| 2010 | 1 | | 5 | FrRnd | 5 | Indians | Drew Pomeranz (minors) | 1.6 | 26 | 31 | 1 | .226 | .637 | 26 | 4 | 10 | 5.01 | 1.45 | 0 | 4Yr | University of Mississippi (Oxford, MS) |
| 2010 | 1 | | 13 | FrRnd | 13 | White Sox | Chris Sale (minors) | 12.2 | 118 | 2 | 0 | .000 | .000 | 118 | 26 | 13 | 2.83 | 1.09 | 12 | 4Yr | Florida Gulf Coast University (Fort Myers, FL) |
| 2010 | 1 | | 27 | FrRnd | 27 | Phillies | Jesse Biddle (minors) | | | | | | | | | | | | | HS | Germantown Friends HS (Philadelphia, PA) |
| 2010 | 2 | | 51 | FrRnd | 1 | Nationals | Sammy Solis (minors) | | | | | | | | | | | | | 4Yr | University of San Diego (San Diego, CA) |
| 2010 | 2 | | 61 | FrRnd | 11 | Blue Jays | Griffin Murphy (minors) | | | | | | | | | | | | | HS | Redlands East Valley HS (Redlands, CA) |
| 2010 | 2 | | 68 | FrRnd | 18 | Tigers | Drew Smyly (minors) | 2.5 | 39 | 1 | 0 | .000 | .000 | 39 | 6 | 3 | 3.65 | 1.22 | 1 | 4Yr | University of Arkansas (Fayetteville, AR) |
| 2010 | 2 | | 73 | FrRnd | 23 | Marlins | Rob Rasmussen (minors) | | | | | | | | | | | | | 4Yr | University of California, Los Angeles (Los Angeles, CA) |
| 2010 | 2 | | 80 | FrRnd | 30 | Blue Jays via Red Sox | *Justin Nicolino (minors) | | | | | | | | | | | | | HS | University HS (Orlando, FL) |
| 2010 | 3 | | 102 | FrRnd | 20 | Twins | Patrick Dean (minors) | | | | | | | | | | | | | 4Yr | Boston College (Chestnut Hill, MA) |
| 2010 | 4 | | 119 | FrRnd | 4 | Royals | Kevin Chapman (minors) | | | | | | | | | | | | | 4Yr | University of Florida (Gainesville, FL) |
| 2010 | 4 | | 130 | FrRnd | 15 | Cubs | Hunter Ackerman (minors) | | | | | | | | | | | | | JC | Louisburg College (Louisburg, NC) |
| 2010 | 4 | | 132 | FrRnd | 17 | Mariners | James Paxton (minors) | | | | | | | | | | | | | | |
| 2010 | 4 | | 141 | FrRnd | 26 | Phillies | Bryan Morgado (minors) | | | | | | | | | | | | | 4Yr | University of Tennessee (Knoxville, TN) |
| 2010 | 4 | | 144 | FrRnd | 29 | Angels | Max Russell (minors) | | | | | | | | | | | | | 4Yr | Florida Southern College (Lakeland, FL) |
| 2010 | 5 | | 151 | FrRnd | 6 | Diamondbacks | Cody Wheeler (minors) | | | | | | | | | | | | | 4Yr | Coastal Carolina University (Conway, SC) |
| 2010 | 5 | | 163 | FrRnd | 18 | Tigers | Alex Burgos (minors) | | | | | | | | | | | | | JC | Manatee-Sarasota CC (Sarasota, FL) |
| 2010 | 6 | | 179 | FrRnd | 4 | Royals | Scott Alexander (minors) | | | | | | | | | | | | | 4Yr | Sonoma State University (Rohnert Park, CA) |
| 2010 | 6 | | 186 | FrRnd | 11 | Blue Jays | Sean Nolin (minors) | | | | | | | | | | | | | JC | San Jacinto College North (Houston, TX) |
| 2010 | 6 | | 195 | FrRnd | 20 | Twins | Logan Darnell (minors) | | | | | | | | | | | | | 4Yr | University of Kentucky (Lexington, KY) |
| 2010 | 6 | | 198 | FrRnd | 23 | Giants | Michael Kickham (minors) | | | | | | | | | | | | | 4Yr | Missouri State University (Springfield, MO) |
| 2010 | 6 | | 199 | FrRnd | 24 | Cardinals | John Gast (minors) | | | | | | | | | | | | | 4Yr | Florida State University (Tallahassee, FL) |
| 2010 | 7 | | 208 | FrRnd | 3 | Orioles | Matt Bywater (minors) | | | | | | | | | | | | | 4Yr | Pepperdine University (Malibu, CA) |
| 2010 | 7 | | 216 | FrRnd | 11 | Blue Jays | Mitchell Taylor (minors) | | | | | | | | | | | | | HS | Spring HS (Spring, TX) |
| 2010 | 7 | | 226 | FrRnd | 21 | Rangers | Jimmy Reyes (minors) | | | | | | | | | | | | | 4Yr | Elon University (Elon, NC) |
| 2010 | 7 | | 230 | FrRnd | 25 | Rockies | Kraig Sitton (minors) | | | | | | | | | | | | | 4Yr | Oregon State University (Corvallis, OR) |
| 2010 | 7 | | 232 | FrRnd | 27 | Dodgers | Ryan Christenson (minors) | | | | | | | | | | | | | JC | South Mountain Community College (Phoenix, AZ) |
| 2010 | 7 | | 233 | FrRnd | 28 | Red Sox | Chris Hernandez (minors) | | | | | | | | | | | | | 4Yr | University of Miami (Coral Gables, FL) |
| 2010 | 7 | | 234 | FrRnd | 29 | Angels | Josh Osich (minors) | | | | | | | | | | | | | 4Yr | Oregon State University (Corvallis, OR) |
| 2010 | 8 | | 236 | FrRnd | 1 | Nationals | Matt Grace (minors) | | | | | | | | | | | | | 4Yr | University of California, Los Angeles (Los Angeles, CA) |
| 2010 | 8 | | 246 | FrRnd | 11 | Blue Jays | Logan Ehlers (minors) | | | | | | | | | | | | | HS | Nebraska City HS (Nebraska City, NE) |
| 2010 | 8 | | 250 | FrRnd | 15 | Cubs | Cameron Greathouse (minors) | | | | | | | | | | | | | JC | Gulf Coast Community College (Panama City, FL) |
| 2010 | 8 | | 259 | FrRnd | 24 | Cardinals | Daniel Bibona (minors) | | | | | | | | | | | | | 4Yr | University of California, Irvine (Irvine, CA) |
| 2010 | 9 | | 273 | FrRnd | 8 | Astros | Thomas Shirley (minors) | | | | | | | | | | | | | 4Yr | Xavier University (Cincinnati, OH) |
| 2010 | 9 | | 274 | FrRnd | 9 | Padres | Josh Spence (minors) | 0.4 | 51 | 0 | 0 | | | 51 | 0 | 3 | 3.15 | 1.28 | 0 | 4Yr | Arizona State University (Tempe, AZ) |
| 2010 | 9 | | 277 | FrRnd | 12 | Reds | Tanner Robles (minors) | | | | | | | | | | | | | 4Yr | Oregon State University (Corvallis, OR) |
| 2010 | 9 | | 289 | FrRnd | 24 | Cardinals | Tyler Lyons (minors) | | | | | | | | | | | | | 4Yr | Oklahoma State University (Stillwater, OK) |
| 2010 | 10 | | 303 | FrRnd | 8 | Astros | Evan Grills (minors) | | | | | | | | | | | | | HS | Sinclair SS (Whitby, ON) |
| 2010 | 10 | | 313 | FrRnd | 17 | Tigers | Cole Nelson (minors) | | | | | | | | | | | | | 4Yr | Auburn University (Auburn, AL) |
| 2010 | 10 | | 321 | FrRnd | 25 | Phillies | Mario Hollands (minors) | | | | | | | | | | | | | 4Yr | University of California, Santa Barbara (Santa Barbara, CA) |
| 2010 | 10 | | 324 | FrRnd | 28 | Angels | Aaron Meade (minors) | | | | | | | | | | | | | 4Yr | Missouri State University (Springfield, MO) |
| 2010 | 11 | | 332 | FrRnd | 8 | Mets | Adam Kolarek (minors) | | | | | | | | | | | | | 4Yr | University of Maryland (College Park, MD) |
| 2010 | 11 | | 340 | FrRnd | 16 | Cubs | Eric Jokisch (minors) | | | | | | | | | | | | | 4Yr | Northwestern University (Evanston, IL) |
| 2010 | 11 | | 344 | FrRnd | 20 | Braves | Chasen Shreve (minors) | | | | | | | | | | | | | JC | College of Southern Nevada (Henderson, NV) |
| 2010 | 11 | | 346 | FrRnd | 22 | Rangers | Chris Hanna (minors) | | | | | | | | | | | | | HS | Stratford HS (Goose Creek, SC) |
| 2010 | 11 | | 347 | FrRnd | 23 | Marlins | Grant Dayton (minors) | | | | | | | | | | | | | 4Yr | Auburn University (Auburn, AL) |
| 2010 | 11 | | 349 | FrRnd | 25 | Cardinals | Ben Freeman (minors) | | | | | | | | | | | | | HS | Lake Gibson HS (Lakeland, FL) |
| 2010 | 12 | | 356 | FrRnd | 1 | Nationals | Robbie Ray (minors) | | | | | | | | | | | | | HS | Brentwood HS (Brentwood, TN) |
| 2010 | 12 | | 373 | FrRnd | 18 | Tigers | Kyle Ryan (minors) | | | | | | | | | | | | | HS | Auburndale HS (Auburndale, FL) |
| 2010 | 12 | | 380 | FrRnd | 25 | Rockies | Matthew Crocker (minors) | | | | | | | | | | | | | 4Yr | University of Texas at San Antonio (San Antonio, TX) |
| 2010 | 13 | | 387 | FrRnd | 2 | Pirates | Christopher Kirsch (minors) | | | | | | | | | | | | | HS | Marple Newtown HS (Newtown Square, PA) |
| 2010 | 13 | | 391 | FrRnd | 6 | Diamondbacks | Kevin Ziomek (minors) | | | | | | | | | | | | | HS | Amherst Regional HS (Amherst, MA) |
| 2010 | 13 | | 394 | FrRnd | 9 | Padres | Miguel Pena (minors) | | | | | | | | | | | | | JC | San Jacinto College North (Houston, TX) |
| 2010 | 13 | | 396 | FrRnd | 11 | Blue Jays | Tyler Painton (minors) | | | | | | | | | | | | | HS | Centennial HS (Bakersfield, CA) |
| 2010 | 13 | | 402 | FrRnd | 17 | Mariners | Jason Markovitz (minors) | | | | | | | | | | | | | 4Yr | California State University Long Beach (Long Beach, CA) |
| 2010 | 13 | | 405 | FrRnd | 20 | Twins | Ryan O'Rourke (minors) | | | | | | | | | | | | | 4Yr | Merrimack College (North Andover, MA) |
| 2010 | 14 | | 432 | FrRnd | 17 | Mariners | Tyler Linehan (minors) | | | | | | | | | | | | | HS | Sheldon HS (Sacramento, CA) |
| 2010 | 14 | | 442 | FrRnd | 27 | Dodgers | Alex McRee (minors) | | | | | | | | | | | | | 4Yr | University of Georgia (Athens, GA) |
| 2010 | 15 | | 450 | FrRnd | 5 | Indians | Benjamin Holmes (minors) | | | | | | | | | | | | | HS | Clackamas HS (Clackamas, OR) |
| 2010 | 15 | | 456 | FrRnd | 11 | Blue Jays | Zak Adams (minors) | | | | | | | | | | | | | HS | Flower Mound HS (Flower Mound, TX) |
| 2010 | 15 | | 457 | FrRnd | 12 | Reds | Stephen Hunt (minors) | | | | | | | | | | | | | 4Yr | University of South Florida (Tampa, FL) |
| 2010 | 15 | | 459 | FrRnd | 14 | Brewers | Christopher Bates (minors) | | | | | | | | | | | | | HS | Regis HS (New York, NY) |
| 2010 | 15 | | 461 | FrRnd | 16 | Rays | Brandon Henderson (minors) | | | | | | | | | | | | | HS | Chesnee HS (Chesnee, SC) |
| 2010 | 15 | | 468 | FrRnd | 23 | Giants | Andrew Barbosa (minors) | | | | | | | | | | | | | 4Yr | University of South Florida (Tampa, FL) |
| 2010 | 15 | | 472 | FrRnd | 27 | Dodgers | Jake Eliopoulos (minors) | | | | | | | | | | | | | JC | Chipola College (Marianna, FL) |
| 2010 | 15 | | 474 | FrRnd | 29 | Angels | Carmine Giardina (minors) | | | | | | | | | | | | | 4Yr | University of Tampa (Tampa, FL) |
| 2010 | 16 | | 485 | FrRnd | 10 | Athletics | Ryan Hughes (minors) | | | | | | | | | | | | | 4Yr | University of Nebraska at Lincoln (Lincoln, NE) |
| 2010 | 16 | | 492 | FrRnd | 17 | Mariners | Jordan Shipers (minors) | | | | | | | | | | | | | HS | South Harrison HS (Bethany, MO) |
| 2010 | 16 | | 495 | FrRnd | 20 | Twins | Clint Dempster (minors) | | | | | | | | | | | | | 4Yr | Nicholls State University (Thibodaux, LA) |
| 2010 | 16 | | 502 | FrRnd | 27 | Dodgers | Andrew Pevsner (minors) | | | | | | | | | | | | | 4Yr | Johns Hopkins University (Baltimore, MD) |
| 2010 | 16 | | 505 | FrRnd | 30 | Yankees | Evan Rutckyj (minors) | | | | | | | | | | | | | HS | St. Joseph's Catholic HS (St. Thomas, ON) |
| 2010 | 17 | | 519 | FrRnd | 14 | Brewers | Brian Garman (minors) | | | | | | | | | | | | | 4Yr | University of Cincinnati (Cincinnati, OH) |
| 2010 | 18 | | 549 | FrRnd | 14 | Brewers | Thomas Keeling (minors) | | | | | | | | | | | | | 4Yr | Oklahoma State University (Stillwater, OK) |
| 2010 | 18 | | 551 | FrRnd | 16 | Rays | Jim Patterson (minors) | | | | | | | | | | | | | 4Yr | Arizona State University (Tempe, AZ) |
| 2010 | 19 | | 567 | FrRnd | 2 | Pirates | Kent Emanuel (minors) | | | | | | | | | | | | | HS | Woodstock HS (Woodstock, GA) |
| 2010 | 19 | | 585 | FrRnd | 20 | Twins | Matthew Arguello (minors) | | | | | | | | | | | | | HS | Davidson HS (Mobile, AL) |
| 2010 | 20 | | 598 | FrRnd | 3 | Orioles | Matt Drummond (minors) | | | | | | | | | | | | | 4Yr | University of California, Los Angeles (Los Angeles, CA) |
| 2010 | 20 | | 606 | FrRnd | 11 | Blue Jays | Art Charles (minors) | | | | | | | | | | | | | JC | Bakersfield College (Bakersfield, CA) |
| 2010 | 20 | | 611 | FrRnd | 16 | Rays | C.J. Riefenhauser (minors) | | | | | | | | | | | | | JC | Chipola College (Marianna, FL) |
| 2010 | 20 | | 616 | FrRnd | 21 | Rangers | Sam Wilson (minors) | | | | | | | | | | | | | HS | Eldorado HS (Albuquerque, NM) |
| 2010 | 21 | | 635 | FrRnd | 10 | Athletics | Michael Anarumo (minors) | | | | | | | | | | | | | 4Yr | LeMoyne College (Syracuse, NY) |
| 2010 | 21 | | 641 | FrRnd | 16 | Rays | Adam Liberatore (minors) | | | | | | | | | | | | | 4Yr | Tennessee Technological University (Cookeville, TN) |
| 2010 | 21 | | 647 | FrRnd | 22 | Marlins | Kenneth Toves (minors) | | | | | | | | | | | | | 4Yr | University of New Mexico (Albuquerque, NM) |
| 2010 | 22 | | 665 | FrRnd | 10 | Athletics | Michael Strong (minors) | | | | | | | | | | | | | 4Yr | Oklahoma State University (Stillwater, OK) |
| 2010 | 22 | | 685 | FrRnd | 30 | Yankees | Trevor Johnson (minors) | | | | | | | | | | | | | JC | College of the Desert (Palm Desert, CA) |
| 2010 | 23 | | 689 | FrRnd | 4 | Royals | Steven Neff (minors) | | | | | | | | | | | | | 4Yr | University of South Carolina (Columbia, SC) |
| 2010 | 23 | | 691 | FrRnd | 6 | Diamondbacks | Roberto Padilla (minors) | | | | | | | | | | | | | JC | Ohlone College (Fremont, CA) |
| 2010 | 23 | | 713 | FrRnd | 28 | Red Sox | Austin Wright (minors) | | | | | | | | | | | | | JC | Chipola College (Marianna, FL) |
| 2010 | 24 | | 723 | FrRnd | 8 | Astros | Adam Champion (minors) | | | | | | | | | | | | | 4Yr | University of Arkansas at Little Rock (Little Rock, AR) |
| 2010 | 24 | | 732 | FrRnd | 17 | Mariners | Bennett Whitmore (minors) | | | | | | | | | | | | | 4Yr | Concordia University (Irvine, CA) |
| 2010 | 25 | | 746 | FrRnd | 1 | Nationals | Christian Meza (minors) | | | | | | | | | | | | | JC | Santa Ana College (Santa Ana, CA) |
| 2010 | 25 | | 751 | FrRnd | 6 | Diamondbacks | Matt Talley (minors) | | | | | | | | | | | | | 4Yr | The Citadel (Charleston, SC) |
| 2010 | 25 | | 754 | FrRnd | 9 | Padres | Josue Montanez (minors) | | | | | | | | | | | | | HS | Ramon Vila Mayo HS (San Juan, PR) |
| 2010 | 25 | | 761 | FrRnd | 16 | Rays | Matthew Spann (minors) | | | | | | | | | | | | | HS | Central HS (Columbia, TN) |
| 2010 | 25 | | 763 | FrRnd | 18 | Tigers | Shawn Teufel (minors) | | | | | | | | | | | | | 4Yr | Liberty University (Lynchburg, VA) |
| 2010 | 25 | | 770 | FrRnd | 25 | Rockies | Kenneth Roberts (minors) | | | | | | | | | | | | | 4Yr | Middle Tennessee State University (Murfreesboro, TN) |
| 2010 | 26 | | 776 | FrRnd | 1 | Nationals | Chris Manno (minors) | | | | | | | | | | | | | 4Yr | Duke University (Durham, NC) |
| 2010 | 26 | | 783 | FrRnd | 8 | Astros | Alex Sogard (minors) | | | | | | | | | | | | | 4Yr | North Carolina State University (Raleigh, NC) |
| 2010 | 26 | | 785 | FrRnd | 10 | Athletics | Jake Brown (minors) | | | | | | | | | | | | | 4Yr | Georgia Southern University (Statesboro, GA) |
| 2010 | 26 | | 786 | FrRnd | 11 | Blue Jays | Jay Johnson (minors) | | | | | | | | | | | | | 4Yr | Texas Tech University (Lubbock, TX) |
| 2010 | 26 | | 787 | FrRnd | 12 | Reds | Ty Stuckey (minors) | | | | | | | | | | | | | 4Yr | University of Houston (Houston, TX) |
| 2010 | 26 | | 788 | FrRnd | 13 | White Sox | Kevin Rath (minors) | | | | | | | | | | | | | 4Yr | California State University Fullerton (Fullerton, CA) |
| 2010 | 26 | | 789 | FrRnd | 14 | Brewers | Daniel Gibson (minors) | | | | | | | | | | | | | HS | Jesuit HS (Tampa, FL) |
| 2010 | 26 | | 791 | FrRnd | 16 | Rays | Justin Woodall (minors) | | | | | | | | | | | | | 4Yr | University of Alabama (Tuscaloosa, AL) |
| 2010 | 26 | | 803 | FrRnd | 28 | Red Sox | Dillon Overton (minors) | | | | | | | | | | | | | HS | Weatherford HS (Weatherford, OK) |
| 2010 | 26 | | 804 | FrRnd | 29 | Angels | Dakota Robinson (minors) | | | | | | | | | | | | | 4Yr | Centenary College of Louisiana (Shreveport, LA) |
| 2010 | 27 | | 817 | FrRnd | 12 | Reds | Joel Bender (minors) | | | | | | | | | | | | | HS | Oak Hills HS (Cincinnati, OH) |
| 2010 | 27 | | 818 | FrRnd | 13 | White Sox | Pete Gehle (minors) | | | | | | | | | | | | | 4Yr | Azusa Pacific University (Azusa, CA) |
| 2010 | 27 | | 820 | FrRnd | 15 | Cubs | Bryan Harper (minors) | | | | | | | | | | | | | JC | College of Southern Nevada (Henderson, NV) |
| 2010 | 27 | | 826 | FrRnd | 21 | Rangers | Alexander Claudio (minors) | | | | | | | | | | | | | HS | Isabel Flores HS (Juncos, PR) |
| 2010 | 27 | | 830 | FrRnd | 25 | Rockies | Blake Keitzman (minors) | | | | | | | | | | | | | 4Yr | Western Oregon University (Monmouth, OR) |
| 2010 | 28 | | 841 | FrRnd | 6 | Diamondbacks | Keith Hessler (minors) | | | | | | | | | | | | | 4Yr | Coastal Carolina University (Conway, SC) |
| 2010 | 28 | | 842 | FrRnd | 7 | Mets | Jeremy Gould (minors) | | | | | | | | | | | | | 4Yr | Duke University (Durham, NC) |
| 2010 | 28 | | 848 | FrRnd | 13 | White Sox | Tom Windle (minors) | | | | | | | | | | | | | HS | Osseo HS (Osseo, MN) |
| 2010 | 28 | | 849 | FrRnd | 14 | Brewers | Dane Amedee (minors) | | | | | | | | | | | | | JC | Louisiana State University, Eunice (Eunice, LA) |
| 2010 | 28 | | 853 | FrRnd | 18 | Tigers | Jack Duffey (minors) | | | | | | | | | | | | | HS | The Heritage School (Newnan, GA) |
| 2010 | 28 | | 858 | FrRnd | 23 | Giants | Gaspar Santiago (minors) | | | | | | | | | | | | | JC | Ranger College (Ranger, TX) |
| 2010 | 29 | | 868 | FrRnd | 3 | Orioles | Cameron Roth (minors) | | | | | | | | | | | | | 4Yr | University of North Carolina at Wilmington (Wilmington, NC) |
| 2010 | 29 | | 870 | FrRnd | 5 | Indians | Kirby Bellow (minors) | | | | | | | | | | | | | HS | Nederland HS (Nederland, TX) |
| 2010 | 29 | | 872 | FrRnd | 7 | Mets | Hamilton Bennett (minors) | | | | | | | | | | | | | 4Yr | Tennessee Wesleyan College (Athens, TN) |
| 2010 | 29 | | 880 | FrRnd | 15 | Cubs | Casey Harman (minors) | | | | | | | | | | | | | 4Yr | Clemson University (Clemson, SC) |
| 2010 | 29 | | 883 | FrRnd | 18 | Tigers | Chris Joyce (minors) | | | | | | | | | | | | | JC | Central Arizona College (Coolidge, AZ) |
| 2010 | 29 | | 890 | FrRnd | 25 | Rockies | Marco Gonzales (minors) | | | | | | | | | | | | | HS | Rocky Mountain HS (Fort Collins, CO) |
| 2010 | 30 | | 902 | FrRnd | 7 | Mets | Josh Edgin (minors) | -0.5 | 45 | 0 | 0 | | | 45 | 1 | 3 | 5.91 | 1.31 | 0 | 4Yr | Francis Marion University (Florence, SC) |
| 2010 | 30 | | 904 | FrRnd | 9 | Padres | Donald Snelten (minors) | | | | | | | | | | | | | HS | Lakes Community HS (Antioch, IL) |
| 2010 | 30 | | 905 | FrRnd | 10 | Athletics | Jeff Urlaub (minors) | | | | | | | | | | | | | 4Yr | Grand Canyon University (Phoenix, AZ) |
| 2010 | 30 | | 908 | FrRnd | 13 | White Sox | Kylin Turnbull (minors) | | | | | | | | | | | | | JC | Santa Barbara City College (Santa Barbara, CA) |
| 2010 | 30 | | 913 | FrRnd | 18 | Tigers | Logan Hoch (minors) | | | | | | | | | | | | | 4Yr | Wichita State University (Wichita, KS) |
| 2010 | 30 | | 917 | FrRnd | 22 | Marlins | Zach Robertson (minors) | | | | | | | | | | | | | 4Yr | University of Iowa (Iowa City, IA) |
| 2010 | 30 | | 918 | FrRnd | 23 | Giants | Ryan Bradley (minors) | | | | | | | | | | | | | 4Yr | Southern Illinois University Carbondale (Carbondale, IL) |
| 2010 | 30 | | 919 | FrRnd | 24 | Cardinals | Iden Nazario (minors) | | | | | | | | | | | | | 4Yr | University of Miami (Coral Gables, FL) |
| 2010 | 30 | | 921 | FrRnd | 26 | Phillies | Nicholas Gonzalez (minors) | | | | | | | | | | | | | HS | A. P. Leto HS (Tampa, FL) |
| 2010 | 31 | | 933 | FrRnd | 8 | Astros | Travis Blankenship (minors) | | | | | | | | | | | | | 4Yr | University of Kansas (Lawrence, KS) |
| 2010 | 31 | | 938 | FrRnd | 13 | White Sox | Robert Young (minors) | | | | | | | | | | | | | 4Yr | Dartmouth College (Hanover, NH) |
| 2010 | 31 | | 946 | FrRnd | 21 | Rangers | Justin Earls (minors) | | | | | | | | | | | | | 4Yr | University of Georgia (Athens, GA) |
| 2010 | 32 | | 968 | FrRnd | 13 | White Sox | Jarrett Casey (minors) | | | | | | | | | | | | | 4Yr | Northern Kentucky University (Highland Heights, KY) |
| 2010 | 32 | | 970 | FrRnd | 15 | Cubs | Brent Ebinger (minors) | | | | | | | | | | | | | 4Yr | Lambuth University (Jackson, TN) |
| 2010 | 32 | | 979 | FrRnd | 24 | Cardinals | Ryan Copeland (minors) | | | | | | | | | | | | | 4Yr | Illinois State University (Normal, IL) |
| 2010 | 32 | | 985 | FrRnd | 30 | Yankees | Kramer Sneed (minors) | | | | | | | | | | | | | 4Yr | Barton College (Wilson, NC) |
| 2010 | 33 | | 986 | FrRnd | 1 | Nationals | Ryan Sherriff (minors) | | | | | | | | | | | | | JC | West Los Angeles College (Culver City, CA) |
| 2010 | 33 | | 987 | FrRnd | 2 | Pirates | Justin Ennis (minors) | | | | | | | | | | | | | 4Yr | Louisiana State University in Shreveport (Shreveport, LA) |
| 2010 | 33 | | 999 | FrRnd | 14 | Brewers | William Kankel (minors) | | | | | | | | | | | | | 4Yr | University of Houston (Houston, TX) |
| 2010 | 33 | | 1004 | FrRnd | 19 | Braves | Albert Minnis (minors) | | | | | | | | | | | | | HS | Lawrence HS (Lawrence, KS) |
| 2010 | 33 | | 1005 | FrRnd | 20 | Twins | Justin Parker (minors) | | | | | | | | | | | | | JC | Cosumnes River College (Sacramento, CA) |
| 2010 | 33 | | 1006 | FrRnd | 21 | Rangers | Matt Hill (minors) | | | | | | | | | | | | | JC | Georgia Perimeter College (Covington, GA) |
| 2010 | 33 | | 1008 | FrRnd | 23 | Giants | James Birmingham (minors) | | | | | | | | | | | | | 4Yr | Coastal Carolina University (Conway, SC) |
| 2010 | 33 | | 1012 | FrRnd | 27 | Dodgers | Brett Lee (minors) | | | | | | | | | | | | | JC | Bishop State JC (Mobile, AL) |
| 2010 | 34 | | 1020 | FrRnd | 5 | Indians | Kyle Petter (minors) | | | | | | | | | | | | | JC | El Camino College (Torrance, CA) |
| 2010 | 34 | | 1032 | FrRnd | 17 | Mariners | Tyler Whitney (minors) | | | | | | | | | | | | | 4Yr | Mississippi State University (Mississippi State, MS) |
| 2010 | 34 | | 1034 | FrRnd | 19 | Braves | Matt Fouch (minors) | | | | | | | | | | | | | 4Yr | United States Military Academy (West Point, NY) |
| 2010 | 34 | | 1037 | FrRnd | 22 | Marlins | Steven Dennison (minors) | | | | | | | | | | | | | 4Yr | Wheaton College (Wheaton, IL) |
| 2010 | 36 | | 1079 | FrRnd | 4 | Royals | Mitchell Beacom (minors) | | | | | | | | | | | | | 4Yr | University of California, Los Angeles (Los Angeles, CA) |
| 2010 | 36 | | 1088 | FrRnd | 13 | White Sox | Benjamin Griset (minors) | | | | | | | | | | | | | HS | Gustine HS (Gustine, CA) |
| 2010 | 36 | | 1091 | FrRnd | 16 | Rays | Robert Dickmann (minors) | | | | | | | | | | | | | 4Yr | Pepperdine University (Malibu, CA) |
| 2010 | 36 | | 1099 | FrRnd | 24 | Cardinals | Dean Kiekhefer (minors) | | | | | | | | | | | | | 4Yr | University of Louisville (Louisville, KY) |
| 2010 | 36 | | 1101 | FrRnd | 26 | Phillies | Neal Davis (minors) | | | | | | | | | | | | | 4Yr | University of Virginia (Charlottesville, VA) |
| 2010 | 37 | | 1106 | FrRnd | 1 | Nationals | Nick Serino (minors) | | | | | | | | | | | | | 4Yr | University of Massachusetts Amherst (Amherst, MA) |
| 2010 | 37 | | 1118 | FrRnd | 13 | White Sox | Christopher Lee (minors) | | | | | | | | | | | | | HS | T. R. Robinson HS (Tampa, FL) |
| 2010 | 37 | | 1122 | FrRnd | 17 | Mariners | Ryan Kiel (minors) | | | | | | | | | | | | | 4Yr | Marshall University (Huntington, WV) |
| 2010 | 37 | | 1135 | FrRnd | 30 | Yankees | Cam Hobson (minors) | | | | | | | | | | | | | 4Yr | University of Dayton (Dayton, OH) |
| 2010 | 38 | | 1136 | FrRnd | 1 | Nationals | Nicholas Lee (minors) | | | | | | | | | | | | | JC | Weatherford College (Weatherford, TX) |
| 2010 | 38 | | 1144 | FrRnd | 9 | Padres | Noah Mull (minors) | | | | | | | | | | | | | 4Yr | Wheeling Jesuit University (Wheeling, WV) |
| 2010 | 38 | | 1147 | FrRnd | 12 | Reds | Matt Leonard (minors) | | | | | | | | | | | | | 4Yr | California Polytechnic State University, San Luis Obispo (San Luis Obispo, CA) |
| 2010 | 38 | | 1153 | FrRnd | 18 | Tigers | Jake Dziubczynski (minors) | | | | | | | | | | | | | JC | Central Arizona College (Coolidge, AZ) |
| 2010 | 38 | | 1157 | FrRnd | 22 | Marlins | Forrest Moore (minors) | | | | | | | | | | | | | 4Yr | Mississippi State University (Mississippi State, MS) |
| 2010 | 38 | | 1159 | FrRnd | 24 | Cardinals | Jeff Nadeau (minors) | | | | | | | | | | | | | 4Yr | Louisiana State University in Shreveport (Shreveport, LA) |
| 2010 | 39 | | 1178 | FrRnd | 13 | White Sox | Levi Schlick (minors) | | | | | | | | | | | | | JC | Barton County Community College (Great Bend, KS) |
| 2010 | 39 | | 1184 | FrRnd | 19 | Braves | Stephen Foster (minors) | | | | | | | | | | | | | 4Yr | Lewis-Clark State College (Lewiston, ID) |
| 2010 | 39 | | 1185 | FrRnd | 20 | Twins | Bart Carter (minors) | | | | | | | | | | | | | 4Yr | Western Kentucky University (Bowling Green, KY) |
| 2010 | 40 | | 1203 | FrRnd | 8 | Astros | Jeremiah Meiners (minors) | | | | | | | | | | | | | 4Yr | Francis Marion University (Florence, SC) |
| 2010 | 40 | | 1210 | FrRnd | 15 | Cubs | Brian Smith (minors) | | | | | | | | | | | | | HS | St. Mary Catholic SS (Pickering, ON) |
| 2010 | 40 | | 1212 | FrRnd | 17 | Mariners | Nate Reed (minors) | | | | | | | | | | | | | 4Yr | Kutztown University of Pennsylvania (Kutztown, PA) |
| 2010 | 40 | | 1221 | FrRnd | 26 | Phillies | Jeffrey Harvill (minors) | | | | | | | | | | | | | HS | Evangel Christian HS (Shreveport, LA) |
| 2010 | 41 | | 1241 | FrRnd | 16 | Rays | Chris Rearick (minors) | | | | | | | | | | | | | 4Yr | North Georgia College and State University (Dahlonega, GA) |
| 2010 | 41 | | 1245 | FrRnd | 20 | Twins | Sam Spangler (minors) | | | | | | | | | | | | | 4Yr | University of Hawaii at Manoa (Honolulu, HI) |
| 2010 | 42 | | 1257 | FrRnd | 2 | Pirates | Stephen Lumpkins (minors) | | | | | | | | | | | | | 4Yr | American University (Washington, DC) |
| 2010 | 42 | | 1258 | FrRnd | 3 | Orioles | Jake Pettit (minors) | | | | | | | | | | | | | 4Yr | Western Oregon University (Monmouth, OR) |
| 2010 | 42 | | 1265 | FrRnd | 10 | Athletics | Louie Lechich (minors) | | | | | | | | | | | | | HS | St. Mary's HS (Stockton, CA) |
| 2010 | 42 | | 1267 | FrRnd | 12 | Reds | Mitchell Hopkins (minors) | | | | | | | | | | | | | JC | Louisiana State University, Eunice (Eunice, LA) |
| 2010 | 42 | | 1275 | FrRnd | 20 | Twins | Brett Carroll (minors) | | | | | | | | | | | | | 4Yr | William Paterson University (Wayne, NJ) |
| 2010 | 42 | | 1276 | FrRnd | 21 | Rangers | Kevin Johnson (minors) | | | | | | | | | | | | | 4Yr | University of Cincinnati (Cincinnati, OH) |
| 2010 | 43 | | 1286 | FrRnd | 1 | Nationals | Corey Littrell (minors) | | | | | | | | | | | | | HS | Trinity HS (Louisville, KY) |
| 2010 | 43 | | 1289 | FrRnd | 4 | Royals | Dillon Wilson (minors) | | | | | | | | | | | | | JC | Western Oklahoma State JC (Altus, OK) |
| 2010 | 43 | | 1294 | FrRnd | 9 | Padres | Mark Hardy (minors) | | | | | | | | | | | | | 4Yr | University of British Columbia (Vancouver, BC) |
| 2010 | 43 | | 1296 | FrRnd | 11 | Blue Jays | Ron Schreurs (minors) | | | | | | | | | | | | | HS | Freedom HS (Orlando, FL) |
| 2010 | 43 | | 1299 | FrRnd | 14 | Brewers | Steven Okert (minors) | | | | | | | | | | | | | JC | Grayson County College (Denison, TX) |
| 2010 | 43 | | 1307 | FrRnd | 22 | Marlins | Matt Tracy (minors) | | | | | | | | | | | | | 4Yr | University of Mississippi (Oxford, MS) |
| 2010 | 43 | | 1311 | FrRnd | 26 | Phillies | James Hodgskin (minors) | | | | | | | | | | | | | HS | Bishop Moore HS (Orlando, FL) |
| 2010 | 43 | | 1315 | FrRnd | 30 | Yankees | Kyle Hunter (minors) | | | | | | | | | | | | | 4Yr | Kansas State University (Manhattan, KS) |
| 2010 | 44 | | 1320 | FrRnd | 5 | Indians | Brock Stassi (minors) | | | | | | | | | | | | | 4Yr | University of Nevada-Reno (Reno, NV) |
| 2010 | 44 | | 1322 | FrRnd | 7 | Mets | Kevin Gelinas (minors) | | | | | | | | | | | | | 4Yr | University of California, Santa Barbara (Santa Barbara, CA) |
| 2010 | 44 | | 1327 | FrRnd | 12 | Reds | Ed Campbell (minors) | | | | | | | | | | | | | HS | Bridgewater-Raynham HS (Bridgewater, MA) |
| 2010 | 44 | | 1335 | FrRnd | 20 | Twins | David Deminsky (minors) | | | | | | | | | | | | | 4Yr | St.Cloud State University (St. Cloud, MN) |
| 2010 | 44 | | 1337 | FrRnd | 22 | Marlins | Tyler Abbott (minors) | | | | | | | | | | | | | HS | Royal HS (Simi Valley, CA) |
| 2010 | 44 | | 1340 | FrRnd | 25 | Rockies | Kyle Richter (minors) | | | | | | | | | | | | | HS | Santa Margarita Catholic HS (Rancho Santa Margarita, CA) |
| 2010 | 44 | | 1345 | FrRnd | 30 | Yankees | David Middendorf (minors) | | | | | | | | | | | | | 4Yr | Northern Kentucky University (Highland Heights, KY) |
| 2010 | 45 | | 1352 | FrRnd | 7 | Mets | Terrence Jackson (minors) | | | | | | | | | | | | | 4Yr | Oklahoma City University (Oklahoma City, OK) |
| 2010 | 45 | | 1354 | FrRnd | 9 | Padres | Michael Fagan (minors) | | | | | | | | | | | | | HS | San Diego Jewish Academy (San Diego, CA) |
| 2010 | 45 | | 1361 | FrRnd | 16 | Rays | Blake Freeman (minors) | | | | | | | | | | | | | HS | Sunnyslope HS (Phoenix, AZ) |
| 2010 | 45 | | 1365 | FrRnd | 20 | Twins | James Buckelew (minors) | | | | | | | | | | | | | HS | Collins Hills HS (Suwanee, GA) |
| 2010 | 45 | | 1371 | FrRnd | 26 | Phillies | Michael Francisco (minors) | | | | | | | | | | | | | 4Yr | Villanova University (Villanova, PA) |
| 2010 | 46 | | 1382 | FrRnd | 7 | Mets | Mike Jefferson (minors) | | | | | | | | | | | | | 4Yr | Louisiana Tech University (Ruston, LA) |
| 2010 | 46 | | 1383 | FrRnd | 8 | Astros | Lawrence Pardo (minors) | | | | | | | | | | | | | HS | Christopher Columbus HS (Miami, FL) |
| 2010 | 46 | | 1388 | FrRnd | 13 | White Sox | Ronzelle Fort (minors) | | | | | | | | | | | | | HS | Harlan HS (Chicago, IL) |
| 2010 | 46 | | 1392 | FrRnd | 17 | Mariners | David Rollins (minors) | | | | | | | | | | | | | JC | San Jacinto College North (Houston, TX) |
| 2010 | 46 | | 1400 | FrRnd | 25 | Rockies | Mitch Horacek (minors) | | | | | | | | | | | | | HS | Thunder Ridge HS (Littleton, CO) |
| 2010 | 46 | | 1404 | FrRnd | 29 | Angels | Darren Fischer (minors) | | | | | | | | | | | | | HS | Cumberland Regional HS (Bridgeton, NJ) |
| 2010 | 47 | | 1429 | FrRnd | 24 | Cardinals | Justin Wright (minors) | | | | | | | | | | | | | 4Yr | Virginia Polytechnic Institute and State University (Blacksburg, VA) |
| 2010 | 47 | | 1431 | FrRnd | 26 | Phillies | Ethan Stewart (minors) | | | | | | | | | | | | | JC | New Mexico Junior College (Hobbs, NM) |
| 2010 | 47 | | 1433 | FrRnd | 28 | Red Sox | David Roseboom (minors) | | | | | | | | | | | | | HS | LaSalle Institute (Troy, NY) |
| 2010 | 47 | | 1435 | FrRnd | 30 | Yankees | Fred Lewis (minors) | | | | | | | | | | | | | 4Yr | Tennessee Wesleyan College (Athens, TN) |
| 2010 | 48 | | 1437 | FrRnd | 2 | Pirates | Dillon Haviland (minors) | | | | | | | | | | | | | HS | South Fayette HS (McDonald, PA) |
| 2010 | 48 | | 1440 | FrRnd | 5 | Indians | C.T. Bradford (minors) | | | | | | | | | | | | | HS | Pace HS (Pace, FL) |
| 2010 | 48 | | 1449 | FrRnd | 14 | Brewers | Marques Kyles (minors) | | | | | | | | | | | | | 4Yr | Limestone College (Gaffney, SC) |
| 2010 | 48 | | 1457 | FrRnd | 22 | Marlins | Beau Wright (minors) | | | | | | | | | | | | | JC | Orange Coast College (Costa Mesa, CA) |
| 2010 | 48 | | 1461 | FrRnd | 26 | Phillies | Kyle Ottoson (minors) | | | | | | | | | | | | | JC | South Mountain Community College (Phoenix, AZ) |
| 2010 | 49 | | 1474 | FrRnd | 9 | Padres | Elliot Glynn (minors) | | | | | | | | | | | | | 4Yr | University of Connecticut (Storrs, CT) |
| 2010 | 49 | | 1489 | FrRnd | 24 | Cardinals | Bob Revesz (minors) | | | | | | | | | | | | | 4Yr | University of Louisville (Louisville, KY) |
| 2010 | 49 | | 1491 | FrRnd | 26 | Phillies | Kyle Hallock (minors) | | | | | | | | | | | | | 4Yr | Kent State University (Kent, OH) |
| 2010 | 49 | | 1494 | FrRnd | 29 | Angels | Alexander Burkard (minors) | | | | | | | | | | | | | 4Yr | Georgia College and State University (Milledgeville, GA) |
| 2010 | 50 | | 1496 | FrRnd | 1 | Nationals | Harris Fanaroff (minors) | | | | | | | | | | | | | HS | Winston Churchill HS (Potomac, MD) |
| 2010 | 50 | | 1513 | FrRnd | 18 | Tigers | Jake Ross (minors) | | | | | | | | | | | | | JC | Wor-Wic CC (Salisbury, MD) |
| 2010 | 50 | | 1524 | FrRnd | 29 | Angels | John Wiedenbauer (minors) | | | | | | | | | | | | | 4Yr | University of Tampa (Tampa, FL) |