| Pick | Team | Player | Position | School (Type) | Hometown | Notes
|
| 1 | Pittsburgh Pirates | Gerrit Cole | P | UCLA (Col.) | Orange, CA |
|
| 2 | Seattle Mariners | Danny Hultzen | P | University of Virginia (Col.) | Bethesda, MD |
|
| 3 | Arizona Diamondbacks | Trevor Bauer | P | UCLA (Col.) | Valencia, CA |
|
| 4 | Baltimore Orioles | Dylan Bundy | P | Owasso High School (HS) | Owasso, OK |
|
| 5 | Kansas City Royals | Bubba Starling | OF | Gardner-Edgerton High School (HS) | Gardner, KS |
|
| 6 | Washington Nationals | Anthony Rendon | 3B | Rice University (Col.) | Houston, TX |
|
| 7 | Arizona Diamondbacks | Archie Bradley | P | Broken Arrow High School (HS) | Broken Arrow, OK | Compensation for failure to sign 2010 Pick Barret Loux
|
| 8 | Cleveland Indians | Francisco Lindor | SS | Montverde Academy (HS) | Clermont, FL |
|
| 9 | Chicago Cubs | Javier Baez | SS | Arlington Country Day School (HS) | Jacksonville, FL |
|
| 10 | San Diego Padres | Cory Spangenberg | 2B | Indian River State College (Col.) | Clarks Summit, PA | Compensation for failure to sign 2010 Pick Karsten Whitson
|
| 11 | Houston Astros | George Springer | OF | University of Connecticut (Col.) | New Britain, CT |
|
| 12 | Milwaukee Brewers | Taylor Jungmann | P | University of Texas (Col.) | Temple, TX |
|
| 13 | New York Mets | Brandon Nimmo | OF | Cheyenne East High School (HS) | Cheyenne, WY | Highest pick to date for a player from Wyoming
|
| 14 | Florida Marlins | Jose Fernandez | P | Braulio Alonso High School (HS) | Tampa, FL |
|
| 15 | Milwaukee Brewers | Jed Bradley | P | Georgia Tech (Col.) | Huntsville, AL | Compensation for failure to sign 2010 Pick Dylan Covey
|
| 16 | Los Angeles Dodgers | Chris Reed | P | Stanford University (Col.) | Reseda, CA |
|
| 17 | Los Angeles Angels | Chris Cron, Jr. | 1B | University of Utah (Col.) | Phoenix, AZ |
|
| 18 | Oakland Athletics | Sonny Gray | P | Vanderbilt University (Col.) | Smyrna, TN |
|
| 19 | Boston Red Sox | Matt Barnes | P | University of Connecticut (Col.) | Bethel, CT | Compensation from Detroit Tigers for Victor Martinez
|
| 20 | Colorado Rockies | Tyler Anderson | P | University of Oregon (Col.) | Las Vegas, NV |
|
| 21 | Toronto Blue Jays | Tyler Beede | P | Lawrence Academy at Groton (HS) | Auburn, MA | Did Not Sign
|
| 22 | St. Louis Cardinals | Kolten Wong | 2B | University of Hawaii (Col.) | Hilo, HI |
|
| 23 | Washington Nationals | Alex Meyer | P | University of Kentucky (Col.) | Greensburg, IN | Compensation from Chicago White Sox for Adam Dunn
|
| 24 | Tampa Bay Rays | Taylor Guerrieri | P | Spring Valley High School (HS) | Columbia, SC | Compensation from Boston Red Sox for Carl Crawford
|
| 25 | San Diego Padres | Joe Ross | P | Bishop O'Dowd High School (HS) | Oakland, CA |
|
| 26 | Boston Red Sox | Blake Swihart | C | V. Sue Cleveland High School (HS) | Rio Rancho, NM | Compensation from Texas Rangers for Adrian Beltre
|
| 27 | Cincinnati Reds | Robert Stephenson | P | Alhambra High School (HS) | Martinez, CA |
|
| 28 | Atlanta Braves | Sean Gilmartin | P | Florida State University (Col.) | Moorpark, CA |
|
| 29 | San Francisco Giants | Joe Panik | SS | St. John's University (Col.) | Hopewell Junction, NY |
|
| 30 | Minnesota Twins | Levi Michael | SS | University of North Carolina (Col.) | Welcome, NC |
|
| 31 | Tampa Bay Rays | Mikie Mahtook | OF | Louisiana State University (Col.) | Lafayette, LA | Compensation from New York Yankees for Rafael Soriano
|
| 32 | Tampa Bay Rays | Jake Hager | SS | Sierra Vista High School (HS) | Las Vegas, NV |
|
| 33 | Texas Rangers | Kevin Matthews | P | Richmond Hill High School (HS) | Richmond Hill, GA | Compensation from Philadelphia Phillies for Cliff Lee
|
| Pick | Team | Player | Position | School (Type) | Hometown | Notes
|
| 34 | Washington Nationals | Brian Goodwin | OF | Miami Dade College (Col.) | Rocky Mount, NC | Compensation for Adam Dunn
|
| 35 | Toronto Blue Jays | Jacob Anderson | OF | Chino High School (HS) | Chino, CA | Compensation for Scott Downs
|
| 36 | Boston Red Sox | Henry Owens | P | Edison High School (HS) | Huntington Beach, CA | Compensation for Victor Martinez
|
| 37 | Texas Rangers | Zach Cone | OF | University of Georgia (Col.) | Stone Mountain, GA | Compensation for Cliff Lee
|
| 38 | Tampa Bay Rays | Brandon Martin | SS | Santiago High School (HS) | Corona, CA | Compensation for Rafael Soriano
|
| 39 | Philadelphia Phillies | Larry Greene | OF | Berrien County High School | Nashville, GA | Compensation for Jayson Werth
|
| 40 | Boston Red Sox | Jackie Bradley Jr. | OF | University of South Carolina | Prince George, VA | Compensation for Adrian Beltre
|
| 41 | Tampa Bay Rays | Tyler Goeddel | 3B | St. Francis High School | Hillsborough, CA | Compensation for Carl Crawford
|
| 42 | Tampa Bay Rays | Jeff Ames | P | Lower Columbia College | Vancouver, WA | Compensation for Grant Balfour
|
| 43 | Arizona Diamondbacks | Andrew Chafin | P | Kent State University | Wakeman, OH | Compensation for Adam LaRoche
|
| 44 | New York Mets | Michael Fullmer | P | Deer Creek High School | Edmond, OK | Compensation for Pedro Feliciano
|
| 45 | Colorado Rockies | Trevor Story | SS | Irving High School | Irving, TX | Compensation for Octavio Dotel
|
| 46 | Toronto Blue Jays | Joe Musgrove | P | Grossmont High School | El Cajon, CA | Compensation for John Buck
|
| 47 | Chicago White Sox | Keenyn Walker | OF | Central Arizona College | Salt Lake City, UT | Compensation for J.J. Putz
|
| 48 | San Diego Padres | Michael Kelly | P | West Boca Raton High School | Boynton Beach, FL | Compensation for Jon Garland
|
| 49 | San Francisco Giants | Kyle Crick | P | Sherman High School | Sherman, TX | Compensation for Juan Uribe
|
| 50 | Minnesota Twins | Travis Harrison | 3B | Tustin High School | Aliso Viejo, CA | Compensation for Orlando Hudson
|
| 51 | New York Yankees | Dante Bichette, Jr. | 3B | Orangewood Christian High School | Orlando, FL | Compensation for Javier Vazquez
|
| 52 | Tampa Bay Rays | Blake Snell | P | Shorewood High School | Shoreline, WA | Compensation for Brad Hawpe
|
| 53 | Toronto Blue Jays | Dwight Smith, Jr. | OF | McIntosh High School | Peachtree City, GA | Compensation for Kevin Gregg
|
| 54 | San Diego Padres | Brett Austin | C | Providence High School | Charlotte, NC | Compensation for Yorvit Torrealba/Did Not Sign
|
| 55 | Minnesota Twins | Hudson Boyd | P | Bishop Verot High School | Ft. Myers, FL | Compensation for Jesse Crain
|
| 56 | Tampa Bay Rays | Kes Carter | OF | Western Kentucky University | Brentwood, TN | Compensation for Joaquin Benoit
|
| 57 | Toronto Blue Jays | Kevin Comer | P | Seneca High School | Shamong Township, NJ | Compensation for Miguel Olivo
|
| 58 | San Diego Padres | Jace Peterson | SS | McNeese State University | Lake Charles, LA | Compensation for Kevin Correia
|
| 59 | Tampa Bay Rays | Grayson Garvin | P | Vanderbilt University | Suwanee, GA | Compensation for Randy Choate
|
| 60 | Tampa Bay Rays | James Harris | OF | Oakland Technical High School | Oakland, CA | Compensation for Chad Qualls
|
