| 2008 | 1 | | 1 | FrRnd | 1 | Rays | Tim Beckham (minors) | | | | | | | | | | | | | HS | Griffin HS (Griffin, GA) |
| 2008 | 1 | | 8 | FrRnd | 8 | White Sox | Gordon Beckham (minors) | 4.8 | 542 | 1865 | 49 | .246 | .693 | | | | | | | 4Yr | University of Georgia (Athens, GA) |
| 2008 | 1 | | 22 | FrRnd | 22 | Mets | Reese Havens (minors) | | | | | | | | | | | | | 4Yr | University of South Carolina (Columbia, SC) |
| 2008 | 1 | | 24 | FrRnd | 24 | Phillies | Anthony Hewitt (minors) | | | | | | | | | | | | | HS | Salisbury Prep (Salisbury, CT) |
| 2008 | 1 | | 30 | FrRnd | 30 | Red Sox | Casey Kelly (minors) | -0.6 | 7 | 10 | 0 | .200 | .400 | 6 | 2 | 3 | 6.21 | 1.69 | 0 | HS | Sarasota HS (Sarasota, FL) |
| 2008 | 1s | | 41 | FrRnd | 41 | Cubs | *Ryan Flaherty (minors) | -0.6 | 107 | 243 | 8 | .185 | .559 | | | | | | | 4Yr | Vanderbilt University (Nashville, TN) |
| 2008 | 2 | | 60 | FrRnd | 14 | Twins | Tyler Ladendorf (minors) | | | | | | | | | | | | | JC | Howard College (Big Spring, TX) |
| 2008 | 2 | | 77 | FrRnd | 31 | Red Sox | Derrik Gibson (minors) | | | | | | | | | | | | | HS | Seaford HS (Seaford, DE) |
| 2008 | 3 | | 79 | FrRnd | 2 | Pirates | Jordy Mercer (minors) | 1.0 | 56 | 108 | 4 | .231 | .705 | | | | | | | 4Yr | Oklahoma State University (Stillwater, OK) |
| 2008 | 3 | | 87 | FrRnd | 10 | Nationals | Danny Espinosa (minors) | 5.5 | 385 | 1411 | 47 | .232 | .703 | | | | | | | 4Yr | California State University Long Beach (Long Beach, CA) |
| 2008 | 3 | | 91 | FrRnd | 14 | Cardinals | Niko Vasquez (minors) | | | | | | | | | | | | | HS | Durango HS (Las Vegas, NV) |
| 2008 | 4 | | 114 | FrRnd | 2 | Pirates | Chase d'Arnaud (minors) | -0.6 | 56 | 149 | 0 | .208 | .507 | | | | | | | 4Yr | Pepperdine University (Malibu, CA) |
| 2008 | 4 | | 117 | FrRnd | 5 | Giants | Brandon Crawford (minors) | 4.1 | 255 | 794 | 12 | .244 | .667 | | | | | | | 4Yr | University of California, Los Angeles (Los Angeles, CA) |
| 2008 | 4 | | 127 | FrRnd | 15 | Dodgers | Dee Gordon (minors) | -0.9 | 159 | 581 | 2 | .251 | .606 | | | | | | | JC | Seminole Community College (Sanford, FL) |
| 2008 | 4 | | 131 | FrRnd | 19 | Cubs | Matt Cerda (minors) | | | | | | | | | | | | | HS | Oceanside HS (Oceanside, CA) |
| 2008 | 4 | | 140 | FrRnd | 28 | Yankees | Corban Joseph (minors) | | | | | | | | | | | | | HS | Franklin HS (Franklin, TN) |
| 2008 | 5 | | 146 | FrRnd | 4 | Orioles | Greg Miclat (minors) | | | | | | | | | | | | | 4Yr | University of Virginia (Charlottesville, VA) |
| 2008 | 5 | | 154 | FrRnd | 12 | Athletics | Jason Christian (minors) | | | | | | | | | | | | | 4Yr | University of Michigan (Ann Arbor, MI) |
| 2008 | 5 | | 159 | FrRnd | 17 | Blue Jays | Tyler Pastornicky (minors) | -1.5 | 82 | 176 | 2 | .239 | .606 | | | | | | | HS | The Pendleton School (Bradenton, FL) |
| 2008 | 6 | | 187 | FrRnd | 15 | Dodgers | Tony Delmonico (minors) | | | | | | | | | | | | | 4Yr | Florida State University (Tallahassee, FL) |
| 2008 | 6 | | 188 | FrRnd | 16 | Brewers | Jose Duran (minors) | | | | | | | | | | | | | 4Yr | Texas A&M University (College Station, TX) |
| 2008 | 6 | | 195 | FrRnd | 23 | Padres | Cole Figueroa (minors) | | | | | | | | | | | | | 4Yr | University of Florida (Gainesville, FL) |
| 2008 | 6 | | 198 | FrRnd | 26 | Diamondbacks | Justin Parker (minors) | | | | | | | | | | | | | 4Yr | Wright State University (Dayton, OH) |
| 2008 | 7 | | 204 | FrRnd | 2 | Pirates | Benji Gonzalez (minors) | | | | | | | | | | | | | HS | Puerto Rico Baseball Academy (Gurabo, PR) |
| 2008 | 8 | | 239 | FrRnd | 7 | Reds | Cody Puckett (minors) | | | | | | | | | | | | | 4Yr | California State University Dominguez Hills (Carson, CA) |
| 2008 | 8 | | 255 | FrRnd | 23 | Padres | Beamer Weems (minors) | | | | | | | | | | | | | 4Yr | Baylor University (Waco, TX) |
| 2008 | 9 | | 265 | FrRnd | 3 | Royals | J.D. Alfaro (minors) | | | | | | | | | | | | | JC | Grayson County College (Denison, TX) |
| 2008 | 11 | | 338 | FrRnd | 16 | Brewers | Michael Marseco (minors) | | | | | | | | | | | | | 4Yr | Samford University (Birmingham, AL) |
| 2008 | 11 | | 343 | FrRnd | 21 | Tigers | Brandon Douglas (minors) | | | | | | | | | | | | | 4Yr | University of Northern Iowa (Cedar Falls, IA) |
| 2008 | 11 | | 349 | FrRnd | 27 | Angels | Rolando Gomez (minors) | | | | | | | | | | | | | HS | Charles Flanagan HS (Pembroke Pines, FL) |
| 2008 | 12 | | 362 | FrRnd | 10 | Astros | Jeff Hulett (minors) | | | | | | | | | | | | | JC | Okaloosa-Walton College (Niceville, FL) |
| 2008 | 12 | | 373 | FrRnd | 21 | Tigers | Brett Anderson (minors) | | | | | | | | | | | | | HS | Bristol Eastern HS (Bristol, CT) |
| 2008 | 13 | | 393 | FrRnd | 11 | Rangers | Ed Koncel (minors) | | | | | | | | | | | | | JC | Joliet Junior College (Joliet, IL) |
| 2008 | 13 | | 400 | FrRnd | 18 | Braves | Travis Adair (minors) | | | | | | | | | | | | | JC | Cleveland State Community College (Cleveland, TN) |
| 2008 | 15 | | 450 | FrRnd | 8 | White Sox | Tyler Kuhn (minors) | | | | | | | | | | | | | 4Yr | West Virginia University (Morgantown, WV) |
| 2008 | 15 | | 454 | FrRnd | 12 | Athletics | Nino Leyja (minors) | | | | | | | | | | | | | HS | Houston Christian HS (Houston, TX) |
| 2008 | 16 | | 476 | FrRnd | 4 | Orioles | Bobby Stevens (minors) | | | | | | | | | | | | | 4Yr | Northern Illinois University (DeKalb, IL) |
| 2008 | 16 | | 496 | FrRnd | 24 | Phillies | Troy Hanzawa (minors) | | | | | | | | | | | | | 4Yr | San Diego State University (San Diego, CA) |
| 2008 | 17 | | 508 | FrRnd | 6 | Marlins | Richard Soignier (minors) | | | | | | | | | | | | | 4Yr | University of Louisiana at Monroe (Monroe, LA) |
| 2008 | 17 | | 511 | FrRnd | 9 | Nationals | Jose Lozada (minors) | | | | | | | | | | | | | 4Yr | Bethune-Cookman College (Daytona Beach, FL) |
| 2008 | 17 | | 525 | FrRnd | 23 | Padres | Derek Shunk (minors) | | | | | | | | | | | | | 4Yr | Villanova University (Villanova, PA) |
| 2008 | 17 | | 530 | FrRnd | 28 | Yankees | Addison Maruszak (minors) | | | | | | | | | | | | | 4Yr | University of South Florida (Tampa, FL) |
| 2008 | 18 | | 534 | FrRnd | 2 | Pirates | Jarek Cunningham (minors) | | | | | | | | | | | | | HS | Mount Spokane HS (Mead, WA) |
| 2008 | 18 | | 537 | FrRnd | 5 | Giants | Brooks Lindsley (minors) | | | | | | | | | | | | | JC | Lower Columbia College (Longview, WA) |
| 2008 | 18 | | 559 | FrRnd | 27 | Angels | Adam Younger (minors) | | | | | | | | | | | | | 4Yr | Oral Roberts University (Tulsa, OK) |
| 2008 | 19 | | 571 | FrRnd | 9 | Nationals | Steve Lombardozzi (minors) | -0.1 | 176 | 506 | 3 | .259 | .632 | | | | | | | JC | St. Petersburg College (St. Petersburg, FL) |
| 2008 | 19 | | 573 | FrRnd | 11 | Rangers | Harold Martinez (minors) | | | | | | | | | | | | | HS | Braddock HS (Miami, FL) |
| 2008 | 20 | | 603 | FrRnd | 11 | Rangers | Michael Hollander (minors) | | | | | | | | | | | | | 4Yr | Louisiana State University (Baton Rouge, LA) |
| 2008 | 20 | | 605 | FrRnd | 13 | Cardinals | Luis Mateo (minors) | | | | | | | | | | | | | HS | Jose Rojas Cortez School (Orocovis, PR) |
| 2008 | 20 | | 610 | FrRnd | 18 | Braves | Robert Brooks (minors) | | | | | | | | | | | | | JC | Wallace State Community College (Hanceville) (Hanceville, AL) |
| 2008 | 20 | | 612 | FrRnd | 20 | Mariners | Fred Bello (minors) | | | | | | | | | | | | | JC | Cerro Coso CC (Ridgecrest, CA) |
| 2008 | 21 | | 640 | FrRnd | 18 | Braves | Tyler Barnett (minors) | | | | | | | | | | | | | 4Yr | Eastern Kentucky University (Richmond, KY) |
| 2008 | 21 | | 641 | FrRnd | 19 | Cubs | Logan Watkins (minors) | | | | | | | | | | | | | HS | Goddard HS (Goddard, KS) |
| 2008 | 21 | | 643 | FrRnd | 21 | Tigers | Adam Frost (minors) | | | | | | | | | | | | | 4Yr | St. Norbert College (De Pere, WI) |
| 2008 | 22 | | 665 | FrRnd | 13 | Cardinals | Colt Sedbrook (minors) | | | | | | | | | | | | | 4Yr | University of Arizona (Tucson, AZ) |
| 2008 | 22 | | 673 | FrRnd | 21 | Tigers | Zach MacPhee (minors) | | | | | | | | | | | | | HS | O'Connor HS (Phoenix, AZ) |
| 2008 | 23 | | 710 | FrRnd | 28 | Yankees | Ryan Wilkes (minors) | | | | | | | | | | | | | 4Yr | University of Kentucky (Lexington, KY) |
| 2008 | 24 | | 730 | FrRnd | 18 | Braves | Shayne Moody (minors) | | | | | | | | | | | | | 4Yr | University of North Carolina at Charlotte (Charlotte, NC) |
| 2008 | 24 | | 737 | FrRnd | 25 | Rockies | Thomas Field (minors) | 0.2 | 21 | 50 | 0 | .260 | .575 | | | | | | | 4Yr | Texas State University (San Marcos, TX) |
| 2008 | 24 | | 741 | FrRnd | 29 | Indians | Kevin Fontanez (minors) | | | | | | | | | | | | | HS | Puerto Rico Baseball Academy (Gurabo, PR) |
| 2008 | 25 | | 758 | FrRnd | 16 | Brewers | John Delaney (minors) | | | | | | | | | | | | | 4Yr | Quinnipiac College (Hamden, CT) |
| 2008 | 25 | | 767 | FrRnd | 25 | Rockies | Andy Burns (minors) | | | | | | | | | | | | | HS | Rocky Mountain HS (Fort Collins, CO) |
| 2008 | 26 | | 793 | FrRnd | 21 | Tigers | Brent Wyatt (minors) | | | | | | | | | | | | | 4Yr | Lewis-Clark State College (Lewiston, ID) |
| 2008 | 26 | | 795 | FrRnd | 23 | Padres | Dean Anna (minors) | | | | | | | | | | | | | 4Yr | Ball State University (Muncie, IN) |
| 2008 | 27 | | 803 | FrRnd | 1 | Rays | Luis Marchena (minors) | | | | | | | | | | | | | HS | Otay Ranch HS (Chula Vista, CA) |
| 2008 | 27 | | 818 | FrRnd | 16 | Brewers | Austin Adams (minors) | | | | | | | | | | | | | JC | Faulkner State College (Bay Minette, AL) |
| 2008 | 27 | | 819 | FrRnd | 17 | Blue Jays | Bryan Kervin (minors) | | | | | | | | | | | | | 4Yr | Texas Christian University (Fort Worth, TX) |
| 2008 | 27 | | 820 | FrRnd | 18 | Braves | Anthony Rendon (minors) | 0.1 | 8 | 25 | 0 | .240 | .647 | | | | | | | HS | Lamar HS (Houston, TX) |
| 2008 | 27 | | 830 | FrRnd | 28 | Yankees | Garrison Lassiter (minors) | | | | | | | | | | | | | HS | West Forsyth HS (Clemmons, NC) |
| 2008 | 28 | | 841 | FrRnd | 9 | Nationals | Nick Arata (minors) | | | | | | | | | | | | | 4Yr | Florida Atlantic University (Boca Raton, FL) |
| 2008 | 28 | | 844 | FrRnd | 12 | Athletics | Dusty Coleman (minors) | | | | | | | | | | | | | 4Yr | Wichita State University (Wichita, KS) |
| 2008 | 28 | | 852 | FrRnd | 20 | Mariners | Scott Savastano (minors) | | | | | | | | | | | | | 4Yr | Franklin Pierce University (Rindge, NH) |
| 2008 | 28 | | 858 | FrRnd | 26 | Diamondbacks | Adam Smith (minors) | | | | | | | | | | | | | HS | Klein HS (Klein, TX) |
| 2008 | 29 | | 872 | FrRnd | 10 | Astros | Christopher Jackson (minors) | | | | | | | | | | | | | 4Yr | Virginia Commonwealth University (Richmond, VA) |
| 2008 | 29 | | 888 | FrRnd | 26 | Diamondbacks | Travis Meiners (minors) | | | | | | | | | | | | | JC | Des Moines Area Community College (Boone, IA) |
| 2008 | 30 | | 897 | FrRnd | 5 | Giants | Vladimir Frias (minors) | | | | | | | | | | | | | 4Yr | Tennessee Wesleyan College (Athens, TN) |
| 2008 | 30 | | 916 | FrRnd | 24 | Phillies | D.J. Henderson (minors) | | | | | | | | | | | | | HS | Southeastern HS (Detroit, MI) |
| 2008 | 31 | | 933 | FrRnd | 11 | Rangers | Kyle Higgins (minors) | | | | | | | | | | | | | 4Yr | Monmouth University (West Long Branch, NJ) |
| 2008 | 31 | | 940 | FrRnd | 18 | Braves | Jason Stolz (minors) | | | | | | | | | | | | | HS | Kell HS (Marietta, GA) |
| 2008 | 32 | | 956 | FrRnd | 4 | Orioles | Brandon Loy (minors) | | | | | | | | | | | | | HS | Rowlett HS (Rowlett, TX) |
| 2008 | 32 | | 962 | FrRnd | 10 | Astros | B.A. Vollmuth (minors) | | | | | | | | | | | | | HS | Biloxi HS (Biloxi, MS) |
| 2008 | 34 | | 1020 | FrRnd | 8 | White Sox | Marcus Semien (minors) | | | | | | | | | | | | | HS | St. Mary's HS (Berkeley, CA) |
| 2008 | 34 | | 1038 | FrRnd | 26 | Diamondbacks | Jake Elmore (minors) | -0.5 | 33 | 79 | 0 | .215 | .540 | | | | | | | 4Yr | Arizona State University (Tempe, AZ) |
| 2008 | 35 | | 1072 | FrRnd | 30 | Red Sox | Carson Blair (minors) | | | | | | | | | | | | | HS | Liberty Christian School (Argyle, TX) |
| 2008 | 36 | | 1084 | FrRnd | 12 | Athletics | Jon Berti (minors) | | | | | | | | | | | | | HS | Troy HS (Troy, MI) |
| 2008 | 37 | | 1116 | FrRnd | 14 | Twins | Javier Brown (minors) | | | | | | | | | | | | | JC | Grossmont College (El Cajon, CA) |
| 2008 | 37 | | 1132 | FrRnd | 30 | Red Sox | Thomas Di Benedetto (minors) | | | | | | | | | | | | | 4Yr | Trinity College (Hartford, CT) |
| 2008 | 39 | | 1171 | FrRnd | 9 | Nationals | James Keithley (minors) | | | | | | | | | | | | | 4Yr | University of Texas at San Antonio (San Antonio, TX) |
| 2008 | 39 | | 1173 | FrRnd | 11 | Rangers | Brad Miller (minors) | | | | | | | | | | | | | HS | Olympia HS (Orlando, FL) |
| 2008 | 40 | | 1196 | FrRnd | 4 | Orioles | Kirk Singer (minors) | | | | | | | | | | | | | HS | Los Alamitos HS (Los Alamitos, CA) |
| 2008 | 40 | | 1198 | FrRnd | 6 | Marlins | Trent Fuller (minors) | | | | | | | | | | | | | HS | Fairfield HS (Fairfield, CA) |
| 2008 | 40 | | 1211 | FrRnd | 19 | Cubs | Jared McDonald (minors) | | | | | | | | | | | | | JC | Pima Community College (Tucson, AZ) |
| 2008 | 40 | | 1220 | FrRnd | 28 | Yankees | Sam Mende (minors) | | | | | | | | | | | | | HS | Clearwater Central Catholic HS (Clearwater, FL) |
| 2008 | 41 | | 1238 | FrRnd | 16 | Brewers | Joseph Scott (minors) | | | | | | | | | | | | | 4Yr | California State University Fullerton (Fullerton, CA) |
| 2008 | 41 | | 1240 | FrRnd | 18 | Braves | Ian Gilley (minors) | | | | | | | | | | | | | HS | Northside HS (Fort Smith, AR) |
| 2008 | 41 | | 1241 | FrRnd | 19 | Cubs | Jordan Petraitis (minors) | | | | | | | | | | | | | 4Yr | Miami University of Ohio (Oxford, OH) |
| 2008 | 41 | | 1247 | FrRnd | 25 | Rockies | Dean Espy (minors) | | | | | | | | | | | | | HS | Red Mountain HS (Mesa, AZ) |
| 2008 | 42 | | 1268 | FrRnd | 16 | Brewers | Ryan Wood (minors) | | | | | | | | | | | | | 4Yr | East Carolina University (Greenville, NC) |
| 2008 | 42 | | 1281 | FrRnd | 29 | Indians | Logan Thompson (minors) | | | | | | | | | | | | | HS | Jupiter HS (Jupiter, FL) |
| 2008 | 43 | | 1303 | FrRnd | 21 | Tigers | Tyler Grimes (minors) | | | | | | | | | | | | | HS | North HS (Wichita, KS) |
| 2008 | 44 | | 1337 | FrRnd | 25 | Diamondbacks | David Cooper (minors) | | | | | | | | | | | | | 4Yr | Mount Olive College (Mount Olive, NC) |
| 2008 | 45 | | 1349 | FrRnd | 8 | White Sox | Julian Kenner (minors) | | | | | | | | | | | | | HS | Whitney-Young HS (Chicago, IL) |
| 2008 | 45 | | 1350 | FrRnd | 9 | Nationals | Colin Rooney (minors) | | | | | | | | | | | | | JC | Saddleback College (Mission Viejo, CA) |
| 2008 | 45 | | 1367 | FrRnd | 26 | Yankees | Creede Simpson (minors) | | | | | | | | | | | | | HS | Auburn HS (Auburn, AL) |
| 2008 | 46 | | 1371 | FrRnd | 2 | Pirates | Scott McGough (minors) | | | | | | | | | | | | | HS | Plum HS (Pittsburgh, PA) |
| 2008 | 46 | | 1374 | FrRnd | 5 | Giants | Joseph Hainsfurther (minors) | | | | | | | | | | | | | HS | Highland Park HS (Dallas, TX) |
| 2008 | 46 | | 1377 | FrRnd | 8 | White Sox | Lee Fischer (minors) | | | | | | | | | | | | | 4Yr | University of Missouri Columbia (Columbia, MO) |
| 2008 | 46 | | 1380 | FrRnd | 11 | Rangers | Erik Morrison (minors) | | | | | | | | | | | | | 4Yr | University of Kansas (Lawrence, KS) |
| 2008 | 46 | | 1384 | FrRnd | 15 | Brewers | Carlos George (minors) | | | | | | | | | | | | | HS | James Monroe HS (Bronx, NY) |
| 2008 | 46 | | 1385 | FrRnd | 16 | Braves | Matt Harrison (minors) | | | | | | | | | | | | | HS | Green Valley HS (Henderson, NV) |
| 2008 | 47 | | 1419 | FrRnd | 23 | Diamondbacks | Drew Maggi (minors) | | | | | | | | | | | | | HS | Brophy College Preparatory (Phoenix, AZ) |
| 2008 | 47 | | 1422 | FrRnd | 26 | Indians | Randon Henika (minors) | | | | | | | | | | | | | HS | Garber HS (Essexville, MI) |
| 2008 | 48 | | 1426 | FrRnd | 3 | Royals | Terrence Buchanan (minors) | | | | | | | | | | | | | HS | Mount Carmel HS (San Diego, CA) |
| 2008 | 48 | | 1429 | FrRnd | 6 | Marlins | Barrett Serrato (minors) | | | | | | | | | | | | | HS | Community HS (West Chicago, IL) |
| 2008 | 48 | | 1444 | FrRnd | 21 | Phillies | Mark Ginther (minors) | | | | | | | | | | | | | HS | Jenks HS (Tulsa, OK) |
| 2008 | 48 | | 1445 | FrRnd | 22 | Rockies | Austin Nola (minors) | | | | | | | | | | | | | HS | Catholic HS (Baton Rouge, LA) |
| 2008 | 50 | | 1485 | FrRnd | 8 | White Sox | Steven Florence (minors) | | | | | | | | | | | | | HS | Simeon HS (Chicago, IL) |