Mesa Solar Sox
- Location: Mesa, AZ
- League: Arizona Fall League (2009-)
- Stadium: Hohokam Park (1997-2013), Sloan Park (2014-)
The Mesa Solar Sox are an Arizona Fall League team which played their home games at HoHokam Park in Mesa, AZ, the Cactus League Spring Training Facility of the Chicago Cubs. The Solar Sox play in the East Division of the AFL.