Óscar Eduardo Villarreal
- Bats Left, Throws Right
- Height 6' 0", Weight 177 lb.
- Debut March 31, 2003
- Final Game July 1, 2008
- Born November 22, 1981 in San Nicolás de los Garza, Nuevo León Mexico
No-one knows if this makes Óscar Villarreal unique, but he struck out a batter with the very first pitch of his career. It came when he replaced the injured Bret Prinz with a 1-2 count on opposite pitcher Hideo Nomo. It was the only pitch that Villarreal threw that day.
Villarreal allowed one run in five innings in five games for the Mexican national team in the 2008 Americas Baseball Cup, being used as a set-up man for Rafael Diaz. He helped Mexico advance to the 2009 Baseball World Cup.