The Tigers and Cardinals entered the 2006 season on vastly different planes. The Cardinals were the epitome of "so close, yet so far", appearing in the playoffs numerous times in recent seasons, but never quite finishing the job. The Tigers were never uttered in the same sentence as the World Series, the organization was still only three seasons removed from losing 119 games. When the air cooled and October settled in, these two historic franchises went toe to toe. The Cardinals won in five games, ending the Tigers magical run.
The AL bracket included a strong Yankees club that pounded its way to 97 wins, the always feisty Twins, and Billy Beane's Athletics. The Dodgers and Mets reached the NL playoffs, joining the Padres who reached the postseason for a second consecutive season. The Cardinals made waste of the Padres and took out the Mets in seven games.
 Series Summaries
 American League
 ALDS: Detroit Tigers vs. New York Yankees
 ALDS: Oakland Athletics vs. Minnesota Twins
 ALCS: Detroit Tigers vs. Oakland Athletics
 National League
 NLDS: New York Mets vs. Los Angeles Dodgers
 NLDS: St. Louis Cardinals vs. San Diego Padres
 NLCS: St. Louis Cardinals vs. New York Mets
 World Series: St. Louis Cardinals vs. Detroit Tigers
 NL Team Stats
 AL Team Stats