
| 16. | Bartolo Colon (15, 39) | 289 | R |
| 17. | Kevin Millwood (16, 37) | 284 | R |
| 18. | Aaron Cook (11, 33) | 283 | R |
| 19. | Bronson Arroyo (13, 35) | 278 | R |
| 20. | Freddy Garcia (14, 35) | 277 | R |
| 21. | Miguel Batista (18, 41) | 272 | R |
| Darren Oliver (19, 41) | 272 | L | |
| 23. | CC Sabathia (12, 31) | 266 | L |
| 24. | Jason Marquis (13, 33) | 263 | R |
| 25. | A.J. Burnett (14, 35) | 254 | R |
| Kyle Lohse (12, 33) | 254 | R | |
| 27. | Chris Carpenter (15, 37) | 251 | R |
| 28. | Mariano Rivera (18, 42) | 246 | R |
| 29. | Carl Pavano (14, 36) | 241 | R |
| 30. | Doug Davis (13, 36) | 239 | L |
| 31. | Paul Maholm (8, 30) | 235 | L |
| 32. | Johan Santana (12, 33) | 232 | L |
| 33. | Brad Penny (13, 34) | 226 | R |
| 34. | Joel Pineiro (12, 33) | 225 | R |
| 35. | R.A. Dickey (10, 37) | 223 | R |
| 36. | Brett Myers (11, 31) | 220 | R |
| 37. | Jake Peavy (11, 31) | 216 | R |
| 38. | Ted Lilly (14, 36) | 211 | L |
| 39. | Brett Tomko (14, 39) | 210 | R |
| 40. | Felix Hernandez (8, 26) | 209 | R |