Neptunus Rotterdam was the Hoofdklasse powerhouse of the early 21st Century. They won a record seven consecutive titles from 1999 through 2005 before several stars departed prior to the 2006 season, including 2005 MVP Dirk van 't Klooster and 2005 Pitcher of the Year Rob Cordemans. Neptunus is sponsored by DOOR Training and located in Rotterdam. They play their home games in DOOR Neptunus Familiestadion.
Previously known as Levi's Neptunus Rotterdam, Kok Juwelier Neptunus Rotterdam, KOK Neptunus Rotterdam, Tropicana Neptunus, Tropicana Neptunus Rotterdam and for many years DOOR Neptunus before being sponsored by the government of Curaçao, the club also won Hoofdklasse titles in 1981, 1991, 1993 and 1995. They also won the European Cup five consecutive seasons from 2000 through 2004 as well as in 1994, 1996 and 2015.
When Neptunus won the 2009 Holland Series, they tied Haarlem Nicols for the most titles (12) in league history. They became the first 13-time titlist when they won the 2010 Holland Series. After two years without a title, they won the 2013 Holland Series. They were the first Hoofdklasse team to 1,000 wins (on April 27, 2014), doing so after only 1,387 games; at least four other teams had more games played but Kinheim was second in wins at a distant 816 at that point. They also won the 2014 Holland Series, 2015 Holland Series and 2016 Holland Series.
- 1981: Wim Onderstal
- 1991, 1993-1994: Charles Urbanus Jr.
- 1995-1998: Jan Collins
- 1998-2001: Robert Eenhoorn
- 2007-2008: Eric de Bruin
- 2009-2010: Steve Janssen
- 2011-2012: Jan Collins
- 2013-2016: Evert-Jan 't Hoen
- 2017- : Ronald Jaarsma