The DSL Astros have represented the Houston Astros in the Dominican Summer League. The Astros also sent players to the 1989 DSL White Sox/Astros/Rangers, 1990 DSL Astros/Cardinals, 1994-1995 DSL Astros/Brewers, and 1996 DSL Astros/Red Sox. The Astros sent players to a second team in 1993, the DSL Giants/Phillies/Astros. In 2014 the DSL Astros were replaced by two teams, the DSL Astros Blue and the DSL Astros Orange
The team has produced Johan Santana, Melvin Mora, Alejandro Freire, Santiago Ramirez, Wandy Rodriguez and Jailen Peguero.